Protein Alignment MED13L and med13b

DIOPT Version :10

• Sequence 1: NP_056150.1
• Gene: MED13L / 23389
• HGNCID: 22962
• Length: 2210
• Species: Homo sapiens
• Sequence 2: NP_001077307.2
• Gene: med13b / 564707
• ZFINID: ZDB-GENE-030131-3529
• Length: 2103
• Species: Danio rerio
• Alignment Length: 2279
• Identity: 1139/2279 - (49%)
• Similarity: 1478/2279 - (64%)
• Gaps: 256/2279 - (11%)

Human     7 WVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCV 71
            :|.|||||||||||||.||:||||||:.:.:.| ....||:....::||||.||.|||:|::|.|
Zfish     6 FVPNGASLEDCHSNLFCLADLTGIKWKCFVWQG-PTSSPILFPVTEEDPILCSFSRCLKADVLSV 69

Human    72 WRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMD 136
            |||...|..:|||||||||:||...::||:|...|:|.||:||:||||||||||||||||||||:
Zfish    70 WRRHQTPGRRELWIFWWGDDPNFAELVHHDLSCNEDGSWESGLTYECRTLLFKAIHNLLERCLMN 134

Human   137 KNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQ 201
            ::|||||||||:||||||||:||||||||:||||:||:|||||||||.||||:||::|||:.:||
Zfish   135 RSFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFVHGDSNVCTSVEINQHQPVYLLSEEHLTLAQ 199

Human   202 SSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEE-DELGYDDDF 265
            .|.:..||::|||||:||||||::|:|||.|:||||||:.|||:....||.:.:: |:|.::||.
Zfish   200 QSSSSVQVILSPYGLSGTLTGQSFKLSDPPTQKLIEEWKQFYPIGPNTKEVTDDKMDDLDWEDDS 264

Human   266 PVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAG----------GHIAVGQQGLGSVKDPSN 320
            ..||||:|.|||||||::.||::|:|||:..:|:|:.          ..:..|..|:.||
Zfish   265 LAAVEVVVAGVRMVYPASLVLVAQSDIPLVATVSSSSSSGSYAGAPHNQLVHGDTGISSV----- 324

Human   321 CGMPLTPPTSPEQAILGESGGMQ----SAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVW 381
               .||||||||:|........:    ||.|.:.|.|.      |....||||.:|.:.||.|||
Zfish   325 ---TLTPPTSPEEAQAVSQPAQKWVKLSAMSGVFSVDS------SSHHGGKIPRRLASQMVERVW 380

Human   382 KECILNRTQSKR--SQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLK-RCAVGPNRPPT 443
            :||.:||.|:||  |.||....||| ....:.||||:.:||..|||||.|..| |....|..||:
Zfish   381 QECNINRAQNKRKFSTMSNGVCEEE-TDKASVWDFVESSQRSQCSCSRLKNQKQRACSTPGHPPS 444

Human   444 VSQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEEL-CMEQDTPGQK 507
            ..|             ||..|:|||.||:.|||||.|||||.|||||.|:.||. .:||.....:
Zfish   445 AGQ-------------PPQPSTKHKMAEKLEKGDKQQKRPLTPFHHRSSLCEEQPSLEQGESVHR 496

Human   508 LGLAGIDSS-------LEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPI-----SPLPPTLS 560
            |.|.|.:.|       .:|:||:                   .||  .||..     ||.||.||
Zfish   497 LCLQGHEDSRYPSLHHADVTSSK-------------------TPM--LHSSADEMAGSPQPPPLS 540

Human   561 PQP--RGQE-TESLDPPSVPVNPALYGNGLE--LQQLSTLDDRTVLVGQRLPL-----MAEVSET 615
            |.|  |.:| .:.:...|.|::...|....|  |:.....|:.|:   ..|||     ..|..|.
Zfish   541 PHPCERMEEPADGMKSSSSPLHQHFYPPSSEPCLEPQKPPDESTL---DPLPLPCPPPYPETLEA 602

Human   616 ALYCG--IRPSNPESSEKWWHSYRLPPSDDAEFRPPEL-------QGERC---DAKMEVNSESTA 668
            .:|.|  |.| |.:::...|..:|:|...:::|..|.|       .|.|.   |..:.:....::
Zfish   603 TIYVGSAINP-NEDTTHNPWKYFRVPGGRNSDFHTPHLPVVAHFEDGNRTGGQDGIVSITEMMSS 666

