Protein Alignment MED13L and med13a

DIOPT Version :10

• Sequence 1: NP_056150.1
• Gene: MED13L / 23389
• HGNCID: 22962
• Length: 2210
• Species: Homo sapiens
• Sequence 2: NP_001268397.2
• Gene: med13a / 100004024
• ZFINID: ZDB-GENE-070627-13
• Length: 2157
• Species: Danio rerio
• Alignment Length: 2287
• Identity: 1190/2287 - (52%)
• Similarity: 1522/2287 - (66%)
• Gaps: 211/2287 - (9%)

Human     4 AANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAP-----AQDDPILLSFIRC 63
            :|.:|.|||||||||||||.||:||||||:||.:.|.      ||||     .::||||.||.||
Zfish     2 SACFVPNGASLEDCHSNLFYLADLTGIKWKRYVWQGP------ISAPMLFPVTEEDPILCSFSRC 60

Human    64 LQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHN 128
            |::::|.||||..:...:|||:|||||:||...:|||||...::|:||:||||||||||||||||
Zfish    61 LKSDVLSVWRRSQRQGRRELWLFWWGDDPNFADLIHHELTAEDDGVWESGLSYECRTLLFKAIHN 125

Human   129 LLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLIN 193
            |||||||:::|||||||||:||||||||:||.|||||:|||||||:|||||||||.||||:|.::
Zfish   126 LLERCLMNRSFVRIGKWFVKPYEKDEKPINKREHLSCSFTFFLHGDSNVCTSVEINQHQPVYHLS 190

Human   194 EEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEE-D 257
            |:|:.:||.:.:||||::||:|||||||||::|:|||.|:||||||..|||:....||.:::: :
Zfish   191 EDHLTLAQQASSPFQVILSPFGLNGTLTGQSFKLSDPPTQKLIEEWNQFYPISPTSKESAEDKME 255

Human   258 ELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAV----GQQGLGSVKDP 318
            ::.::||...||||:|||||||||:..||:.|:|||......|:  |...    |.|...|.:||
Zfish   256 DIDWEDDSLAAVEVLVGGVRMVYPACLVLVPQSDIPTITQTGSS--HCTAVYSNGHQVPASNRDP 318

Human   319 SNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMI--TMHSPKRSGKIPPKLHNHMVHRVW 381
            :...:.||||||||:|....|...|......|:.||..:  |.|   ..||||.::.:.:|..||
Zfish   319 AISSVTLTPPTSPEEAQTVHSHSAQKWMRLPVAMDGFSVDNTSH---HGGKIPRRMASQVVETVW 380

Human   382 KECILNRTQSKR---SQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLK-RCAVGPNRPP 442
            :||.:||.|:||   :..|..|.|||.......|||||.|||.:|:|||||.|| |.:..|.:||
Zfish   381 QECNINRAQNKRKFSATASNGTSEEETLIKVGAWDFVDSTQRSNCNCSRHKTLKQRASSTPGQPP 445

Human   443 TVSQPGFSAGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQD-TPGQ 506
            |..|          :..||   .|||..|:.|||||.||||..|||||.||.|::.||.| :.||
Zfish   446 TAGQ----------TQQPP---IKHKAGEKPEKGDKQQKRPQTPFHHRNSVCEDVTMETDASAGQ 497

Human   507 KLGLAGIDSS-------LEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQP- 563
            :|.|.|.:|.       .:|.:..|      .|..::.....:..........||.||.|||.|
Zfish   498 RLALRGQESGRFPGLRPTDVGTGSK------PPQLHSGAGSTVGSSGPTEMVGSPQPPPLSPHPC 556

Human   564 -RGQE-TESLDPPSVP-------VNPALYGNGLELQQLSTLDDRTVLVGQRL-PLMAEVSETALY 618
             ||:| ::::..||.|       ..|.|      |.|....|.|...:.|.. |...|..|...|
Zfish   557 ERGEEPSDTIKNPSTPQHFYPPSTEPCL------LPQKGPDDARLEPLTQPFPPAYPETLEPTPY 615

Human   619 CGIRPS-NPESSEKWWHSYRLPPSDDAEFRPPELQGER--------CDAKMEVNSESTALQRLLA 674
            .....: :.:.|...|..:.||...||||..|.|.|::        .:..|.|.....|.:|||.
Zfish   616 ISAAVNMDDDGSHAPWRFFNLPRRKDAEFPTPTLPGDKLREEASLGAEGIMSVTESMAASKRLLK 680

