back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PPP1R13B and ASPP

DIOPT Version :10

Sequence 1:	XP_011534895.1	Gene:	PPP1R13B / 23368	HGNCID:	14950	Length:	1193	Species:	Homo sapiens
Sequence 2:	NP_788423.1	Gene:	ASPP / 37422	FlyBaseID:	FBgn0034606	Length:	1069	Species:	Drosophila melanogaster

Alignment Length:	1198	Identity:	358/1198 - (29%)
Similarity:	517/1198 - (43%)	Gaps:	344/1198 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   153 SPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVGNPRVELTLSELQDMAARQQQQIENQQQML 217
            |||    :|...|.|.:     :|||.             .||.:||:.||.||||||::|.|:|
  Fly    46 SPT----RGVVVTSEPK-----LNVPS-------------RLTSAELRAMALRQQQQIDSQHQLL 88

Human   218 VAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEI 282
            ..|||||.|||.||.|...:.:|.|:|::|:|||||||:||:::||:|||||..|..|..||.::
  Fly    89 ATKEQRLRFLKSQEVRSAVASAEGERLRRLRERVEAQESKLRRLRALRGQVDLQKTYNVTLSNDL 153

Human   283 ERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKK------------GKLNGFQSYNGKLTGPAAVE 335
            :...|:|.||::|:..|:.:|:.|::|||:|::            |...|.||    |...|:.|
  Fly   154 DSIRALFSEKEKELSLAVAKVEALTRQLEELRRDRRCPVNILTAAGNGVGGQS----LPPQASRE 214

Human   336 LKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRERLYGKK----------- 389
            |::|.:||..||||:.:|:::|..|:|.|.:|..|:...|:||.||:.||..||
  Fly   215 LEKLRRELMYRNQLSLQQDARLHMQREALQQRQAELRSTDQRIYELQTRLQRKKQANTHHQQQQQ 279

Human   390 ---------------------------------IQLNRVNGTSSPQ------------------- 402
                                             .||......::.|
  Fly   280 QQQQHQQQQHQQQHQQTTVQQQQQQQQQLHVQSAQLLAAAAAATAQQQQQHQQHQQQQQQQQQQS 344

Human   403 -SPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSDG-------HSKPRV 459
             |.|...|.|||:...:......           |..:.|:.||.||::.:.       |:..:.
  Fly   345 ASNLGKHGGVAALKQQLLQKQVN-----------QLAAAAAAAAAGRARGNVAAVEPFIHTPQKS 398

Human   460 TSSWTVSDLDVGPNYGSSRPSASPFVNPNDGN-------WPTLKQNS---SSSVKPVQVAGADWK 514
            |.:.|.|.|..|..:      |:...|.|..|       ...|.|||   :.|| ||.||.:..:
  Fly   399 TITSTASYLSGGMKH------AAATANTNQQNQLIQDLTHVKLGQNSGFFAGSV-PVPVASSSCE 456

Human   515 -----------------DPSVEGSVKQGTVSSQPVPFSALGPTEK-------------------- 542
                             :..:....:...:.|....::.:||.::
  Fly   457 SDESKLAKKLLAAPAKTEAELRKQAQTEAMDSTTHIYAEVGPKKRDREAAAAAAAAAAAAAAAAQ 521

Human   543 ----------PGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSL--ERRKEGSLPRPSA 595
                      .......:.||......::|.|       |.....|.|:|  :..::.:......
  Fly   522 AAAEAANQAATAAAASAISPPATANASKIPKS-------TTSSSSSASALISKLNQQATAKESQD 579

Human   596 GLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV--AIRP 658
            ...|:.:...:..|..|.   |.:..||:::|           .:.|.|.....:.|.|  |.:|
  Fly   580 QQQSQAKKNEISVTSETL---SERNTQQQLTV-----------HSMPLGAISKSVALAVSNASKP 630

Human   659 FLADKGSRPQSPRK-----GPQTVNSSSIYSMYLQQATPPK--NYQPAAHSALNKSVKAVYGKPV 716
            ......:....|||     .|.:|:|.|         :.||  .|.|.. :.:..:|.....:|.
  Fly   631 LQVQVSNVAVPPRKPISSVAPNSVSSGS---------SIPKMITYSPKV-NRVAPNVVMTDPRPA 685

Human   717 LPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLP------RPLSP 775
            ||...:..||           |.||.|...:|.......|..| |..||.....      :.|:.
  Fly   686 LPPKPSKMSP-----------TEQPSPVEANTSGSAGGAGSGA-ASASTANKTQTATFGLQSLNI 738

Human   776 TKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGM 840
            ....||...||..:        ::.|...||   .:||.:...|...|.:.:|..||.:
  Fly   739 NDNLPIKAKPLTIR--------KQPLFEQPR---LKSSQSSSNGQQKPPLLQLQNQRKS------ 786

Human   841 EGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPE 905
                  :||..|.                  .|.||...|      :.:|||:::     :.|.:
  Fly   787 ------EPSARQP------------------TENLPDTSP------QHSPSSESS-----ADETD 816

Human   906 ELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKR 970
            .::.|..|....|.:....:...||.|
  Fly   817 RMVAPSITTSQQETSTSATSTTTTVTT-------------------------------------- 843

Human   971 TNLKKPNSERTGH-----GLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHN 1030
            :|:|    ||||:     |.||.|:|||||||||||||.:||::...:|.:||..||||||.|||
  Fly   844 SNIK----ERTGNGKPKLGRRVSFDPLALLLDASLEGELELVKKTAMQVANPSAANDEGITALHN 904

Human  1031 AVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAA 1095
            |:||||..|||||::||.:|||.|||||||||||||||::.:.|.||||||.:||||:||.||.|
  Fly   905 AICAGHIDIVKFLVEFGCDVNAQDSDGWTPLHCAASCNNLSMVKFLVESGACLFASTLSDHETPA 969

Human  1096 DKCEEMEEGYIQCSQFLYGVQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESET 1160
            :||||.|||:..||::||.:|||||:::.|..||::.|||||.||||||..:.|.:||:.|::|.
  Fly   970 EKCEEDEEGFDGCSEYLYSIQEKLGILHNGDVYAVFSYEAQNGDELSFHVNEPLIVLRKGDDAEN 1034

Human  1161 EWWWAR-LGDREGYVPKNLLGLYPRIKP 1187
            |||||| ....|||||:||||||||:.|
  Fly  1035 EWWWARNAAGEEGYVPRNLLGLYPRVPP 1062

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.