Human   669 LQRLLAQPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKC 733
            .:|.|....:..|:::.|:.|     :|......:.|    .:.:|||.||:||.::.| ::|..
Zfish   667 SKRPLKVSEELVKMYEHKKNQ-----YLSSAVCDEDP----EQESDPYAFEEGDEEFNF-SDKDK 721

Human   734 KQGTEKDSLKKNKSEDGFGTK-DVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSL 797
            |.|:|:::.||.|.|||..:. |....|.|.|:|                           ::||
Zfish   722 KSGSEREAGKKAKREDGSSSSDDAQGSGGSKPLP---------------------------TTSL 759

Human   798 TQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYP-PTVADL 861
            ...|||..|::||||:| |||:|:|  ..|   .|:..|.|.|::..||:.:.|.|.| |..|||
Zfish   760 IHETDLVVSINDLDNLF-NSDEDDL--TQP---GSRRAAGGAEEKFGGKEPKPAAPDPLPCCADL 818

Human   862 QRMFPTPPSLEQHPAFSPV-MNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPK 925
            .:||||||||:|  .:||: |.     ::|:...|.:::..|..       .||||||:|..|||
Zfish   819 HQMFPTPPSLDQ--GYSPINMG-----NTESAAGLSLLDGAMSG-------NFKMEVEEGFCSPK 869

Human   926 PEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPA 990
            |.||||||||.|..|.|..:|.|::||||.|||.||||:|:|:.|::||||.: .|:|.|....|
Zfish   870 PSEIKDFSYVFKPESCQVLIGCSLYAPLKTLPSQCLLPVKLPEECVYRPSWTV-GKLEMLQPMAA 933

Human   991 ATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPR 1055
            .||:... :|:|||||..:.:...|||.:.....|| ||.||||||:||||||||.|.|||||||
Zfish   934 MTFLNKD-SNIPSVGSAVEQEQSCTPQTHNTFMSNS-APPSNSGAGILPSPATPRISAPTPRTPR 996

Human  1056 TPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVM 1120
            ||||||  |.||.|||:||:::|..||||||||.|||:||||||:..||||||||||||||:|||
Zfish   997 TPRTPR--GPASVQGSLKYENSDLNSPASTPSTCRPLSSVEPATVPSIPEAHSLYVTLILSESVM 1059

Human  1121 NIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYR----CTCGFSAIMNRKLGYNSGLFLE 1181
            |:|||.||||||||.|||||.|||||:||.|.:.:.||.    |:|||||:|||:.|..:|||||
Zfish  1060 NLFKDCNFDSCCICVCNMNITGADVGVYISDPNMDSQYSSMDPCSCGFSAVMNRRYGNGAGLFLE 1124

Human  1182 DELDIFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLDYI 1246
            |||||.|:.||..:..|:.....::..|.:  ||...::.|..|:||||:..|.||:.:...|.:
Zfish  1125 DELDIMGRGSDAAREIEKHFEAVRAASLKR--GTVLKEQVPDDLMLLLQDLCTNPFSPIIRPDLL 1187

Human  1247 SSNNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSN 1311
            .:..:..          ::.:..||:::|:.|||.|||::||.:||||||.||:|:::|.|...|
Zfish  1188 GTVIKSP----------IRLEERDYYSDCYMALEHGRQFMDNMSGGKVDETLVKSSSLHHWAKRN 1242

Human  1312 VLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEES 1376
            ..|:|||.||||:||||||||.|||.|||||:.|:|    .|||||||||||||||||:||::||
Zfish  1243 AFDMSMLFSQDVLRMLLSLQPVLQDTIQKKRSVRSW----GVQGPLTWQQFHKMAGRGSYGTDES 1303

Human  1377 PEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDL 1441
            |||||||||||||:.|::.:|||:||:||:||||||...|||.|:||||:|||||.|||||||||
Zfish  1304 PEPLPIPTLLVGYEYDYVVLSPFALPYWEKLLLDPYSSQRDVGYMVVCPDNEALLNGAKTFFRDL 1368

Human  1442 SAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPW-SGEENDNHSRLKLYAQV 1505
            :||||.||||||:||.|...|||:.|....::.|||:.:.:|..:.. |...::..::|||||.|
Zfish  1369 TAVYESCRLGQHRPIAKSHADGIVTVSDAGSKALTDQTLIDWLPKTINSSSSSEALNKLKLYAHV 1433

