DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TNS2 and Pten

DIOPT Version :9

Sequence 1:	XP_006719365.1	Gene:	TNS2 / 23371	HGNCID:	19737	Length:	1428	Species:	Homo sapiens
Sequence 2:	NP_001162933.1	Gene:	Pten / 43991	FlyBaseID:	FBgn0026379	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	90/358 - (25%)
Similarity:	169/358 - (47%)	Gaps:	47/358 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   136 ERRWDLDLTYVTERILAAAFPARPD--EQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 197
            |:.:||||||:.:.|:|..:|| ||  |...|..|.::..:|:..|...|.::|| ||:.:|:.:
  Fly    25 EKGYDLDLTYINDNIIAMGYPA-PDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAK 88

Human   198 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKIS 262
            ...:|..:.:.:.:.|.::.:...|..::.||..|..:||.::||..||:.|.::.||:.:|.|.
  Fly    89 FRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIK 153

Human   263 AGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGSIRMNSSPLFLHYVLIPMLPAFEP 327
            ..||:|||....::..:.|..|  .||||||:.|||.|:..|:..:...|.:..:      .|..
  Fly   154 KSADEALAWYDEKRTKDRKGVT--IPSQRRYVQYFSKLVCSSVPYSKVSLNVCEI------RFSE 210

Human   328 GTGFQPFLKIYQSMQLVYTSGVYHIAGPG---------PQQLCISLEPALLLKGDVMVTCYHKGG 383
            .:..|....:..|:.:::.|...: |.|.         .:...::::|::.:.|||.   :....
  Fly   211 SSCVQNLGMVECSISVLHDSATEN-AKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVK---FELTK 271

Human   384 RGTDRTL-------VFRVQFHTC----TIHGPQLTFPKDQLDEAWTD---ERF--PFQASVEFV- 431
            :..|:.:       .|...:..|    |::....|..|.::|:...|   :||  .|:.|:.|.
  Fly   272 KSPDKIICHFWLNTFFVRNYSPCESDGTVNKYIHTLSKSEIDDVHKDSEHKRFSEEFKISIVFEA 336

Human   432 --FSSSPEKIKGSTPRNDPSVSV---DYNTTEP 459
              ||:..:.......||:..::.   ||::..|
  Fly   337 ENFSNDVQAEASEKERNENVLNFERSDYDSLSP 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS2	XP_006719365.1	C1	42..89	CDD:237996
		PTPc_motif	199..319	CDD:214649	36/119 (30%)
		PTEN_C2	307..434	CDD:287393	25/154 (16%)
		SH2_Tensin_like	1155..1268	CDD:198181
		PTB_tensin	1292..1424	CDD:269924
Pten	NP_001162933.1	PTPc	58..167	CDD:304379	31/108 (29%)
Pten	NP_001162933.1	PTEN_C2	196..335	CDD:287393	23/148 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810