DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TNS2 and ptn1

DIOPT Version :9

Sequence 1:	XP_006719365.1	Gene:	TNS2 / 23371	HGNCID:	19737	Length:	1428	Species:	Homo sapiens
Sequence 2:	NP_596312.1	Gene:	ptn1 / 2541101	PomBaseID:	SPBC609.02	Length:	348	Species:	Schizosaccharomyces pombe

Alignment Length:	247	Identity:	61/247 - (24%)
Similarity:	102/247 - (41%)	Gaps:	53/247 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   114 KSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSK 178
            |.|...|    :.|||:.         ||:.|:|.:::|.:.||....:.:|....::...|.::
pombe    13 KGLKQEK----VNRSFAY---------LDMVYITSKVIAMSTPAAGIHKLYRNDELDVFKYLTTQ 64

Human   179 HRDKYLLFNL--SEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYC 241
            .:|.::|.||  .|..:.|....|.|.::|:.:.:.|||..|.:|...|:......|...:|::|
pombe    65 LKDNWILLNLCAEETVYHLELFKPNVINYGFQDHNPPPLLFLWAIVMNMDALFQTQPLLTLVVHC 129

Human   242 KGNKGKLGVIVSAYMHYSKISAG---ADQALATLTMRKFCEDKVATELQPSQRRYISY------- 296
            |..||:.|.::.:|:    ::.|   |.|:|...|.::.......|  ..||.||:.|
pombe   130 KAGKGRTGTVICSYL----VAFGGLTAKQSLELYTEKRMVRGHGLT--ISSQIRYVYYIEILKQF 188

Human   297 ---------------FSGLLSGSIRMNSSPLFLHYVLIPMLPAFEPGTGFQP 333
                           |......:|:.|||       ||..|.||..|....|
pombe   189 PNYLKAVEFNTGTTFFKSFKCLNIKKNSS-------LILSLHAFSKGRNINP 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TNS2	XP_006719365.1	C1	42..89	CDD:237996
		PTPc_motif	199..319	CDD:214649	33/144 (23%)
		PTEN_C2	307..434	CDD:287393	10/27 (37%)
		SH2_Tensin_like	1155..1268	CDD:198181
		PTB_tensin	1292..1424	CDD:269924
ptn1	NP_596312.1	CDC14	15..201	CDD:225297	48/204 (24%)
ptn1	NP_596312.1	PTPc	<78..179	CDD:304379	28/106 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810