Protein Alignment ATP13A2 and catp-6

DIOPT Version :9

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: NP_001255430.2
• Gene: catp-6 / 177822
• WormBaseID: WBGene00012341
• Length: 1267
• Species: Caenorhabditis elegans
• Alignment Length: 1126
• Identity: 422/1126 - (37%)
• Similarity: 617/1126 - (54%)
• Gaps: 121/1126 - (10%)

Human    28 LSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEI 92
            |.|...::.|..|...|:|.|.::.:..:..||..|:..||..|.|::|:.||....||.:.|
 Worm    14 LESGDHTLTLFAYRTGPFRTILFYALTVLTLGIFRLILHWKQKWDVKMRMVPCTFEAAEYIYI-- 76

Human    93 RDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSV 157
                          :....:.|  |:|..:      :|.|.:..       :..::.|..|
 Worm    77 --------------IDNHNVSE--LQPVLR------KSNATIPT-------ENGEMRKVPE---- 108

Human   158 GQRVLRYYLFQGQRYIWIE---TQQAFYQVSLLDH-------------GRSCDDVHRSRHGLSLQ 206
                ||:::::...|:||:   :.::..::|..|:             .||...|..|..||:|.
 Worm   109 ----LRWFVYRKLEYVWIDDLNSDESVDEISDNDNCWKTSFEIANRIPCRSLLAVSESNFGLTLS 169

Human   207 DQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISIC 271
            :...|...||.|.|.:.::....|||.|.:.|:|.||.||:.:|..|.|.:||..|.::|..||.
 Worm   170 EISRRLEFYGRNEIVVQLRPILYLLVMEVITPFYVFQIFSVTVWYNDEYAYYASLIVILSLGSIV 234

Human   272 LSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGE 336
            :.:|:.|.|...||.||..:..|.|.|. |.|..:.|.:|||||.|::|..|.||.||:.|:.|.
 Worm   235 MDVYQIRTQEIRLRSMVHSTESVEVIRE-GTEMTIGSDQLVPGDILLIPPHGCLMQCDSVLMNGT 298

Human   337 CMVNESSLTGESIPVLKTALPEGLGP--YCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGF 399
            .:||||.|||||:|:.|.||.:....  :..|.:.::.|||||.:||.|.|.|..|.|:|.||.:
 Worm   299 VIVNESVLTGESVPITKVALTDETNDSVFNIEKNSKNVLFCGTQVLQTRFYRGKKVKAIVLRTAY 363

Human   400 CTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLV 464
            .|.||.||.||::|:|::|:|.|...||:..|:.::..|.||:|.::......|..|::|:||::
 Worm   364 STLKGQLVRSIMYPKPVDFRFTKDLFKFILFLACISGCGFIYTIIVMIMRGNTLRRIIVRSLDII 428

Human   465 TVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVP 529
            |:.|||||||||:|..:.||.||:::.||||.|..||..|.:.:|||||||||||||||...|.|
 Worm   429 TITVPPALPAAMSVGIINAQLRLKKKEIFCISPSTINTCGAINVVCFDKTGTLTEDGLDFHVVRP 493

Human   530 LKGQA----------------FLPLVPE---PRRLPV-GPLLRALATCHALSRLQDTPVGDPMDL 574
            :....                |:..:.|   ...||. |.|::|:||||:|:|:.....|||:||
 Worm   494 VMSAVNQEIQKVKLEKSNRTEFMGEMTELTSRNGLPFDGDLVKAIATCHSLTRINGVLHGDPLDL 558

Human   575 KMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVV 639
            .:.:.|||.:||....|....||....::|.:.:|    .::.....||:.:|.|||:||||||:
 Worm   559 ILFQKTGWTMEEGIEGDIEEETQRFDNVQPSIIKP----TDDKSAEYSVIRQFTFSSSLQRMSVI 619

Human   640 VAWPGATQPE---AYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLE 701
            |..|...:|:   .|.|||||::..||:|.|||.|:...:.||...|:|::|:|.:||..  :..
 Worm   620 VFDPREDRPDNMMLYSKGSPEMILSLCDPNTVPEDYLLQVNSYAQHGFRLIAVARRPLDL--NFN 682

Human   702 AAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMV 766
            .|.::.||.||.||.:|||:||.|.:||.|..||..|.|..||.||||||||.|.::|||.||::
 Worm   683 KASKVKRDAVECDLEMLGLIVMENRVKPVTLGVINQLNRANIRTVMVTGDNLLTGLSVARECGII 747

Human   767 APQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTV------------------ 813
            .|.:...:|.....|..:....:....:|.::.:.|.:.|.:.|.::
 Worm   748 RPSKRAFLVEHVPGELDEYGRTKIFVKQSVSSSDEVIEDDASVSISMCSSTWKGSSEGDGFSPTN 812

Human   814 ----EPDP-----------RSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVC 863
                .|:|           .|.|||:|||||.:||..:|:|:.::.....|||||||:||..||.
 Worm   813 TEVETPNPVTADSLGHLIASSYHLAISGPTFAVIVHEYPELVDQLCSVCDVFARMAPDQKQSLVE 877

Human   864 ELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDT 928
            :||::.|.|.|||||||||.|||||..|||||.||||:.:||||.:..|.|||.||.|||.:|.|
 Worm   878 QLQQIDYTVAMCGDGANDCAALKAAHAGISLSDAEASIAAPFTSKVPDIRCVPTVISEGRAALVT 942

Human   929 SFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPG 993
            ||.:|||||.||||||::|:.||.|:..|.|.||:.||:.:.|..|:|...|.....|....||.
 Worm   943 SFGIFKYMAGYSLTQFVTVMHLYWISNILTDGQFMYIDMFLITMFALLFGNTPAFYRLAHTPPPT 1007

Human   994 ALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTV-AAPDNLPNYENTVVFSLSSFQY 1057
            .|||:..::|::.|::::..||...:|.|..||||.|....| ...::..:.:.|.:|.:|.|||
 Worm  1008 RLLSIASMTSVVGQLIIIGVVQFIVFFSTSQQPWFTPYQPPVDDEVEDKRSMQGTALFCVSMFQY 1072

Human  1058 LILAAAVSKGAPFRRPLYTNE 1078
            :|||...|||.|||..|::|:
 Worm  1073 IILALVYSKGPPFRGNLWSNK 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	418/1112 (38%)
		P5-ATPase	39..>114	CDD:289194	17/74 (23%)
		E1-E2_ATPase	262..497	CDD:278548	103/236 (44%)
		Cation_ATPase	<627..663	CDD:289987	19/38 (50%)
		COG4087	<849..>898	CDD:226572	34/48 (71%)
catp-6	NP_001255430.2	P-ATPase-V	18..1137	CDD:273738	420/1122 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161448536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54176
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	1	1.000	-	-		mtm4892
orthoMCL	1	0.900	-	-		OOG6_100379
Panther	1	1.100	-	-	O	PTHR45630
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R101
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890