DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGEF12 and ROM1

DIOPT Version :9

Sequence 1:	NP_056128.1	Gene:	ARHGEF12 / 23365	HGNCID:	14193	Length:	1544	Species:	Homo sapiens
Sequence 2:	NP_011584.2	Gene:	ROM1 / 852961	SGDID:	S000003302	Length:	1155	Species:	Saccharomyces cerevisiae

Alignment Length:	936	Identity:	177/936 - (18%)
Similarity:	343/936 - (36%)	Gaps:	287/936 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   326 KSETIQDTDTQSLVGSP-STRIAPHIIGAEDDDFGTEHE------------------QINGQCSC 371
            ||:|  .|.||...||. .|.|....|..::|:..||.|                  :|...||.
Yeast    22 KSDT--STPTQLFSGSKVQTNINEISITNDEDEDSTEDENKASLKDYTLGHDTGARYRIAPDCSS 84

Human   372 FQSIELLKSRPA-HLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAH 435
            .|    ||:.|. |::..|:.....|.         .|....||.
Yeast    85 HQ----LKASPVLHISTNLNSSPQSFT---------GDQISPTNK-------------------- 116

Human   436 LKVSVPDE-----------MSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQ---- 485
             |:|:.|.           .|:..:||...|:|. :.:|...::.. .......|:.|..|
Yeast   117 -KISINDSTRQDKGNSCTTTSSPSQKRSNVLLPH-VRKHSSPSLLS-FSKNSGSHMGDPNQLSTP 178

Human   486 --KRSMGLTL-------------AESELTKLDAERDKDRLTL----------------EKERTCA 519
              .:|.|.|:             :.|.|..|::.:.::|.:.                ::..:.:
Yeast   179 PTPKSAGHTMELHSSFNGKHSSSSTSSLFALESLKTQNRRSSNSSNHSSQYRRHTNQHQRHHSRS 243

Human   520 EQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLE-HKRGRIGFLPKI----K 579
            :.....:.|:.|.       |.:.:.|..|:.:  :.:|.|:...|. ||  ::|.|.:.    |
Yeast   244 KSSPVSLTEISMI-------KGTPLVYPALLSL--IAIKFKQTIKLSTHK--KMGLLYRDSFTGK 297

Human   580 QSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSA 644
            |::..            ...|:|   ...|:....||:::|.||..|.
Yeast   298 QAIDT------------LCLIIG---SLDRNLGMLIGKSLEAQKLFHD----------------- 330

Human   645 KLRQSGLANE-------GTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDG 702
            .|...|:.:.       .:::.::...|.||.:...:||......|...:|    |...|
Yeast   331 VLYDHGVRDSVLEIYELSSESIFMAHQSQSSTSIANTFSSSSSSVNSLRTK----TEIYG----- 386

Human   703 TPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFD--------------SVAFGESQS 753
                   ||    .||.......|.:|::. :....|.|...              :::....:.
Yeast   387 -------VF----VPLTHCYSSTCSLEKLC-YSISCPNRLQQQANLHLKLGGGLKRNISLALDKE 439

Human   754 EDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVS 818
            :||:.         :|...|.:.|...|...:|||||.|.|||.||:..|::|:::...|.:::.
Yeast   440 DDERI---------SWTNSVPKSVWESLSKQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLL 495

Human   819 REGILSPSELR-----KIFSNLEDILQLHIGLNEQMKAVRKRNETS-VIDQIGEDLLTW--FSGP 875
            ...|: ||::|     .:|:::.:|..::   .|.:||:.:|...| :...|.:..|.:  |..|
Yeast   496 ETNII-PSDVRINFVKHVFAHINEIYSVN---REFLKALAQRQSLSPICPGIADIFLQYLPFFDP 556

Human   876 GEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKY 940
                    ..::.:::|:|..:|::::..:..|..|..:..::.|  |..:...:...:.|..:|
Yeast   557 --------FLSYIASRPYAKYLIETQRSVNPNFARFDDEVSNSSL--RHGIDSFLSQGVSRPGRY 611

Human   941 PLLLDNIAKYTEWPTEREKVK---KAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLS 1002
            .||:..|..:::..|:::.::   |..|..:.::..:::|...|:::..::..::::    |..:
Yeast   612 SLLVREIIHFSDPVTDKDDLQMLMKVQDLLKDLMKRIDRASGAAQDRYDVKVLKQKI----LFKN 672

Human  1003 EYPNVEELRNLDLTKRKMIHEGPL----VWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHS 1063
            ||.|:    .|:..|||:.|||.|    |.|.:...:.|:...||:::|:.|:   .:.|.:.|
Yeast   673 EYVNL----GLNNEKRKIKHEGLLSRKDVNKTDASFSGDIQFYLLDNMLLFLK---SKAVNKWH- 729

Human  1064 KILASTADSKHT------------------FSPVIKLST--------VLVRQVATDNKALFVISM 1102
                     :||                  ..|:.:..|        ||:.|..|.|....::..
Yeast   730 ---------QHTVFQRPIPLPLLFICPAEDMPPIKRYVTENPNCSAGVLLPQYQTSNPKNAIVFA 785

Human  1103 SDNGAQIYELV--------AQTVSEK 1120
            .....|.|::.        .||:.||
Yeast   786 YYGTKQQYQVTLYAPQPAGLQTLIEK 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF12	NP_056128.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62
		PDZ_signaling	71..145	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..346		9/20 (45%)
		RGS_LARG	349..570	CDD:188708	47/286 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..706		24/146 (16%)
		RhoGEF	791..976	CDD:279015	39/195 (20%)
		PH_LARG	995..1132	CDD:275425	36/164 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1179
ROM1	NP_011584.2	ROM1	1..1155	CDD:227709	177/936 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5422
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810