Protein Alignment ATP13A2 and atp13a5

DIOPT Version :9

• Sequence 1: XP_005245867.1
• Gene: ATP13A2 / 23400
• HGNCID: 30213
• Length: 1201
• Species: Homo sapiens
• Sequence 2: XP_012818836.2
• Gene: atp13a5 / 100485018
• XenbaseID: XB-GENE-12441880
• Length: 1197
• Species: Xenopus tropicalis
• Alignment Length: 1086
• Identity: 432/1086 - (39%)
• Similarity: 619/1086 - (56%)
• Gaps: 94/1086 - (8%)

Human    47 VIGYHVVVWMMA----------GIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRD--KEDSS 99
            :.||..::|...          |:..|||.|||.|.|.....||.|.:|...::...|  |..|.
 Frog    23 IFGYRTILWRKGLCIMGYIFSFGLLWLLFYWKPEWEVWAYCEPCLLENANVFLLRSTDEFKHCSK 87

Human   100 WQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQRVLRY 164
            ..|....:        |.:.|...|..|..|.           ||...:  ..:|:.:.:..:||
 Frog    88 KNLLWTHL--------SKQDSVLLQTSDKLST-----------KDEYSI--INKAIMMPEHKVRY 131

Human   165 YLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVH-RSRHGLSLQDQMVRKAIYGPNVISIPVKSYP 228
            ...|..:|:|:.:::.|.:...|:...||..:| |...||:.::|.:|:.|.|||.|.:.|....
 Frog   132 IRVQKIKYVWLLSEKKFQKAGALEDLYSCSQIHSRFGSGLTQEEQTLRRLICGPNAIEVEVVPVW 196

Human   229 QLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKL--S 291
            :||..|.|||:|.||..|::||||:.|..|::.|.:|:.||:.|::|..|:||..|..:|:.  |
 Frog   197 KLLFKEVLNPFYLFQIASLSLWLAEGYIEYSVVIIIITLISVILTVYDLRQQSVKLNRLVESNNS 261

Human   292 MRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTAL 356
            ..|.|....|:...|:|.:|||||.:||..:...:|||..|:.|.|:|||..||||||||.||.|
 Frog   262 ASVTVLMKDGDSYDVESRQLVPGDIIVLTGKRFFLPCDCILLEGSCIVNEGMLTGESIPVTKTPL 326

Human   357 --PEGLGPY---CAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPI 416
              .|...|:   ..|.::||.|||||.::||.:.....|.|||.:|||.||||.:|.|||:|:|:
 Frog   327 DRSESAKPWKIQSGEDYKRHVLFCGTEVIQATSTGADPVTAVVVQTGFNTAKGDMVRSILYPKPM 391

Human   417 NFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTL 481
            |||.|:.:::|:..|.|:|.:|.|||:.:.......:.:|:|:::..:||.:||.||||:....:
 Frog   392 NFKLYQDALRFLMCLVVIAAVGFIYSVIVFKVKGASVRDIIIKSIIAITVAIPPILPAAVATALM 456

Human   482 YAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAF--LPLVPEPRR 544
            |:|.||:::.||||.|.|||:.|::.||||||||||||||||:.||:|.....|  |.:..:...
 Frog   457 YSQKRLKKKKIFCISPQRINVCGRVNLVCFDKTGTLTEDGLDLWGVIPCTENRFQKLHMFADGND 521

Human   545 LPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEP 609
            ||..|||.|:|:||:|..|.....|||:|:||.|.|.|::|:....::  ....|.:...|...
 Frog   522 LPWCPLLGAMASCHSLLILDGKIQGDPLDVKMFEGTNWIIEDSNTENN--HNHNLLIKPGPRCS- 583

Human   610 QLQAMEEPPVPV---SVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTD 671
                    ||||   ::|.:|||||:||||||:.....:.:...::||:||:|...|.||:||.:
 Frog   584 --------PVPVKGITILQQFPFSSSLQRMSVIAQAIESEENMVFMKGAPEMVTQFCLPESVPAN 640

Human   672 FAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQ 736
            ||..||.||..||||:.||.|||...........| |:.||..|..||||::.|.||.:|.|.:.
 Frog   641 FANELQLYTQQGYRVIGLAYKPLQACDKGHKENYL-REEVECSLIFLGLLILENRLKTETIPALN 704

Human   737 ALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNG 801
            .|....|:.||:||||||||:||||.||:|.....:|:..|:.|....|||:.:..:|  |.::.
 Frog   705 ELNNALIKTVMITGDNLQTAITVARSCGIVQRHGRVILAEASEPNGSIPASITWKEVE--TNLHV 767

Human   802 VKDPDQAASYTVEPDPRS-------RHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKT 859
            |.|..:    |.:|:..|       .:.|:||.|:||||::|..||||:|:.|.:||||:|.||.
 Frog   768 VHDNTE----TTDPEKNSDAQKSCPYYFAMSGKTYGIIVQYFYSLLPKLLLNGAIFARMSPGQKA 828

Human   860 ELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRC 924
            .|:.|.|||.|.|.|||||||||||||.|..|||||:.||||.|||||..|:|.|||.:|:|||.
 Frog   829 NLIEEFQKLDYYVAMCGDGANDCGALKMAHAGISLSEQEASVASPFTSQTANILCVPQLIKEGRA 893

Human   925 SLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRV 989
            :|.:||:||||:.|||:.|||.:|:||.....:|..|:|..|:.||..|::.:|.|.|...|...
 Frog   894 ALVSSFAVFKYVTLYSMIQFICMLLLYWKLKMVGLYQYLFQDVGITILVSLTLSLTHPYQKLAPY 958

Human   990 RPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAP--DNL----------- 1041
            |||..|:|.|:|.|::..::|....|:.|:.|...|||:...|....||  :|:
 Frog   959 RPPAQLISPPLLLSIIFNILLSLASQICGFLLVQQQPWYSTSNYRACAPTTENITAVGFNISNTN 1023

Human  1042 ----------PNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTN 1077
                      .|||:|.::.:::...:|:|...|||.|||:|:|||
 Frog  1024 STGVEENPEFENYESTTLWPITTINLIIVAFVFSKGTPFRKPIYTN 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP13A2	XP_005245867.1	P-ATPase-V	39..1077	CDD:273738	430/1084 (40%)
		P5-ATPase	39..>114	CDD:289194	20/78 (26%)
		E1-E2_ATPase	262..497	CDD:278548	103/241 (43%)
		Cation_ATPase	<627..663	CDD:289987	16/35 (46%)
		COG4087	<849..>898	CDD:226572	33/48 (69%)
atp13a5	XP_012818836.2	P5-ATPase	18..141	CDD:403569	32/138 (23%)
		P-type_ATPase_cation	174..997	CDD:319842	370/840 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172453at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010