DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AHCYL2 and Ahcy

DIOPT Version :9

Sequence 1:	NP_056143.1	Gene:	AHCYL2 / 23382	HGNCID:	22204	Length:	611	Species:	Homo sapiens
Sequence 2:	NP_001285268.1	Gene:	Ahcy / 32471	FlyBaseID:	FBgn0014455	Length:	432	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	228/434 - (52%)
Similarity:	305/434 - (70%)	Gaps:	5/434 - (1%)

- Green bases have known domain annotations that are detailed below.

Human   180 SKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLME 244
            ||.|  :.|.:|..||:||:.|.|||.|||.|||.||:....|||.||:|.||.|:|.|||||:|
  Fly     2 SKPS--YKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQTAVLIE 64

Human   245 TLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQP-NMIL 308
            ||..||||.:|::|||:||.:..|||:|.:|.||:|||||:::::.|||::.:.....|| ||||
  Fly    65 TLVELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTLVFPDGQPLNMIL 129

Human   309 DDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYC 373
            |||||||:.:::|:|...|.|||:.||:.||||.||::.|.|:|.|||:||||||||.||||||.
  Fly   130 DDGGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPAINVNDSVTKSKFDNLYG 194

Human   374 CRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRL 438
            ||||::||:||.||:|..||...|.|||:|||||..|||..|..|.|||:|||.||||.|:|:.:
  Fly   195 CRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGGRVIVTEVDPINALQAAMEGYEV 259

Human   439 VKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQ 503
            ..:.|..::..|.:|.||.::::|..||.:|.:..||||:||.:.||||..|.........|:.|
  Fly   260 TTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVCNIGHFDIEIDVDWLNANAKEKVNVKPQ 324

Human   504 VDHVIWPDGKRIVLLAEGRLLNLSCS-TVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPK 567
            ||......||.|:|||||||:||.|: ..|:||:|.:.|.|.||.|||:...: :|...|::|||
  Fly   325 VDRYTMQSGKHIILLAEGRLVNLGCAHGHPSFVMSNSFTNQVLAQIELWTKSD-KYAVGVHVLPK 388

Human   568 KMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY 611
            .:||.||||||......||:||::||.|||:::.|||||::|||
  Fly   389 ILDEEVASLHLEKLGVKLTKLTEKQATYLGVSQTGPFKPDHYRY 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AHCYL2	NP_056143.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..184		2/3 (67%)
		LISN domain, inhibits interaction with ITPR1. /evidence=ECO:0000269\|PubMed:19220705	2..109
		AdoHcyase	185..610	CDD:310083	222/426 (52%)
Ahcy	NP_001285268.1	PRK05476	1..426	CDD:235488	222/426 (52%)
Ahcy	NP_001285268.1	AdoHcyase	6..431	CDD:283003	222/425 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0499
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371693at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820