Human   675 QPNKRFKIWQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEK 739
            ..::|.:::..:|.|    |    |..:...||...|| |||.|.|||:|:.| ::||.|.|.|:
Zfish   681 VSDERIQMYLQRQNQ----H----LAAAITDGDHEPEV-DPYAFVDGDVKFTF-SDKKDKAGLER 735

Human   740 DSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLA 804
            :..||:|.|||                          :|...|.::..|..||.|:||...:|||
Zfish   736 EPGKKHKGEDG--------------------------NAASDDAQRAAAHNRAASTSLIHDSDLA 774

Human   805 PSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLG-KDGRAAVPYPP---TVADLQRMF 865
            .|:.||||:| |||:||   .:|..|.    ||...|...| |:.:.|...|.   :.|||.:||
Zfish   775 VSIKDLDNLF-NSDEDE---QTPGARR----AVNGADEKFGSKETKPATLDPVSCISTADLHQMF 831

Human   866 PTPPSLEQH-PAFSPV-MNYKDGISSETVTALGMMESPMVSMVSTQL-TEFKMEVEDGLGSPKPE 927
            ||||||||| ..:||: |..||| ..|..:.|..::.|      |.| ..||:|||:...||||.
Zfish   832 PTPPSLEQHFMGYSPMNMGSKDG-CMEPGSGLNALDGP------TALGGPFKIEVEESFCSPKPS 889

Human   928 EIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAAT 992
            ||||||:|:|....|||||.|||||||.|||.||.|:|:||.|::||||.: .|:|.|...||.|
Zfish   890 EIKDFSFVYKPELCQPFVGCSMFAPLKSLPSQCLPPIKLPDECVYRPSWTV-GKLELLNSVPAMT 953

Human   993 -FIRDGYNNVPSVGSLADPDYLN--TPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTP 1054
             |.:||.||.      .:.||:.  |||.:||. |:::||.||||..:||||||||||.||||||
Zfish   954 IFSKDGENNA------MEQDYIQTYTPQTHTPF-LSNSAPPSNSGTSILPSPATPRFSAPTPRTP 1011

Human  1055 RTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSV 1119
            |||||||  |.||.|||:||:::|..||||||||.||||||||||:..|||||||||.||||:||
Zfish  1012 RTPRTPR--GPASVQGSLKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESV 1074

Human  1120 MNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDEL 1184
            ||:|||.||||||||.|||||||||||:||.|.:.|.||.|.|||||::||:.|..|||||||||
Zfish  1075 MNLFKDCNFDSCCICVCNMNIKGADVGIYINDPNMEAQYPCGCGFSAVVNRRYGNGSGLFLEDEL 1139

Human  1185 DIFGKNSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLD--YIS 1247
            ||.|:.||:.|.||:|....:...|.:..|..|.:.|. .|:.|||:|.|.||:.:..||  .:|
Zfish  1140 DIIGRGSDVSQEAEKRFEALRCISLEKTGGGGKDRVPD-ELISLLQDQCTNPFSPILALDPEGLS 1203

Human  1248 S---NNRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPH 1309
            |   ......||       |:.:..|:..:|:.|||.|||::||.:||||||.||:|..:|.|..
Zfish  1204 SQGPGGTTVPPC-------VRVEERDFHNDCYLALEHGRQFMDNMSGGKVDEVLVKSTCLHHWAK 1261

Human  1310 SNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSE 1374
            .:.:|:|.|.||||:|:||||||.||||||||||.|:|    .|||||||||||||||||:||::
Zfish  1262 RSAVDVSALCSQDVLRVLLSLQPVLQDAIQKKRTVRSW----GVQGPLTWQQFHKMAGRGSYGTD 1322

Human  1375 ESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFR 1439
            ||||||||||.||||:.||:.:|||.||:||:|||||:|..|||.|:|:||::::||.|||:|||
Zfish  1323 ESPEPLPIPTFLVGYEYDFVVLSPFGLPYWEKLLLDPFGSQRDVGYLVLCPDSDSLLTGAKSFFR 1387

Human  1440 DLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEENDNHSRLKLYAQ 1504
            :|:||||.|:||||:||.||..|||:|||...|:||:::.|::||.:..|| .:|..::|||:||
Zfish  1388 ELTAVYESCKLGQHRPISKVHADGIVRVGGAAAKKLSEQPVNDWFLKAASG-SSDAFAKLKLFAQ 1451

