DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC17 and Dnz1

DIOPT Version :9

Sequence 1:	NP_056151.2	Gene:	ZDHHC17 / 23390	HGNCID:	18412	Length:	632	Species:	Homo sapiens
Sequence 2:	NP_477449.1	Gene:	Dnz1 / 34503	FlyBaseID:	FBgn0027453	Length:	276	Species:	Drosophila melanogaster

Alignment Length:	280	Identity:	62/280 - (22%)
Similarity:	107/280 - (38%)	Gaps:	90/280 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   321 ADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFL 385
            ||..:..|:|...|.|.:|.            |.|..|                    :|.:.||
  Fly    23 ADYVVIRWIILTTMPGSLWM------------SFHVVL--------------------FNTVVFL 55

Human   386 FIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLS-------------- 436
            ..    :::|.|:|        ||||.:.....:             ||.|
  Fly    56 LA----MSHSKAVF--------SDPGTVPLPANR-------------LDFSDLHTTNKNNPPPGN 95

Human   437 ------IFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICW 495
                  ..|:.|...:|.|:.||.:|.|||.:.||||||:.||||..|.:||:.:|.::..:..:
  Fly    96 GHSSEWTVCTRCETYRPPRAHHCRICKRCIRRMDHHCPWINNCVGERNQKYFLQFLIYVALLSLY 160

Human   496 MIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQI---- 556
            .|...:..|...||.. :::...|.:..|.:    :..|.::::|. ::|..:::.|::.|
  Fly   161 SIALIVGSWVWPCEEC-SQNVIETQLRMIHS----VILMLVSALFG-LFVTAIMVDQLHAILYDE 219

Human   557 ---SCLGITTNERMNARRYK 573
               ..:......|.|.|:|:
  Fly   220 TAVEAIQQKGTYRPNRRKYQ 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC17	NP_056151.2	Necessary and sufficient for interaction with DNAJC5 and SNAP25. /evidence=ECO:0000250\|UniProtKB:Q80TN5	11..305
		ANK repeat	89..120	CDD:293786
		Ank_2	94..187	CDD:403870
		ANK repeat	122..154	CDD:293786
		ANK repeat	156..187	CDD:293786
		Ank_2	161..255	CDD:403870
		ANK repeat	189..221	CDD:293786
		ANK repeat	224..255	CDD:293786
		Ank_2	229..>286	CDD:423045
		DHHC	438..568	CDD:396215	36/136 (26%)
Dnz1	NP_477449.1	DHHC	97..228	CDD:396215	35/136 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810