Protein Alignment ATP13A2 and catp-5

DIOPT Version :10

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: NP_001309699.1
• Gene: catp-5 / 181067
• WormBaseID: WBGene00019493
• Length: 1202
• Species: Caenorhabditis elegans
• Alignment Length: 1120
• Identity: 407/1120 - (36%)
• Similarity: 601/1120 - (53%)
• Gaps: 123/1120 - (10%)

Human     6 SPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPL----LLFR 66
            :|...:|....|.|.||.....|.:...:             ||..::.|::..:.|    ||..
 Worm    35 NPKAKTTSFNQGKLNIGEETCDLYAYKET-------------IGRQILFWLLTIVTLGFYQLLAY 86

Human    67 WKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQ 131
            |.....|::|.:|  .:|.|...:.:.|...:                       |:..|..:::
 Worm    87 WVKSLFVKVRFQP--TSHDECEYVMVEDIHGT-----------------------QTIKEVFKAE 126

Human   132 AAVG-AVPEGAWKDTAQLHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCD- 194
            :.|| |.|..:.|        :|.|    :|:|::.::..:|||.|..|.:...:.:|.....:
 Worm   127 SDVGLARPTRSGK--------QEKV----KVMRFFTYRKIKYIWYEKDQEWLNPADMDSAAPFNI 179

Human   195 ------DVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLAD 253
                  ||    .||..||.:..:.||..|.:::.:.....:|..|.|.|:|.||.||:|||.:|
 Worm   180 YQKLTLDV----IGLKEQDVIASRKIYNMNALALALTPILVILFKEVLGPFYLFQCFSVALWYSD 240

Human   254 HYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLV 318
            :|.:||..|.:|:..|..:::|:.|.|.:.:|:||..::.|.| |..|.:..:|:||:||.|.|:
 Worm   241 NYAYYASVIVIITVGSAAVAVYQMRAQEKRIRNMVGDTISVIV-RRDGHDITIDASEIVPMDILI 304

Human   319 LPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEG--LGP--YCAETHRRHTLFCGTLI 379
            ||....::|||..|:.|..:|||:.|||||:||.|.:|.|.  .||  ..:..|.|||||.||.:
 Worm   305 LPSNTFILPCDCLLMNGTVIVNEAMLTGESVPVTKASLKEADECGPEIRLSSEHNRHTLFSGTTV 369

Human   380 LQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIF 444
            ||.|.|.|..|:|.|.||||.|.||.||.||::|:|...:..|..|.|:..|..:||:|.||::.
 Worm   370 LQTRNYKGQPVMARVIRTGFSTLKGQLVRSIMYPKPQEKEALKDVMVFILVLGFIALIGFIYTVI 434

Human   445 ILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLV 509
            .:......|..|:||:||::|:||||||||||:|..:.|.|||:::.|||..|..:|:.|.:.:.
 Worm   435 EMVSRGESLKHIIIRSLDIITIVVPPALPAAMSVGIINANSRLKKKKIFCTSPTTVNVCGLINVA 499

Human   510 CFDKTGTLTEDGLDVMGVVPLK---------GQAFLPLVP-----EPRRLPVGPLLRALATCHAL 560
            ||||||||||||||...:..::         ...|..|.|     |...|.:   :.|.|:||:|
 Worm   500 CFDKTGTLTEDGLDFNCLKAIRKNEDGKPEFTSEFEELDPVKLSAENANLNI---VVAAASCHSL 561

Human   561 SRLQDTPVGDPMDLKMVESTGWVLEEEPAADSA---FGTQVLAVMRPPLWEPQLQAMEEPPVPVS 622
            :|:..|..|||::|.:||.:.|::||...:|..   |.|....|:|||   |:...........|
 Worm   562 TRIDGTLHGDPLELILVEKSKWIIEEAVNSDEETQDFDTVQPTVLRPP---PEQATYHPENNEYS 623

Human   623 VLHRFPFSSALQRMSVVVAWP---GATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGY 684
            |:.:.||:||||||||:::.|   .|.....:.|||||::|.||.|:|:|.|:.:::..|...|:
 Worm   624 VIKQHPFNSALQRMSVIISTPSEHSAHDMMVFTKGSPEMIASLCIPDTIPEDYMEVVDEYAQRGF 688

Human   685 RVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVT 749
            |::|:|||.:..  :...|.:..||.:|.:|..|||:||.|.||..|..||..|....||.||||
 Worm   689 RLIAVASKAVHL--NFAKALKTPRDIMESELEFLGLIVMENRLKDVTLSVINELSVANIRCVMVT 751

Human   750 GDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPD-------- 806
            ||||.||::|||.||::.|.:...::..:..|:......:....||.::.....|.|
 Worm   752 GDNLLTAMSVARECGIIRPTKKAFLITHSKTEKDPLGRTKLFIKESVSSSENDIDTDSEVRAFDR 816

Human   807 ----QAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQK 867
                :.|:|         .:|::|||:.:|...:|:|:.::.....|:|||||:||.:|:..||:
 Worm   817 KAVLRTATY---------QMAIAGPTYSVITHEYPELVDRITAMCDVYARMAPDQKAQLIGALQE 872

Human   868 LQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSV 932
            :...|.|||||||||.|||||..||||||||||:.:||||::..|.|||.||:||||:|.||::|
 Worm   873 IGAKVSMCGDGANDCAALKAAHAGISLSQAEASIAAPFTSNVPDIRCVPTVIKEGRCALVTSYAV 937

Human   933 FKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLS 997
            .||||.|||.:|:||::||...||:.|.|||.||||:.|.||:.:..|..:..|..:.||..|.:
 Worm   938 SKYMAAYSLNEFLSVMLLYNDGTNISDGQFLYIDLVLITLVALFLGNTEASRKLSGIPPPRRLAT 1002

Human   998 VPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAA 1062
            .....|:..||......|..||.|...|.|:||....:   ||......|.||..|...||..|.
 Worm  1003 SAFYFSVFGQMFFNIITQTTGYLLVRGQSWYVPNPEEL---DNTTTMIGTTVFFTSCCMYLGYAF 1064

Human  1063 AVSKGAPFRRPLYTN 1077
            ..|||.|:||.::||
 Worm  1065 VYSKGHPYRRSVFTN 1079

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	398/1085 (37%)
catp-5	NP_001309699.1	P5-ATPase	52..158	CDD:463565	26/155 (17%)
		P-type_ATPase_cation	193..1050	CDD:319842	351/877 (40%)