DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZDHHC17 and Hip14

DIOPT Version :10

Sequence 1:NP_056151.2 Gene:ZDHHC17 / 23390 HGNCID:18412 Length:632 Species:Homo sapiens
Sequence 2:NP_001261910.1 Gene:Hip14 / 39747 FlyBaseID:FBgn0259824 Length:655 Species:Drosophila melanogaster


Alignment Length:576 Identity:284/576 - (49%)
Similarity:382/576 - (66%) Gaps:17/576 - (2%)


- Green bases have known domain annotations that are detailed below.


Human    55 DYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQL 119
            |||.:|||||||||...|.|||||:|:||.|||.|.||||||||||||.|:::|::.|||.||.:
  Fly    43 DYSGFDIVKATQYGAIARVRELVESGWDVNQPDSETVTLLHWAAINNRRDIIRYFLEKGATVDAV 107

Human   120 GGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD 184
            ||:||:||||||||||||..||.||..||||.:.|.|||||||:||||.||::|||.||||.|.|
  Fly   108 GGELNATPLHWATRQGHLGAVVLLMAAGADPRIRDAEGCSCIHIAAQFAHTALVAYFIAKGVDPD 172

Human   185 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVIS-LLLEAG 248
            :.|:.|||.|||||::..::||.|||||...:..:.|..|.|||||||:||.|.|.|| |:|::.
  Fly   173 LQDRGGMTALMWAAWKVCALDPVRLLLTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSK 237

Human   249 ANVDAQNIKGESALD-LAKQRKNVW----MINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLG 308
            |::|..|::||:.|. |..|...:|    :::.::|| ........|.|.||:.||..|...|:.
  Fly   238 ASLDVPNLRGETPLSMLESQTGAIWIGAKVMDRVKEA-ALTSQQRRSLLSKLRHDKRLRWWSMVA 301

Human   309 TPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVT 373
            .||...:|.|.:..:| ..::||..:.|.:::....:.|:.||..:.:.|||.:|||||.|.|||
  Fly   302 CPFTAFYLAGIVFTVN-TLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVT 365

Human   374 WFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSL--DLS 436
            |..:..:.::|. ..:.||.:|:.|:..|.||||.|||||:.|.||:.|||:||:|.|.:  :.:
  Fly   366 WLMYIDDAVSFT-ATVCFLISSLLLWVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPA 429

Human   437 IFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCI 501
            .|||.||:|:|:|||||.||:||:|:|||||||||||:|..||.||||:|:.||.|..||:||..
  Fly   430 SFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGS 494

Human   502 SYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNER 566
            .|:...|...:  |.|...:..|..|..|:.|:..|::.|..||.:|.:||.||:.|||:|||||
  Fly   495 KYYVNQCNVRF--DDFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNER 557

Human   567 MNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYD 622
            ||..||:||:  .....|||..|.::|::||.|..|.||.:|..|||...|  :||
  Fly   558 MNRGRYRHFQ--AKGGHSPFTRGPIQNLVDFLECSCFGLVQPKRVDWMNYY--DYD 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZDHHC17NP_056151.2 Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250|UniProtKB:Q80TN5 11..305 142/255 (56%)
ANKYR 52..307 CDD:440430 142/257 (55%)
ANK repeat 89..120 CDD:293786 20/30 (67%)
ANK repeat 122..154 CDD:293786 22/31 (71%)
ANK repeat 156..187 CDD:293786 22/30 (73%)
ANK repeat 189..221 CDD:293786 15/31 (48%)
ANK repeat 224..255 CDD:293786 18/31 (58%)
DHHC 438..568 CDD:396215 68/129 (53%)
Hip14NP_001261910.1 ANKYR <52..246 CDD:440430 120/193 (62%)
ANK repeat 77..108 CDD:293786 20/30 (67%)
ANK repeat 110..142 CDD:293786 22/31 (71%)
ANK repeat 144..175 CDD:293786 22/30 (73%)
ANK repeat 177..209 CDD:293786 15/31 (48%)
ANK repeat 212..244 CDD:293786 18/31 (58%)
DHHC 426..559 CDD:396215 68/134 (51%)

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