Protein Alignment ATP13A2 and atp13a2

DIOPT Version :10

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: XP_031761296.1
• Gene: atp13a2 / 116412065
• XenbaseID: XB-GENE-996840
• Length: 1179
• Species: Xenopus tropicalis
• Alignment Length: 1094
• Identity: 578/1094 - (52%)
• Similarity: 749/1094 - (68%)
• Gaps: 45/1094 - (4%)

Human     1 MSADSSPLVG-STPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLL 64
            |..|:|.|:| ..|.|||||       |.....|.:.:.||....|:::...::..:..|:.||.
 Frog     1 METDNSRLLGPQKPGGYGTL-------PPCEFRSCMEIRGYRRITWKLVLCCILCVLTLGVLLLF 58

Human    65 FRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQ-AEDG 128
            |.|||...|.|..|.|.||.|..|||     :|...|:...:|:.|...:.||.|....: ..:|
 Frog    59 FHWKPRLYVLLTCRHCPLAEANWLVI-----KDEFGQISIAEVRVEQGMDVSLGPYMTGRLGING 118

Human   129 RSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSC 193
            .....:|...:..:|||.|||..||     ...|||::|:|.||:|....|.|.:||.||.|.:|
 Frog   119 GGSVIIGVEDQEDFKDTIQLHHKEE-----NNALRYFVFEGMRYVWSNRTQNFVRVSSLDEGVTC 178

Human   194 DDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWY 258
            .::|:.:.||:..:...||.|:|.|.|.:|||||.:||::|.|||:|.||.|||.||:.|:||:|
 Frog   179 GELHKKKFGLNQTEHNTRKQIFGANEIDVPVKSYGRLLIEEVLNPFYIFQVFSIVLWMCDNYYYY 243

Human   259 ALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEG 323
            :.||.:||.|||.||||:|||||.|||:|||:.:.|.|.|..|||..|:|.:||||||::||.||
 Frog   244 SACILVISIISISLSLYETRKQSVTLRNMVKMQVSVKVRRDTGEEMLVNSPDLVPGDCIILPPEG 308

Human   324 GLMPCDAALVAGECMVNESSLTGESIPVLKTALPE----GLGPYCAETHRRHTLFCGTLILQARA 384
            .||||||||:.||||||||.|||||:|.:||.|.:    |..|||.|.|:|||||.||.|:||::
 Frog   309 ILMPCDAALLTGECMVNESMLTGESVPEMKTPLTDGPQAGRTPYCPEEHKRHTLFGGTQIIQAKS 373

Human   385 YVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRN 449
            |:...|:||||||||||.||.|:||||||:|::||||:.::|||..|.:.|.||.:|:|.||.||
 Frog   374 YLEKEVIAVVTRTGFCTVKGNLISSILHPKPVSFKFYRDAVKFVLVLGLFAFLGNVYTIGILIRN 438

Human   450 RVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKT 514
            :..::.|||:.|||:|::|||||||||||.|:||||||::||||||.|.|||:.||::::|||||
 Frog   439 KSTVSRIVIQTLDLITIIVPPALPAAMTVGTIYAQSRLKKQGIFCISPPRINVCGKIKMICFDKT 503

Human   515 GTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVES 579
            |||||:||||.|||||....|||:..:||.||.||.|.:||:||:::.|:.:|:||.||:||:||
 Frog   504 GTLTEEGLDVWGVVPLDNTNFLPITHDPRCLPDGPFLHSLASCHSVTLLKGSPIGDLMDVKMMES 568

Human   580 TGWVLEEEPAADSA---FGTQVLAVMRPPLWEPQLQAMEEPP------VPVSVLHRFPFSSALQR 635
            |.|.|:.:...:..   |||:|||||:||       .::|.|      ||:.||.||||||||||
 Frog   569 TNWTLDSQDTDEQMTEHFGTKVLAVMKPP-------PIDEQPHGPKHHVPIGVLRRFPFSSALQR 626

Human   636 MSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSL 700
            |||:...||.:....|:||:||:||.||..:|||.||:.||:.||..||||:....|.|.:|.:.
 Frog   627 MSVISKLPGDSPSHLYMKGAPEMVASLCKSDTVPPDFSAMLKQYTKDGYRVLGFGYKTLSSVKTF 691

Human   701 EAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGM 765
            |.||.:.|::||.|||.||.|:|:|:|||:|.|||..|||..||.|||||||:.|||.||..|.:
 Frog   692 EDAQLVARESVEQDLSFLGFLIMKNVLKPETAPVIHELRRANIRTVMVTGDNMLTAVNVAGSCHI 756

Human   766 VAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDP--DQAASYTVEPDPRSRHLALSGPT 828
            |...|.:.....:.|...:.|||.|:|.: |..:.|.::.  .|..::.   |......|::|.:
 Frog   757 VGVTEKVYFASVSPPSLNKAASLRFIPAD-PAPMEGAQEALYQQGGAFL---DKGPYCFAMNGKS 817

Human   829 FGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGIS 893
            |..:..|||.||||:||:..:||||:|:|||:||...|.|.||||||||||||||||||||||:|
 Frog   818 FAALCDHFPDLLPKILVRSAIFARMSPDQKTQLVQNFQNLNYCVGMCGDGANDCGALKAADVGVS 882

Human   894 LSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLG 958
            ||.|||||.|||||..::|||||.:||||||||:|||.:|||||||||||||:.|||||:|||||
 Frog   883 LSDAEASVASPFTSRTSNIECVPALIREGRCSLETSFVMFKYMALYSLTQFITALILYTVNTNLG 947

Human   959 DLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTL 1023
            |||||..||||||.||:||.|||||..||..||.|:|:|:|||.||:||.:|:..:||...||..
 Frog   948 DLQFLYFDLVITTLVAILMGRTGPAAELGIKRPLGSLISIPVLGSLVLQTILILIIQLIPLFLVQ 1012

Human  1024 AQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
            .|.||||:|.|.....:||||||||:|.:|.|||:|||..:|||.|||:.||||
 Frog  1013 NQSWFVPVNVTNPQTVHLPNYENTVLFCVSGFQYIILAVVLSKGYPFRKALYTN 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	563/1053 (53%)
atp13a2	XP_031761296.1	P-ATPase-V	29..1098	CDD:273738	565/1059 (53%)