DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AHCYL2 and AhcyL2

DIOPT Version :9

Sequence 1:	NP_056143.1	Gene:	AHCYL2 / 23382	HGNCID:	22204	Length:	611	Species:	Homo sapiens
Sequence 2:	NP_996221.1	Gene:	AhcyL2 / 42043	FlyBaseID:	FBgn0015011	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	344/501 - (68%)
Similarity:	411/501 - (82%)	Gaps:	12/501 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   112 VTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSL-SRSISQSSTDSYSSAASYTDSSDDE-TSPRD 174
            :.:.|.|....:..||:        |.:.:.|: :|..|..||.|:||.. :|.|||:| .||:|
  Fly     1 MAKMPETTFADLSLADK--------TAVKKSSIEARRFSDVSTCSFSSTC-FTGSSDEEDVSPKD 56

Human   175 KQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQT 239
            ..|:||.|.:|||||:|.::.||||||||||.|||.:|.|||||:.||||.||.||||||:.||:
  Fly    57 NHQRNSAGGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQS 121

Human   240 AVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQP 304
            |||:|||..|||..||||||||||.|.|||||||:|.|:|||:||:|::||||:||.:..:||||
  Fly   122 AVLIETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYSDGWQP 186

Human   305 NMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFD 369
            |:|||||||.||.:.||||:.||.|:||||||||||||||.|||.|||.|||:||||||||.|||
  Fly   187 NLILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAINVNDSVTKNKFD 251

Human   370 NLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMD 434
            ..|.||:||||.||||||:||||||||:||||:|||||..:||..|.||||||:||||||||.||
  Fly   252 TFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCIVYVTEVDPICALQAAMD 316

Human   435 GFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWER 499
            |||:|:||||||.||:|:|.||||||:||:|::||||.||:||||||.:||||..|.||||||||
  Fly   317 GFRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCNMGHSCSEIDVNGLHTPELTWER 381

Human   500 VRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYL 564
            |||||||:.||||:.|:|||||||:||||||:.:||:|:.::|||||||||::|| ||||.||||
  Fly   382 VRSQVDHIRWPDGRMIILLAEGRLVNLSCSTISSFVVSVASSTQALALIELFSAP-GRYKSDVYL 445

Human   565 LPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYR 610
            ||||||||||||||.|||||||||||||:|::||||.||||.||||
  Fly   446 LPKKMDEYVASLHLATFDAHLTELTDEQSKFMGLNKAGPFKANYYR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AHCYL2	NP_056143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..184		25/73 (34%)
		LISN domain, inhibits interaction with ITPR1. /evidence=ECO:0000269\|PubMed:19220705	2..109
		AdoHcyase	185..610	CDD:310083	317/424 (75%)
AhcyL2	NP_996221.1	PRK05476	63..486	CDD:235488	314/423 (74%)
AhcyL2	NP_996221.1	AdoHcyase	67..491	CDD:283003	317/424 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147785
Domainoid	1	1.000	282	1.000	Domainoid score	I1661
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69337
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D207688at33208
OrthoFinder	1	1.000	-	-		FOG0003070
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104147
Panther	1	1.100	-	-	O	PTHR23420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.710