Protein Alignment ATP13A2 and CG6230

DIOPT Version :10

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: NP_609490.1
• Gene: CG6230 / 34546
• FlyBaseID: FBgn0027582
• Length: 1225
• Species: Drosophila melanogaster
• Alignment Length: 1165
• Identity: 309/1165 - (26%)
• Similarity: 512/1165 - (43%)
• Gaps: 250/1165 - (21%)

Human    45 WRVIGY-HVVVWMMAGIPLLLFRWKPLWGVR----LRLRPCNLAHAETLVIEIRDKEDSSWQLFT 104
            |..:|: .|:......|..|||.:   |.|.    |..|...|..|..|               .
  Fly   103 WNDVGFIGVLAIAFLHILTLLFCY---WSVHVLAFLTCRRVKLPGANVL---------------A 149

Human   105 VQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQRVLRYYLFQG 169
            ..|.|...|...:.|...|:.|||.:|                               .|::||.
  Fly   150 KVVPTPNNGNSKIVPIRSSKLEDGSTQ-------------------------------YYFVFQK 183

Human   170 QRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKA-IYGPNVISIPVKSYPQLLVD 233
            .:|:|.|.::.|..|....:|..  ..:.|..||..::.:.|.. .||.|.:.:.|..:.:|.::
  Fly   184 TKYVWNEDRKTFRAVEFPVNGLL--STYSSSRGLETEEDIKRATQTYGNNEMEMVVPEFHELFIE 246

Human   234 EALNPYYGFQAFSIALWLADHYYWYAL-CIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVC 297
            .|..|::.||.||:.||..|.|::|:| .:|::.:....:    .::|.:.:.::.|:..:..:.
  Fly   247 RATAPFFVFQVFSVGLWCMDDYWYYSLFTLFMLIAFECTI----VKQQLRNMSEIRKMGNKPYLI 307

Human   298 RPGGEEEW--VDSSELVPGDCLVL--PQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTAL-- 356
            ....:.:|  :.|.||:|||.:.:  .|...::|||..::.|.|:|:||.|||||:|::|.:|
  Fly   308 YAFRQNKWRHLGSDELLPGDLVSITRSQNDNIVPCDLVILRGSCIVDESMLTGESVPLMKESLES 372

Human   357 ---------PEGLGPYCAETHRRHTLFCGTLILQARAYVGPHV-------LAVVTRTGFCTAKGG 405
                     .||.|       :...||.||.::|..|.....:       :..|.||||.|::|.
  Fly   373 LDNLDVEMDAEGDG-------KLFVLFGGTKVVQHTAPTKESLRAPDGGCIGYVIRTGFNTSQGK 430

Human   406 LVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFIL-----YRNRVPLNEIVIRALDLVT 465
            |:.:||.......:....:..|:|.|.|.|:....| :::.     .|||.   ::.:....::|
  Fly   431 LLRTILFGANRATENNVETFAFIAFLMVFAVAAASY-VWVKGSEDPERNRY---KLFLECTLILT 491

Human   466 VVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPL 530
            .::||.||..:|:....:..:|.:..:||..|.||...||:|:.|||||||||.|.|.|.|:.
  Fly   492 SIIPPDLPIELTLAVNTSLIQLTKLFVFCTEPFRIPFAGKVQICCFDKTGTLTTDNLMVEGIA-- 554

Human   531 KGQAFLPLVPEPRRLPV----GPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAAD 591
                  .|.|....:|:    |..::.||.||:|:.|.|..||||::...:.:..|.|.:   .|
  Fly   555 ------GLAPNGACVPIEKAEGNTVQVLACCHSLALLDDGLVGDPLEKATLAAVDWTLTK---MD 610

Human   592 SAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSV----VVAWPGATQPEAYV 652
            |....:           ||.:       |:.::.|:.|||||:||||    ::.:....:....|
  Fly   611 SVIPKR-----------PQFK-------PLKIIQRYHFSSALKRMSVLAGHLIPYSNEVKHIGAV 657

Human   653 KGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSL 717
            ||:||::..:.  ..||.|:.::...|...|.||:||..|.|.|: ..:..:::.|:.||.||:.
  Fly   658 KGAPEVIQKML--REVPADYEKVYLEYARRGARVLALGIKDLGTL-GAQRVREMKREEVECDLTF 719

Human   718 LGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPER 782
            .|.|::...:||.:..||:.|.::..:.||:|||:..||..|||.....  ::.|||:  |.||.
  Fly   720 AGFLIISCPMKPDSKSVIKELIQSSHKVVMITGDSPLTACHVARELRFT--RKKLIIL--TPPEE 780

Human   783 GQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLA---------LSGPTFGIIVKHFPK 838
            .:..:..::.:          |.||  ||.::..|.|:.|:         ::|.....:.::.|:
  Fly   781 DRKNNWSWVSI----------DGDQ--SYELDTKPGSKKLSHLLATHDLCITGEGLQYLQQNQPQ 833

Human   839 LLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL--------- 894
            .:.::|.|.||.||.||:||..::.:|::|.||..|||||.||.||||.|:||:||
  Fly   834 YMRQLLPQITVCARFAPKQKELVITQLKQLGYCTLMCGDGTNDVGALKHANVGVSLLTSAPVKRK 898

Human   895 --------------------------------------------SQA------------------ 897
                                                        :||
  Fly   899 RTEEEQQQAAANAAAIAAQAQANANQQLTTRERALRRRQEHLNQTQARLQNALRDMEEQTMVKLG 963

Human   898 EASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQF 962
            :||:.:||||..:||.||..:|::|||:|.|:..:||.:||.:|.|.....:||.......|.|
  Fly   964 DASIAAPFTSKSSSIMCVNHIIKQGRCTLVTTLQMFKILALNALIQAYCQSVLYIDGIKFSDTQ- 1027

Human   963 LAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLT----- 1022
            ..:..:......:.::|..|...|.:|.|...:.:...:|::|.|..:..|..   |:||
  Fly  1028 ATMQGIFIAACFLFITRAKPLKTLSKVAPLPNIFNFYTISTILSQFAVHFGTL---YYLTSQANI 1089

Human  1023 LAQP--WFVPLNRTVAAPDNL---PNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            ||.|  ..|.|...:.|.:..   ||..::.|:.:.....:...|...||.||...|.:|
  Fly  1090 LAPPREGKVKLYIDMDAEEKTKYDPNIVSSTVYIICLSLQVATIAVNYKGYPFMESLRSN 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	308/1163 (26%)
CG6230	NP_609490.1	P-type_ATPase_cation	220..1152	CDD:319843	274/997 (27%)