DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SPECC1L and CG13366

DIOPT Version :9

Sequence 1:	NP_001138940.4	Gene:	SPECC1L / 23384	HGNCID:	29022	Length:	1117	Species:	Homo sapiens
Sequence 2:	NP_001036254.1	Gene:	CG13366 / 31004	FlyBaseID:	FBgn0025633	Length:	1094	Species:	Drosophila melanogaster

Alignment Length:	1234	Identity:	356/1234 - (28%)
Similarity:	573/1234 - (46%)	Gaps:	305/1234 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    13 KVSAISKTQTAEKIKPENSSSASTGGKLVKPGTAASLSKTKSSDDLLAGMAGGVTVTN------- 70
            |..:.:...||.:.:.::|.:|:|........||   |..:..|   .|..|.:.:||
  Fly    37 KSQSSTSLNTAHEQQQQHSITAATTKFYAHQETA---SYERGVD---VGDEGALLLTNQQQEQRR 95

Human    71 -------------------GVKGKK--STCPSAAPSASA--------PAMTTVENKSKISTGTAS 106
                               .:||:|  ...|...|.::|        |.||::           :
  Fly    96 QQQQLLQQPQSNTLPQKKSKLKGQKQPKLLPVQQPHSNAPEPHDPQQPLMTSL-----------A 149

Human   107 STKRSTSTGNKESSSTRERLRERTRLNQSKKLPSAGQGANDMALA-------KRSRSRTATECDV 164
            :..::::||:..:|:          :|.:..|.:...|....|.|       ..:.:.|||....
  Fly   150 AVPQASATGSSSNSN----------INNNNALAALQDGGAAAAAAADFYQQLAAAATATATATSA 204

Human   165 RMSKSKSDNQISDRAALEAKVKDLLTLAKT---------------KDVEILHLRNELRDMRAQLG 214
            ..|.:.:|:.:|...|..|.|......|.:               :..::|...|:::::..|:
  Fly   205 NGSNTSADSPVSSFPAAAAAVAVAAVAASSYQQQQQQQQLLNNEQQQQQLLEANNKMQELHKQM- 268

Human   215 INEDHSEGDEKSEKET----IMAHQP--TDVESTLLQLQEQNTAIREELNQLKNENRMLKDRLNA 273
                .....|:.:.||    ::.:|.  ..::..|:::|......:.|:..||.||..|::||..
  Fly   269 ----ERFRSEQMQLETRITELLPYQSEVAKLKGDLVKMQSLQEKSQMEIGNLKYENESLRNRLRD 329

Human   274 LGFSLEQRLDNSEKLFGYQSLSPEITPGNQSDGGGTLTSSVEGSAPGSVEDLLSQDENTLMDHQH 338
            :   :...|.::||   :|.:..              :..:..|||.|:
  Fly   330 V---VNSPLSDAEK---HQIIQD--------------SQRLHSSAPASI---------------- 358

Human   339 SNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSI--ERSRKGSSGNASEVSVACLTERIH 401
                            .|.|:.||.|        |.|.:  :..::.||   ||:|||||.::|.
  Fly   359 ----------------ALPSTHDAHD--------GTPCLTPDWDKQSSS---SEISVACLQDKII 396

Human   402 QMEENQHSTSEELQATLQELADLQQITQELNSENERLGEEKVILMESLCQQSDKLEHFSRQIEYF 466
            ||||..:||:||||||||||||||....:..:|||||.|||.:|.:|||:|::||.....||...
  Fly   397 QMEETHYSTNEELQATLQELADLQTQLTDTQTENERLAEEKDVLFQSLCRQTEKLNESRTQISTL 461

Human   467 RSLLDEHHISYVIDEDVKSG----RYMELEQRYMDLAENARFEREQLLGVQQHLSNTLKMAEQDN 527
            :.||         ..|.|..    ...|.||:.:||.:.::.|||.:|..|:.|.  .::||.
  Fly   462 QELL---------LRDTKQPAPEVSASEREQKLLDLIKTSQEEREAVLLKQEELG--AELAEM-- 513

Human   528 KEAQEMIGALKERSHHMERI--IESE--------QKGKAALAATLEEYKATVASDQIEMNRLKAQ 582
            |:|:| .|.| |.....|||  ::|:        ::|:|..:..:||    ::...||::||...
  Fly   514 KQARE-AGQL-ELQRQRERIALLDSQLDAANAERRQGEAQFSQAMEE----ISQRAIEISRLSTL 572