Human  1505 VCRHHLAPYLATLQLDSSLLIPPKYQTP-PAAAQGQATPGNAGPLAPNGSAAPPAGSAFNPTSNS 1568
            ||||.|||||||..|||||||.|   || |::.|..::..:....:.:.::....|||.|..:||
Zfish  1452 VCRHDLAPYLATQPLDSSLLIQP---TPVPSSTQSSSSQSSGSASSNSQTSMASGGSALNNNNNS 1513

Human  1569 SSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFS--GSVG--GQNPSTGGISADRTQGN 1629
            :::|..:....|.::.|  |||:|.|..|.|.:...|.|.  ||:|  |.:..:|.:.......|
Zfish  1514 AASNSGSGLPGSTNNTP--SSSSSGPQGSSIQSAKPSSFPPFGSMGVQGNSSQSGALGQQAVTQN 1576

Human  1630 IGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHA--HPPAVVIYMVDPFTY-AAEE 1691
            ....||.....|.:|...:..||..|||::|:||:   .||||  :|||::||:||||:| .||.
Zfish  1577 SSLSGDNSAINSQTQGPSEPPESTMEREKVGVPTD---GDSHAITYPPAIMIYIVDPFSYEEAEP 1638

Human  1692 DSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMK-DEQVFYIQYLKSMAFSVY 1755
            .|:..:.|.|.|:|||.|||..||.|:|||..:|||||||:||.:: :|:..|.|:|||:||||:
Zfish  1639 GSSQSSKWTLGLLRCYLEMLQALPTHIRNSVFVQIVPCQYLLQPVRSEERHLYAQHLKSLAFSVF 1703

Human  1756 CQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEAS 1820
            .||||||||..::||||||||..:::.:|:||:||..::||:|||||||.|||||||||||||||
Zfish  1704 TQCRRPLPTSTNVKSLTGFGPGLALDTSLRNPDRPECLRLYTPPFILAPTKDKQTELGETFGEAS 1768

Human  1821 QKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIG 1885
            |||||||||||||||||||||:||||:|||||||::::.:|||:||.|.||||:|||||||||:|
Zfish  1769 QKYNVLFVGYCLSHDQRWLLATCTDLYGELLETCIISVDVPNRARRKKGSARKMGLQKLWEWCLG 1833

Human  1886 IVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACL 1950
            :|||||||||||||||||:|||||:||||||...:||::|::||:.|::|||||:|:||||||||
Zfish  1834 LVQMTSLPWRVVIGRLGRIGHGELRDWSILLSRRNLQSVSRRLKENCKLCGISASDTPSILSACL 1898

Human  1951 VAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNE 2015
            ||||||||||:|||:|:.||||||||.||||:|||:||||.|||||||||||:.:||..:||.:|
Zfish  1899 VAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSAFVQVNSSNYTHE 1963

Human  2016 D---GFSPNND------DMFVDLPFPDDM-DNDIGILMTGNLHSSPNSSPVPSPGS--PSGIGVG 2068
            :   .|:|.||      .:|..|...:|: |.||    ...|.:||.:|||.||||  |.| |.|
Zfish  1964 NIDIAFNPGNDGSDPMGGIFDLLEQENDLVDPDI----INILPASPTTSPVHSPGSQYPHG-GDG 2023

Human  2069 SHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLH 2133
            |..|.:    :|:.|.|....:.|||||||||||||||..||.||||:|||||||||||||||||
Zfish  2024 SKGQST----DRMESHEEAPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLH 2084

Human  2134 HHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVV 2198
            .|:|..|:||||.:::|    |||||..||||||||||||||||||||:||||||.||||:||||
Zfish  2085 LHVSSVQSDELLHSKHS----HPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVV 2145

Human  2199 LTQLYNAIMNIL 2210
            |.|:||.||.:|
Zfish  2146 LNQMYNFIMTML 2157

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED13L	NP_056150.1	Med13_N	13..>222	CDD:463303	141/213 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..414		8/25 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	435..489		22/53 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..582		18/72 (25%)
		LXXLL motif 1	669..673		1/3 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	736..770		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1016..1096		56/79 (71%)
		LXXLL motif 2	1225..1229		1/3 (33%)
		Leucine-zipper	1380..1401		14/20 (70%)
		MID_MedPIWI	1416..1760	CDD:465699	161/352 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1530..1656		34/130 (26%)
		Med13_C	1796..2199	CDD:461879	285/414 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2045..2080		16/36 (44%)
med13a	NP_001268397.2	None