DRSC/TRiP Functional Genomics Resources

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Protein Alignment ZDHHC17 and CG4483

DIOPT Version :9

Sequence 1:NP_056151.2 Gene:ZDHHC17 / 23390 HGNCID:18412 Length:632 Species:Homo sapiens
Sequence 2:NP_648294.1 Gene:CG4483 / 39057 FlyBaseID:FBgn0035970 Length:435 Species:Drosophila melanogaster


Alignment Length:302 Identity:74/302 - (24%)
Similarity:108/302 - (35%) Gaps:88/302 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   370 MYVTW------FFWFW-------NDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKA---TEE 418
            :.|||      ..| |       :.||:..|.:    .:....|||.:|....||.:..   .:.
  Fly    25 LIVTWTVIHMNSMW-WAPGSSLESVLNYALIWI----QTFGTLYNFIRSLMVGPGFVPLKWHPQL 84

Human   419 QKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFM 483
            .|.|..::           ||:.|...|..||.||..||||:.|.||||||:..|||..|...| 
  Fly    85 TKDKMFLQ-----------FCTRCNGYKAPRSHHCRRCNRCVMKMDHHCPWINTCVGWSNQDSF- 137

Human   484 GYLFFLLFMICWMIYG----------------CISYWGLHCETTYTKDGFWTYITQIATCSPWMF 532
              ::||||.:...|:|                .|.|...|..|.:...      |.:..|     
  Fly   138 --VYFLLFFMSGSIHGGIIIVSAVIRGIKKRWLIRYGLRHMATVHLTQ------TNLLAC----- 189

Human   533 WMFLNSVFHF--MWVAVLLMCQMYQISCLGITTNE-------------RMNARRYKHFKVTTTSI 582
                  ||..  :...||...::..:....|..|:             |.||...|..|    ..
  Fly   190 ------VFSLGVIMGTVLASIKLLYMQMKSILKNQTEIENWIVKKAAFRRNAYPRKGIK----PF 244

Human   583 ESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQI 624
            ..|:|.|...|:.:.|.....|:..||:.| ..:|::..:|:
  Fly   245 VYPYNLGWKTNMREVFFSTGDGISWPVLPD-CNEYSLTCEQL 285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ZDHHC17NP_056151.2 Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250|UniProtKB:Q80TN5 11..305
ANK repeat 89..120 CDD:293786
Ank_2 94..187 CDD:403870
ANK repeat 122..154 CDD:293786
ANK repeat 156..187 CDD:293786
Ank_2 161..255 CDD:403870
ANK repeat 189..221 CDD:293786
ANK repeat 224..255 CDD:293786
Ank_2 229..>286 CDD:423045
DHHC 438..568 CDD:396215 43/160 (27%)
CG4483NP_648294.1 zf-DHHC 88..224 CDD:279823 43/166 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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