Protein Alignment LARP1 and Larp4B

DIOPT Version :10

• Sequence 1: NP_291029.2
• Gene: LARP1 / 23367
• HGNCID: 29531
• Length: 1096
• Species: Homo sapiens
• Sequence 2: NP_647793.1
• Gene: Larp4B / 38399
• FlyBaseID: FBgn0035424
• Length: 1531
• Species: Drosophila melanogaster
• Alignment Length: 1132
• Identity: 196/1132 - (17%)
• Similarity: 333/1132 - (29%)
• Gaps: 486/1132 - (42%)

Human    70 QQERESPRPLQ-LPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVNPWTKNALP 133
            ||:::||.|.| |.....||:|.. ..||.....|||.|.:|
  Fly   135 QQQQQSPHPAQHLTYGHQPALSQA-TAGGSGTISGGAVGPSG----------------------- 175

Human   134 PVLTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQPTR 198
               ..|.||...|::    ::..|:.:.:.|:.|....||:|  ....:|   :.||.|:..
  Fly   176 ---VVVEGQDTNEYA----IMNGALGQTQDGTVVCYTTDALN--NTNLVA---LDPQPHQIV--- 225

Human   199 KLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEV 263
                                                                  ||:|:
  Fly   226 ------------------------------------------------------VPVQV------ 230

Human   264 PREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSD 328
                    |.:.|.|..:|||     ||..                  |:...|          :
  Fly   231 --------PVQVPVPVQLPAN-----GSAD------------------PQQGSH----------N 254

Human   329 GAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGVEGPRTPKYMNNITYYFDNVSST 393
            .|||                                       |.|..|
  Fly   255 AAGG---------------------------------------EEPNIP---------------- 264

Human   394 ELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIF 458
                :|:  ||..:..|:|||||.:||..|.:|..:||:|.::||..:|.|:.|:.||.||:||.
  Fly   265 ----LDK--LKQMLATQLEYYFSRENLANDTYLLSQMDSDQYVPIYTVARFNLVRKLTNDINLIT 323

Human   459 AALKDSKVVEIVDEKVRRREEPEKW--PLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGS 521
            ..|::|..|::.|:.:|.|...::.  .|..|.:.:..|..:.|...|..||
  Fly   324 EVLRESPNVQVDDKGLRVRPNRKRCIIILREISNNTPLDDVKALFSNESCPR------------- 375

Human   522 PRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLP 586
                   |...|..:|                 .:|                       ::|
  Fly   376 -------PISCEFAAN-----------------NSW-----------------------YIT--- 390

Human   587 QQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGR-------------------KNTFTAWSDEESD 632
                    ...|:|.|:...:| .||:::..|:                   ||.:...|...::
  Fly   391 --------FESDEDAQKAYKYL-REEVKEFQGKPIMARIKPKSFINRIQAVPKNGYRLTSPPTAN 446

Human   633 YEIDDRDVNKILI---VTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKV---------INDGLFY 685
            . .|........:   ..|.|.|:           :|:.|.::|. |.|         |....||
  Fly   447 V-FDPAGAGGATVSYAAAQQPRYL-----------YTNGAAIAAP-ASVQYSNPVLIPIPQNQFY 498

Human   686 YEQDLWAEKFEP-EYSQIKQEVENFKKV--NMISREQFDTLTPEPPVDPNQEVPP---------- 737
              ..|.|..:.| ..:......:||.::  |:.:.   :.|.|:|......:.||
  Fly   499 --PGLVAGPWPPGTVAATTAHGQNFYELGGNIFTT---NPLPPQPVTAGFAQAPPPTSQAMVTPK 558

Human   738 -------------------------------GPPRFQQVPTDALANKLFG---------APEPST 762
                                           .|||  ..|:   |:.:.|         ||.|..
  Fly   559 PQGGGRYNNNHRGNPNNVGGANSGPRAESRSKPPR--STPS---ASHIQGGNIMPIQITAPIPGG 618

Human   763 IARSLPTTVPESPNYRNTRTPRTPR------TPQLKDSSQ-----------TSRFYPVV---KEG 807
            :...:||.:.:.| .:.....:.|:      ..|...|:|           |:|.||:.   |.|
  Fly   619 MVSVVPTNIVQDP-LQPAPLQQQPQQVIQQIQQQPSSSAQQQQAATVQMNNTTRHYPIKSNWKGG 682

Human   808 --RTLDAKMPRKRKTRH---SSNPPLESHVGWVMDSREHRPRTA----SISSSPSEGTPTVGSYG 863
              :.||........|.|   :....|.:|...:...::.:.:|.    .::||.:...|.|....
  Fly   683 MQKNLDKSYSGGVATHHHYTTQVQALPAHSHHLQAQQQLQGQTQQQHYQLASSSAASAPQVTYVT 747

Human   864 CTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLR--DH 926
            ..|......||..|.::::   ||....:.:::.:.:::::.:.:.||........|..::  :.
  Fly   748 TAPAPQQPGQHQHHLVVQQ---TQPQQQQQQQQVVLQQQQVQVQELQEAGDGVEHSSHAMQQVNR 809

Human   927 FNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLE 991
            .:.........||...:||..::          ....::.|.|      ||...:|..|...||
  Fly   810 SSNMSASSSSSLATSMSKEPLQW----------QNRPRRRRRD------EEGGINYSPGGRVGL- 857

Human   992 KFWAFLKYSKAKNLDIDPKLQEYL----------------------------GKFRRLEDFRVDP 1028
                   |..:.:   :|..|::|                            ..:..:.|.   |
  Fly   858 -------YGSSPS---NPHPQQHLMSSSTGSNVQSAGGTDGGGASHRGGERQSHYNTIHDV---P 909

Human  1029 PMGEEGN----------HKRHSVVAGG 1045
            |....||          |.:||.:|.|
  Fly   910 PPQHRGNYKGNNYNPHYHAQHSSMASG 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LARP1	NP_291029.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..356		47/286 (16%)
		PHA03247	<2..328	CDD:223021	44/258 (17%)
		Required for interaction with PABPC1. /evidence=ECO:0000269|PubMed:29244122	77..573		90/498 (18%)
		LARP_1	404..476	CDD:153406	29/71 (41%)
		LHP1	<407..576	CDD:227520	41/170 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	511..598		5/86 (6%)
		Required for interaction with RPTOR and for repression of mRNAs with a 5'TOP motif. /evidence=ECO:0000269|PubMed:29244122	574..1096		102/625 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..861		25/130 (19%)
		Interaction with mRNA. /evidence=ECO:0000269|PubMed:20430826, ECO:0000269|PubMed:26206669	873..1023		24/179 (13%)
		DM15	885..925	CDD:128927	5/41 (12%)
		DM15	926..964	CDD:128927	4/37 (11%)
		Interaction with 7-methylguanosine mRNA cap structure. /evidence=ECO:0000269|PubMed:28379136, ECO:0007744|PDB:5V87	956..999		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1026..1096		9/30 (30%)
Larp4B	NP_647793.1	LARP_4_5_like	269..343	CDD:153400	30/73 (41%)
		RRM_LARP4_5_like	348..423	CDD:409864	19/146 (13%)