DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNS2 and aux

DIOPT Version :9

Sequence 1:	XP_006719365.1	Gene:	TNS2 / 23371	HGNCID:	19737	Length:	1428	Species:	Homo sapiens
Sequence 2:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	169/795 - (21%)
Similarity:	271/795 - (34%)	Gaps:	261/795 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   119 SKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHR-GHLRELAHVLQSKH-RD 181
            :|...|:.:|.:       |.|||::::|.|||....|:...|..:: .::.::...|:|:. ..
  Fly   397 TKVMQTMQQSLA-------RNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQ 454

Human   182 KYLLFNLSEKRHDLTRLNPKVQD------FGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLY 240
            |..::|..::..  .||.|.|:.      :|.|:.|||.|..|.::...|..:|:|||:.||::.
  Fly   455 KLSIYNFGQRTE--PRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQ 517

Human   241 CKGNKG--KLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSG 303
             .|:.|  ....::.|.:.|:.:....:.|:....:::.     ...|:||:.||:.||..:|
  Fly   518 -TGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRH-----TINLRPSEFRYLYYFGDIL-- 574

Human   304 SIRMNSSPLFLHY---VLI-----PMLPAFEPGTGFQPFLKIYQSMQLV------YTSGVYHIAG 354
                ..:||..||   .|:     |:....:...|.:.::::|.:..|:      |.....:.||
  Fly   575 ----RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAG 635

Human   355 PGPQQLCISLEPALLLKGDVMVTCYH--KGGRGTDRTLVFRVQFHTCTIHGPQ--LTFPKDQLDE 415
            ||...|.|:|...    |||.|..:|  ||........:.:.||:|..|..|:  :||....||:
  Fly   636 PGKIVLPINLTAC----GDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDD 696

Human   416 AWTDE----RFPFQASVEFVFSSSPEKIK----GSTPRNDPSV----------SVDYNTTEPAVR 462
            ....|    ||....|:....|.||...|    .:.|:..|:.          .:|...|:|:.|
  Fly   697 LPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTR 761

Human   463 WDSYENFNQHHEDSVDGAQAACRVGGSL-----THTRGPLDGSPYAQVQRPPRQTPPAPSPEPPP 522
                       .....||:.:.||...|     |.|...|                |:|.|||.|
  Fly   762 -----------SSPPPGARKSDRVSSPLVLPDVTETAHEL----------------PSPMPEPSP 799

Human   523 PPMLSVSSDSGHSSTLTTEPAAESPGRPPPTAAERQ---ELDRLLGGCGVASGGRGAGRETAILD 584
            |..|         ..|..:| ::.|...|.|:|:..   ..| |||..|
  Fly   800 PIDL---------LNLNQQP-SDVPAADPLTSAKPSTDASFD-LLGAFG---------------- 837

Human   585 DEEQPTVGGGPHLGVYPGHRPGLSR------------HCSCRQGYREPCGVPNGGYYRPEGTLER 637
            |::...:|..|...:.|  .|.|.:            ..|..||     |||:   .:|.|
  Fly   838 DDDSTGIGSAPIPDILP--PPPLQQPQPKINNDPFDIFGSVDQG-----GVPS---MKPSG---- 888

Human   638 RRLAYGGYEG---------------SPQGYAEASMEKRRLCRSLSEGL----------------- 670
                :..:.|               ||...|.||.:.......|:.||
  Fly   889 ----FPPFVGSLPTFVAQPAATTNPSPTHPARASADPFANIADLATGLNLNFNRSTLSGKSPVNT 949

Human   671 YPYPPEMGKPATGDFGYRAPGYREVVILEDPGLPALYPCPACEEKLALPTAALYGLRLEREAGEG 735
            .|.|.:...|.........|   :...:..|..|...|..:   .:..||.
  Fly   950 SPQPTQFSSPTHKPSPSSQP---QATFMHTPPTPQTLPSTS---SIRTPTQ-------------- 994

Human   736 WASEAGKPLLHPVRPGHPLPLLLPACGHHHAPMPDYSCL---------KPPKAGEE--------- 782
                               |..:||     ...||||.|         :|...|.:
  Fly   995 -------------------PQAVPA-----QSRPDYSRLHFDSQKAAQQPGTGGSKNSDIFADIL 1035

Human   783 GHEGCSY----TMCP 793
            |.:|.|:    ..||
  Fly  1036 GQQGYSFGSKMNQCP 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS2	XP_006719365.1	C1	42..89	CDD:237996
		PTPc_motif	199..319	CDD:214649	33/130 (25%)
		PTEN_C2	307..434	CDD:287393	37/148 (25%)
		SH2_Tensin_like	1155..1268	CDD:198181
		PTB_tensin	1292..1424	CDD:269924
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	34/133 (26%)
		DnaJ	<1110..1150	CDD:197617
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810