Protein Alignment ATP13A2 and atp13a3

DIOPT Version :9

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: XP_031757979.1
• Gene: atp13a3 / 100497750
• XenbaseID: XB-GENE-6045268
• Length: 1247
• Species: Xenopus tropicalis
• Alignment Length: 1107
• Identity: 481/1107 - (43%)
• Similarity: 659/1107 - (59%)
• Gaps: 108/1107 - (9%)

Human    49 GYHVVVWMMA----------GIPLLLFRWKPLWGV-----RLRLRPCNLAHAETLVIEIRDKEDS 98
            ||::..|.:|          |..|||..|.|.|.|     |:.|:.|::....|        .|.
 Frog    19 GYNLCRWKLALVAIGVLCSGGFLLLLLYWMPKWRVKATCTRVTLKDCDVVLLRT--------TDE 75

Human    99 SWQLFTVQVQTEAIGEGSLEP------SPQSQAEDGR-SQAAVGAVPEGAWKD---------TAQ 147
            ..|.|..:|:.      .|.|      .|:|.|  |: :...:|.:||...:.         |..
 Frog    76 FRQWFCAKVRI------LLSPVTHPFQIPESVA--GKVTNGHIGHLPESHTEHHEDHPMNNATVP 132

Human   148 LHKSEEAVSVGQRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSR-HGLSLQDQMVR 211
            ||:           :||::.....|.|.:..|.|.....||.|..|..:||.. .||..:....|
 Frog   133 LHE-----------VRYFVHHSLTYYWNDVHQTFSLFKGLDEGIQCSAMHREHSQGLCKEIHDYR 186

Human   212 KAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYK 276
            |..||.|.|::.|.|..:|||.|.|||:|.||.||:.||..|.||:||..|.|:|.|||..|||.
 Frog   187 KLFYGINEITVKVPSLFKLLVKEVLNPFYIFQLFSVILWCTDEYYYYASAILLMSVISIISSLYT 251

Human   277 TRKQSQTLRDMVKLS--MRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMV 339
            .:||...|.|||...  :||.|.|...|.|.:.|::|||||.:::|..|.:|||||.|::|.|:|
 Frog   252 IKKQYIMLHDMVSAHSIVRVSVYRGKKEAEEILSTDLVPGDIMLIPPNGTIMPCDAVLISGTCIV 316

Human   340 NESSLTGESIPVLKTALP----EGLGP----YCAETHRRHTLFCGTLILQARAYVGPHVLAVVTR 396
            |||.|||||:||.||.||    :...|    |..|.|:||||||||.::|.|.|.|..|.|::.|
 Frog   317 NESMLTGESVPVTKTNLPDPTTDSRAPENEIYSTEIHKRHTLFCGTNVIQTRFYAGESVKAIIVR 381

Human   397 TGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRAL 461
            |||.|:||.|:.:||:|:|.:||.|:.:..|:..|..:|.:|.:|:|.....|:||...|:|.:|
 Frog   382 TGFSTSKGQLIRAILYPKPTDFKLYRDAYLFLLCLVAVAGIGFLYTIINSILNKVPAGIIIIESL 446

Human   462 DLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMG 526
            |::|:.||||||||||...:|||.||:..|||||.|.|||:.|:|.|:||||||||||||||:.|
 Frog   447 DIITITVPPALPAAMTAGIVYAQKRLKNLGIFCISPQRINICGQLNLICFDKTGTLTEDGLDLWG 511

Human   527 VVPLKGQAFLPLVPEPR----RLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEE 587
            :..::...|  |:||.:    .|.....:..:||||:|:::.....|||:||||.|:.||:|||.
 Frog   512 IQRVEDARF--LLPEEKACSESLVKSQFVACMATCHSLTKIDGVLSGDPLDLKMFEAIGWILEEA 574

Human   588 PAADSAFGTQVL-AVMRPPLWEP-------QLQAMEEPPVP----VSVLHRFPFSSALQRMSVVV 640
            ...::|...::: .|::||. :|       ..|.||...:|    :.::.:||||||||||:||.
 Frog   575 TEEETALHNKMMPTVVQPPK-QPVTDQKPAASQEMELFEIPTTYEIGIVRQFPFSSALQRMAVVA 638

Human   641 AWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQ 705
            ...|..:.:|||||:||::|.||..||||.|||.:|:.||..||||:|||.:.|.:..|....|.
 Frog   639 RILGEKKMDAYVKGAPEVIASLCKQETVPHDFASVLEEYTKQGYRVIALAHRKLESKISWHKVQN 703

Human   706 LTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQE 770
            ::||.:|.:::.|||::|:|.||.:|..|::.||...||.|||||||:.||::|||.|||:.|||
 Frog   704 ISRDAIESNMTFLGLIIMQNKLKEETPSVLEDLRNANIRTVMVTGDNMLTAISVARDCGMILPQE 768

Human   771 HLIIVHATHPERGQPASLEF-----LPMESPTAVNGVKDPDQAASYTVEPD-PRSRHLALSGPTF 829
            .:|:..|..|:.|:.|::.:     ||..|...::....|.:..|.::|.: ..:.|.|::|.:|
 Frog   769 KVIVAEALPPKDGRVATISWHYADSLPRSSLNTIDSEDIPVKVVSDSLEDNYVANYHFAMNGKSF 833

Human   830 GIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISL 894
            |:|::|||.|:||:::.|||||||||:|||:||.|||.:.|.|||||||||||||||.|..||||
 Frog   834 GVILEHFPDLVPKLVLHGTVFARMAPDQKTQLVEELQNVDYYVGMCGDGANDCGALKRAHGGISL 898

Human   895 SQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGD 959
            |:.||||.|||||...||.|||.:|||||.:|.|||.|||:||||||.|:.||.:||:|.:||||
 Frog   899 SELEASVASPFTSRTPSISCVPNLIREGRAALITSFCVFKFMALYSLIQYFSVTLLYSILSNLGD 963

Human   960 LQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLA 1024
            .|||.|||.|...|...||......||...|||..|:|.|:|.|:|.|:::..|.|...:.....
 Frog   964 FQFLFIDLAIILIVVFTMSLNPAWKVLVAQRPPSGLISGPLLFSVLSQILICLGFQTWAFLWVKE 1028

Human  1025 QPWF---VPLNR--TVAA---------PDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLY 1075
            |||:   :|.:.  .|:|         ..|:.|||||.:|.:|||||||:|...|||.|||:|.|
 Frog  1029 QPWYEVWIPNSNVCNVSADLHYDNHTDEHNIKNYENTTLFYVSSFQYLIVAIVFSKGKPFRQPSY 1093

Human  1076 TN 1077
            .|
 Frog  1094 KN 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	480/1105 (43%)
		P5-ATPase	39..>114	CDD:289194	20/79 (25%)
		E1-E2_ATPase	262..497	CDD:278548	119/244 (49%)
		Cation_ATPase	<627..663	CDD:289987	21/35 (60%)
		COG4087	<849..>898	CDD:226572	37/48 (77%)
atp13a3	XP_031757979.1	P-ATPase-V	12..1140	CDD:273738	481/1107 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I31733
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	1	1.000	-	-		FOG0000757
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X554
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010