Protein Alignment SIK3 and par-1

DIOPT Version :9

• Sequence 1: NP_001353615.1
• Gene: SIK3 / 23387
• HGNCID: 29165
• Length: 1369
• Species: Homo sapiens
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 1107
• Identity: 329/1107 - (29%)
• Similarity: 466/1107 - (42%)
• Gaps: 288/1107 - (26%)

Human     6 ASGAGGAAGAGTGGAGPA------------------------------GRLLPP----------- 29
            ||||....|.|:...|||                              |..|..
  Fly   125 ASGAAATGGVGSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTTDGARLSSNNSAVVASSAI 189

Human    30 -----PAPGSPAAPAA------------------VSPAAGQP----RPPAPASRGPMPARIGYYE 67
                 ..|||..||..                  .|.|.|.|    |..||.........||.|:
  Fly   190 NHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYK 254

Human    68 IDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVM 132
            :.:||||||||.||.|.||.|..:|||||||||||:..:|:|:||||:|||||.||:|::|:||:
  Fly   255 LIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVI 319

Human   133 ETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD 197
            |||:.:||:.|||||||:||:||.||||.|||||.||:|||:||.:||.:.|:||||||||||||
  Fly   320 ETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLD 384

Human   198 ANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALP 262
            :.||||||||||||.||||..|.|:||||||||||||:||:||||:||:|||||:||.||.|:||
  Fly   385 SELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLP 449

Human   263 FDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGDADPNFD 327
            ||||||:.||.|||.||:||||:|||:||:|:|..|||:|.||.|:|.|...|||.:|..:....
  Fly   450 FDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELK 514

Human   328 RLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHYSAIYSLLCDRHKRHKTL 392
            ..|.....|.:.::::        |:..||.::.:...||....||...|.|            |
  Fly   515 PYIEPKADLADPKRIE--------ALVAMGYNRSEIEASLSQVRYDDVFATY------------L 559

Human   393 RLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDEGEEPSPE 457
            .||...:.|.:         ...::|:::::           ..|...|...|..|...:.|:..
  Fly   560 LLGRKSTDPES---------DGSRSGSSLSL-----------RNISGNDAGANAGSASVQSPTHR 604

Human   458 ALVRYLS------MRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQ 516
            .:.|.:|      .||.:                     .||.|......||.....:..:.|..
  Fly   605 GVHRSISASSTKPSRRAS---------------------SGVGPTNAAATVAAATGAVGAVNPSN 648

Human   517 NLQPTGQL--------EYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSP 573
            |....|..        .:|.|:.:...|::               ....:|.||.  :||...:.
  Fly   649 NYNAAGSAADRASVGSNFKRQNTIDSATIK---------------ENTARLAAQN--QRPASATQ 696

Human   574 LVTMT-------PAVPAVTPVDEESSDGEPDQEAVQRYLANRSKRHTL----AMTNPTAEIPPDL 627
            .:..|       ||.|. |....:.::|..........:..||.  ||    :.|..|..||.:.
  Fly   697 KMLTTADTTLNSPAKPR-TATKYDPTNGNRTVSGTSGIIPRRST--TLYEKTSSTEKTNVIPAET 758

Human   628 ----QRQLGQQPFRSRVWPPHLVPDQHRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLE 688
                :.::......||.:|.: ||.  |||:....|    ..|.:....:| |.:......:|..
  Fly   759 NLFDRLRMASAVKSSRHFPRN-VPS--RSTFHSGQT----RARNNTALEYS-GTSGASGDSSHPG 815

Human   689 KMGNNSSIK-------------------QLQQECEQLQKMYGGQIDERTLEKTQQQHMLYQQEQH 734
            :|...|.:.                   :.....:....:...||.::..|...|.:..|:|.:.
  Fly   816 RMSFFSKLSSRFSKRPTIADEAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRER 880

Human   735 ------------HQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNN 787
                        ..::|.:|:  :|                     :|.||.:          |.
  Fly   881 FVLWCVHGDPNTDSLVQWEIE--VC---------------------KLPRLSL----------NG 912

Human   788 HLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSA----IFQQQPEN-------CSSP--PNV 839
            ..|::.|                .:|..|:.:.||.|    :...|..|       .|.|  |..
  Fly   913 VRFKRIS----------------GTSIGFKNIASRIAFDLKLXLNQTNNEGNAAATASRPTDPTD 961

Human   840 ALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQHRTNLMATLSY 904
            .:|....::|  |...|.::.| :.:|.....:..||..|..| ..|.|..:.|.::|.:.:...
  Fly   962 TMTTTNCRRP--SNDSTSRLSE-LSLLCRSLTSQQGSQRRKKS-RLSTGGSEDQKKSNSLLSAFQ 1022

Human   905 GHRPL-SKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSRGSPSSYSPSTGVGFSPTQAL 968
            .:.|. ||:....|.|...|:|....|.:    .:...||:|.|..:|.....:.||....|...
  Fly  1023 MYSPFSSKENMQSSEEVEDLHVIDTQPGH----SVDVPLFADFSPINPIMEEDAEGVEGGKTSEA 1083

Human   969 KV 970
            ||
  Fly  1084 KV 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	174/251 (69%)
		UBA_SIK3	346..390	CDD:270593	9/43 (21%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	174/251 (69%)
		S_TKc	253..504	CDD:214567	174/250 (70%)
		UBA_MARK_Par1	525..563	CDD:270522	11/57 (19%)
		MARK1-3_C	839..936	CDD:213381	20/145 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5061
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840