Protein Alignment AHCYL2 and AhcyL1

DIOPT Version :10

• Sequence 1: XP_047276043.1
• Gene: AHCYL2 / 23382
• HGNCID: 22204
• Length: 632
• Species: Homo sapiens
• Sequence 2: NP_647746.1
• Gene: AhcyL1 / 38342
• FlyBaseID: FBgn0035371
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 596
• Identity: 393/596 - (65%)
• Similarity: 441/596 - (73%)
• Gaps: 92/596 - (15%)

Human    43 PPAGGGDPE---APAPAAERPPVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEA 104
            |..||||.:   .|||......||.|.:             .|:||:|::      .|:|
  Fly    12 PGFGGGDKQQQAGPAPQDASVVVPPPAT-------------KQSSALKKT------SRYR----- 52

Human   105 LVSPDGTVTEAPRTVKKFPRSGTGATGNRIQKPEAQYHTIQFADQKQEFNKRPTKIGRRSLSRSI 169
                                                                         |||:
  Fly    53 -------------------------------------------------------------SRSL 56

Human   170 SQSSTDSYSSAASYTDSSD--DETSPRDKQQKNSKGSSDFCVKNI-KQAEFGRREIEIAEQEMPA 231
            |.|||||:|| ||||.||:  |:..||:|.||||||||||||:|| .|..||||||||||||||.
  Fly    57 SASSTDSFSS-ASYTGSSEDGDDVPPREKVQKNSKGSSDFCVRNIGAQHAFGRREIEIAEQEMPG 120

Human   232 LMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESG 296
            ::||:|||..:|||..|||||||||.||||||:|||..|||..||||||||||.|||||||||||
  Fly   121 IIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVRWAACNIYSTQNEVAAALAESG 185

Human   297 FPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGV 361
            .|:|||:||:|:|||||||||||.|.||||||||||||.||.:.||||.|||.:|||||||||||
  Fly   186 IPIFAWRGETEEDFWWCIDRCVNAENWQPNMILDDGGDATHLMLKKYPTMFKLVKGIVEESVTGV 250

Human   362 HRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGK 426
            ||||||||||||.||||||||||||.||||||.|:|||||.|||:||:|||||||||||||:|||
  Fly   251 HRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLYSCKESILDSLKRSTDVMFGGKQVVVCGYGDVGK 315

Human   427 GCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMK 491
            ||..|||..|.|||:|||||||||||.|||||:||||||||.||||:|.|||||||.|||:|:||
  Fly   316 GCAQALKGQGCIVYITEIDPICALQASMDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMK 380

Human   492 NSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFV 556
            :.|||||||||||||||..||||:||||:|||||||:|||:||.|:|||||||:|||||::|:|.
  Fly   381 SGCIVCNMGHSNTEIDVNGLRTPDLTWEKVRSQVDHIIWPEGKYIILLAEGRLVNLSCSSIPSFA 445

Human   557 LSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNK 621
            :|||:.|||||||||:|||.||||.||||||||||||||||||||||||||||:||||||:||||
  Fly   446 VSITSATQALALIELFNAPPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYMGLNK 510

Human   622 NGPFKPNYYRY 632
            .||||||||||
  Fly   511 AGPFKPNYYRY 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AHCYL2	XP_047276043.1	AdoHcyase	208..631	CDD:214963	342/423 (81%)
AhcyL1	NP_647746.1	AdoHcyase	96..520	CDD:214963	342/423 (81%)