Human   583 LENEKQKVAELYSIHNSGDKSDIQDLLESVRLDKEKAETLASSLQEDLAHTRNDANRLQDAIAKV 647
            |||.:.|:.||.:..:.|||:|:.::|:..|.:|:..|...:.||:..:.::.:..||:|.::.:
  Fly   573 LENARSKIEELEADLSRGDKTDLSEVLDVARKEKDALEERVAELQDQCSRSQAELRRLRDQLSGL 637

Human   648 EDEYRAFQEEAKKQIEDLNMTLEKLRSDLDEKETERSDMKETIFELEDEVEQHRAVKLHDNLIIS 712
            .:|.:..:..||..:..|...||:|:.|.|:...|...::|.:.||:.:.:.|:..|       :
  Fly   638 TEECKVVKNNAKCAVSHLEYRLEQLQRDKDKIAGEWQALEERVAELQVQCKCHQEDK-------A 695

Human   713 DLENTVKKLQDQKHDMEREIKTLHRRL-------REESAEWRQFQADLQTAVVIANDIKSEA--- 767
            .|::.:.:.|....|::.::.....||       |:|:.||:||||||...|.:|||.|:||
  Fly   696 QLQSLLAETQRHLGDVQLKLGEAECRLDQETQLRRKEAEEWQQFQADLLMTVRVANDFKTEALSA 760

Human   768 -QEEIGDLKRRLHEAQEKNEKLTKELEEI-KSRKQEEERGRVYNYMNAVER--DLAALRQGMGLS 828
             ::.:.|.|.:    :||...|.::||:: |.:.|:.|..:  :.::.|:|  ::|..|..:..|
  Fly   761 REQLVLDNKTQ----KEKIRLLEQQLEKLTKQQMQQSETPQ--SVLSTVQREMEMATRRSKLSFS 819

Human   829 RRSSTSSEPTPTVKTLIKSFDSASQVPNPAAAAIPRTPLSPSPMKTPPAAAVSPMQRHSISGPIS 893
            |:.|..|     |||||:|.::     |.|.....                      .|.|...|
  Fly   820 RQDSRLS-----VKTLIESIEN-----NKAQGKAD----------------------ESESHYSS 852

Human   894 TSKPLTALSDKRPNYGEIPVQEHLLRTSSASRPASLPRVPAMESAKTLSVSRRSSEEVKRDISAQ 958
            ||    :|:...|:.|..|:    :...|:....|: |:|.::|. .|.|:      |..::.|.
  Fly   853 TS----SLNSGTPDLGTTPI----IFPPSSDWHESI-RLPVLQST-NLHVN------VGNEVGAG 901

Human   959 EGASPAS--------------------LMAMGTTSPQLSLSSSPTASVTPT-------------- 989
            :|.:.:|                    .:|:.:|..|:...|.|:...||:
  Fly   902 QGTNTSSGSGGDLASTTKATLPLRDQQQLAITSTQSQVQNVSQPSTPATPSSAGSSSSGGLPFGN 966

Human   990 -TRSRIREERKDPLSALAREYGGSKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTY 1053
             ::|.|..||||||:.||:. |||||||||||||.||.||:|||||||||||||||||||:||:|
  Fly   967 VSKSFISGERKDPLNMLAKN-GGSKRNALLKWCQNKTVGYRNIDITNFSSSWNDGLAFCAILHSY 1030

Human  1054 LPAHIPYQELNSQDKRRNFMLAFQAAESVGIKSTLDINEMVRTERPDWQNVMLYVTAIYKYFET 1117
            ||..|||.:|...:|||||.|||.|||||||.:||:||:|.:.|||||..||.||||:||||||
  Fly  1031 LPDRIPYDQLTPANKRRNFSLAFAAAESVGIGTTLNINDMCQIERPDWMQVMSYVTAVYKYFET 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPECC1L	NP_001138940.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..176		36/205 (18%)
		DUF3584	<176..>803	CDD:403375	184/675 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..323		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..390		8/33 (24%)
		Smc	<500..801	CDD:224117	90/322 (28%)
		PHA03247	<827..992	CDD:223021	39/199 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..997		20/111 (18%)
		CH_CYTS	1005..1116	CDD:409048	81/110 (74%)
CG13366	NP_001036254.1	Ead_Ea22	554..684	CDD:290646	37/133 (28%)
CG13366	NP_001036254.1	CH	992..1092	CDD:237981	73/99 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148164
Domainoid	1	1.000	231	1.000	Domainoid score	I2440
eggNOG	1	0.900	-	-		E2759_KOG4678
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1953
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45969
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002287
OrthoInspector	1	1.000	-	-		otm41982
orthoMCL	1	0.900	-	-		OOG6_104624
Panther	1	1.100	-	-	O	PTHR23167
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5864
SonicParanoid	1	1.000	-	-		X1969
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790