Human  1506 CRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNSSS 1570
            |||.||..||:..||.|||.    |..||::  ..|..::.|:....:..|...|  |..:|:::
Zfish  1434 CRHDLASCLASQSLDGSLLT----QRNPASS--SQTSSSSSPVTTAQNVTPTTNS--NSNTNTNT 1490

Human  1571 TNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGSVGGQNPSTGGISADRTQGNIGCGGD 1635
            |..:.|:|:|.||.|  ....:.|. |:.:|....|..|....|  .:||.||       |..||
Zfish  1491 TPTSTSTSSSSSSCP--QGVGNMPS-SKPNTIPPFGAQGLQSSQ--QSGGQSA-------GTLGD 1543

Human  1636 TDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHA--HPPAVVIYMVDPFTYAAEEDSTSGNF 1698
            .....|..|...:..||..|||::|:||:   .||||  :|||:|||:|:||:|......:|.:.
Zfish  1544 ATSATSQPQVPSEPAESTMEREKVGVPTD---GDSHAVTYPPAIVIYIVNPFSYEENCQGSSSSV 1605

Human  1699 WLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTM-KDEQVFYIQYLKSMAFSVYCQCRRPL 1762
            |.::|:|||.|||..||.|:||:..:||:|.||:||.: .:|:..|.|:|||:|||||.||||.|
Zfish  1606 WTIALLRCYLEMLQLLPPHIRNAVYVQIIPSQYLLQPVWSEERHIYAQHLKSLAFSVYTQCRRRL 1670

Human  1763 PTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLF 1827
            ||..::|:||||||..:|:..|::.|||..:.||:|||:|||:||||||||||||||:|||||||
Zfish  1671 PTSTNVKTLTGFGPGLAIDTALQSKERPQCLHLYAPPFVLAPVKDKQTELGETFGEAAQKYNVLF 1735

Human  1828 VGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSL 1892
            |.||||||||||||||||.:||||||||::|.:|||:||.|.|||:.|||||||||:.:||||||
Zfish  1736 VAYCLSHDQRWLLASCTDQYGELLETCVISIDVPNRARRKKGSARRQGLQKLWEWCLDLVQMTSL 1800

Human  1893 PWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQG 1957
            |||:|||||||:|||||:||||||...:||::.::||::||||||||||||||||.||||||||.
Zfish  1801 PWRIVIGRLGRIGHGELRDWSILLSRRNLQSLGRRLKEMCRMCGISAADSPSILSTCLVAMEPQA 1865

Human  1958 SFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNN 2022
            |||:|||:|:.||||||||.||||:||||||||.|||||||||||:.:|          .||...
Zfish  1866 SFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSAGLQ----------AFSDVT 1920

Human  2023 DDM-----FVDLPFPDDM-DNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQH----SRSQ 2077
            |.|     .:||...:|: |.|    :...:.:||.:|||.||        |||:.|    |:.|
Zfish  1921 DGMGGMDGILDLFAENDLVDPD----LINIIPNSPTTSPVHSP--------GSHYHHGGDGSKGQ 1973

Human  2078 G-ERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQT 2141
            | :|:.|.:....:.|||:|||||||||||..||.|||||||||:||||||||||||.::|..|:
Zfish  1974 GTDRMESHDESPNILQQPMALGYFVSTAKAGPLPDWFWSSCPQAKNQCPLFLKASLHLNVSSVQS 2038

Human  2142 DELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAI 2206
            ||||.:::|    |||||..||||||||||||||||||||:||||||.||||||||||.|:||.|
Zfish  2039 DELLHSKHS----HPLDSSHTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPVHFVVLNQMYNFI 2099

Human  2207 MNIL 2210
            ||:|
Zfish  2100 MNML 2103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED13L	NP_056150.1	Med13_N	13..>222	CDD:463303	139/208 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..414		9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	435..489		24/53 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..582		19/70 (27%)
		LXXLL motif 1	669..673		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..770		13/34 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1016..1096		55/79 (70%)
		LXXLL motif 2	1225..1229		2/3 (67%)
		Leucine-zipper	1380..1401		14/20 (70%)
		MID_MedPIWI	1416..1760	CDD:465699	149/347 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1530..1656		33/125 (26%)
		Med13_C	1796..2199	CDD:461879	274/413 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2045..2080		14/39 (36%)
med13b	NP_001077307.2	Med13_N	12..>220	CDD:463303	139/208 (67%)
		MID_MedPIWI	1343..1668	CDD:465699	149/347 (43%)
		Med13_C	1704..2092	CDD:461879	274/413 (66%)