DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC17 and CG17287

DIOPT Version :9

Sequence 1:	NP_056151.2	Gene:	ZDHHC17 / 23390	HGNCID:	18412	Length:	632	Species:	Homo sapiens
Sequence 2:	NP_611197.1	Gene:	CG17287 / 36939	FlyBaseID:	FBgn0034202	Length:	338	Species:	Drosophila melanogaster

Alignment Length:	310	Identity:	73/310 - (23%)
Similarity:	120/310 - (38%)	Gaps:	78/310 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   310 PFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTW 374
            |.|:|  :||:.      |.....:|       |...|...|:     |.:|:.|   |:.::..
  Fly    20 PALII--LGFLV------WSYHVFVY-------QICIKKVSDY-----LTIGLLL---FFYHLLL 61

Human   375 FFWFWNDLNFLF---IHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAE------- 429
            |.:.|.....:|   :.:|             ..||..|   :..::.|:...:|.|.
  Fly    62 FMFLWTWFRCIFVAPVRIP-------------DQWKISP---EDVDKLKRNDGIEGASRVLNYAA 110

Human   430 ------TGSLD-LSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLF 487
                  |.::| |..:|.||.|.||.|:.||..|:.|:.|.||||||:.|||...|.:||:.:||
  Fly   111 RNLPIATCTIDGLVRYCKTCWIIKPDRAHHCRTCHMCVLKMDHHCPWIVNCVHFHNFKYFILFLF 175

Human   488 ----FLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVL 548
                :..::.|.|:|           ..|...||  .:|.:.....|....:|..:...::..:
  Fly   176 YAEVYCFYLFCVMVY-----------DLYLICGF--EVTALKNQHSWNILQYLVCILFNIFTVI- 226

Human   549 LMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFF 598
                ||.:|.|.::.|.......|..:.:......:.||.|...|..|.:
  Fly   227 ----MYTVSLLNVSRNRTTMESAYATYFLLGGKNNNGFNLGYFVNFRDLY 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC17	NP_056151.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	11..305
		ANK repeat	89..120	CDD:293786
		Ank_2	94..187	CDD:403870
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:403870
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		Ank_2	229..>286	CDD:423045
		DHHC	438..568	CDD:396215	40/133 (30%)
CG17287	NP_611197.1	zf-DHHC	125..243	CDD:279823	40/135 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810