DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC17 and CG10344

DIOPT Version :9

Sequence 1:	NP_056151.2	Gene:	ZDHHC17 / 23390	HGNCID:	18412	Length:	632	Species:	Homo sapiens
Sequence 2:	NP_611671.1	Gene:	CG10344 / 37565	FlyBaseID:	FBgn0034729	Length:	278	Species:	Drosophila melanogaster

Alignment Length:	162	Identity:	45/162 - (27%)
Similarity:	73/162 - (45%)	Gaps:	18/162 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   439 CSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLF-MICWMIYGCIS 502
            |..|....|.||.||..|..||.|.||||.:.|.|:|..|||:|||::|:|.. .:..::|..|.
  Fly    93 CGECQKLAPPRSWHCKACKVCILKRDHHCIYTGCCIGLRNHRFFMGFIFYLFVGSVYALVYNSIY 157

Human   503 YWGLHCETTYTKDGFWTYITQIATCSPWM------FWMFLNSVFHFMWV-----AVLLMCQMYQI 556
            .|.:|...      :..::|.:....|.:      ||..:..||:.:.:     .|||:.....|
  Fly   158 MWVIHGHI------YSNWVTVLKLACPMLHLVTGSFWTNMYLVFYSLNILALAYGVLLLAYHVPI 216

Human   557 SCLGITTNERMNARRYKHFKVTTTSIESPFNH 588
            ...|..:.:|....:.|:.:....::.|.|.:
  Fly   217 VLRGGVSADRTKESKEKYDRGVYQNLRSVFGN 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC17	NP_056151.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	11..305
		ANK repeat	89..120	CDD:293786
		Ank_2	94..187	CDD:403870
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:403870
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		Ank_2	229..>286	CDD:423045
		DHHC	438..568	CDD:396215	42/140 (30%)
CG10344	NP_611671.1	zf-DHHC	93..220	CDD:279823	40/132 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810