Protein Alignment ARHGEF12 and Arhgef12

DIOPT Version :10

• Sequence 1: NP_056128.1
• Gene: ARHGEF12 / 23365
• HGNCID: 14193
• Length: 1544
• Species: Homo sapiens
• Sequence 2: NP_001013264.2
• Gene: Arhgef12 / 367072
• RGDID: 1305111
• Length: 1545
• Species: Rattus norvegicus
• Alignment Length: 1545
• Identity: 1372/1545 - (88%)
• Similarity: 1441/1545 - (93%)
• Gaps: 1/1545 - (0%)

Human     1 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEI 65
            ||||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||
  Rat     1 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERSTSHDFDPTDSSSKKTKSSSEESRSEI 65

Human    66 YGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 YGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEV 130

Human   131 VKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMG 195
            ||||:||||||||||||||||||||||:|||||||||||||||||||||||:|||||||||||||
  Rat   131 VKLIRSGSYVALTVQGRPPGSPQIPLAESEVEPSVIGHMSPIMTSPHSPGAAGNMERITSPVLMG 195

Human   196 EENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSA 260
            |||||||||||||||||||||||||||||||||||..||||||||||||||||||||||||||||
  Rat   196 EENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTATQRLLKEIQEAKKHIPQLQEQLSKATGSA 260

Human   261 QDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPE 325
            |||||:.|||||||.||:|||||||||.|.|||.|||||||||||:||||||..|||:.||:.||
  Rat   261 QDGAVIAPSRPLGDALTLSEAETDPGDGLCRTDWSSGDASRPSSDSADSPKSSLKERVCLEDTPE 325

Human   326 KSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLH 390
            ::|.:||.||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 RTEGVQDADTQSLVGSPSTRGAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLH 390

Human   391 HVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPEL 455
            |||||||||||||||||||||.||||||||:|||||||||||||||:||||:|:|.|||||||||
  Rat   391 HVVSQFDPATLLCYLYSDLYKQTNSKETRRVFLEFHQFFLDRSAHLRVSVPEEISVDLEKRRPEL 455

Human   456 IPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAE 520
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||.|||
  Rat   456 IPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRGTLEKERACAE 520

Human   521 QIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKD 585
            |||.||||||||||||||::|||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 QIVTKIEEVLMTAQAVEEERSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKD 585

Human   586 KEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSG 650
            :||||||||||||||||||||||||||||||||||:||.|||||||.|||:|||.||.|||||||
  Rat   586 REGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMEIQKLRHPKHLSAPSSMSPELQDPAKLRQSG 650

Human   651 LANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPP 715
            :||||||.|||||:||||..|||:.|||||:|||||:||||:..||||.||..||..||||||||
  Rat   651 VANEGTDTGYLPASSMSSATSGAALSQEGGRENDTGAKQVGDAVAPGDCLDSIPRVPNTVFDFPP 715

Human   716 PPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG 780
            |.||||||||||||||.|||||||||||||:||||||||||||||||||||||||||||||||||
  Rat   716 PLLDQVQEEECEVERVAEHGTPKPFRKFDSIAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG 780

Human   781 LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGL 845
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
  Rat   781 LKPSEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHVGL 845

Human   846 NEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQT 910
            |||||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||
  Rat   846 NEQMKAVRKRNETSVIDHIGEDLLLWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQT 910

Human   911 FVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVN 975
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||.|||||||||
  Rat   911 FVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPPEREKVKKAADQCRQILNYVN 975

Human   976 QAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYT 1040
            |||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||:|||||
  Rat   976 QAVREAENKQRLEDYQRRLDTSSLKLSEYPNVDELRNLDLTKRKMIHEGPLVWKVNRDKSIDLYT 1040

Human  1041 LLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDN 1105
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1041 LLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDN 1105

Human  1106 GAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGIS 1170
            |||||||||||||||||||||||||||||||||||||||||..|.|||||||:|:|||.|.|.:|
  Rat  1106 GAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQPPPCEGDNDEEEPAKLKVEHHDLS 1170

Human  1171 VTGLQSPDRDLGLESTLISSKPQSHSLSTSGKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIA 1235
            |.|||||||.|||||.||||||||||::|.||||...|||...|||||||.:||.||....|.:.
  Rat  1171 VAGLQSPDRVLGLESPLISSKPQSHSMNTPGKSEAEHLFVTATQFAKEQHANGTFKEGDGGYPVT 1235

Human  1236 IPDSHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNS 1300
            |.|.|||||||||||||||||||||||||||||||||:.||||:.|.|||.||:..|.||.|.:.
  Rat  1236 ISDPHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKTTQEDWRSFSRYRPASEEAQADSGIPDL 1300

Human  1301 ENIKAYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEM 1365
            |::||.|:|||.|.|:|||||:|||.||||||||.|.:|||.||.||||||||:.||||::|||:
  Rat  1301 ESVKACHAGEGQMSFKTGTGDVATCDSPRTSTESCAVQDSVILASQDSQASNIIEMDHMLLTPEV 1365

Human  1366 P-TMEPEGGLDDSGEHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESST 1429
            | |.||||||||||||||||||||||:|||||||||.|||:|||:|||||.|||||||.||||||
  Rat  1366 PTTAEPEGGLDDSGEHFFDAREAHSDDNPSEGDGAVRKEEEDVNVRISGNCLILDGYDAVQESST 1430

Human  1430 DEEVASSLTLQPMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPS 1494
            |||:|||.||||:||:|:|:|:|||||||||..|:|||||.|||||||:||.|:|.:|.|:||||
  Rat  1431 DEEIASSFTLQPVTGLPSVDSSHQQQHSPQNAISEGAISPSTPEFLVQRRWRAVEDACSEVQSPS 1495

Human  1495 SCADSQSQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS 1544
            :..||||||:|||||||||||||||||||||:||||||||||.||.||||
  Rat  1496 AWTDSQSQILEYIHKIEADLEHLKKVEESYTLLCQRLAGSALPDKVSDKS 1545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF12	NP_056128.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62		58/60 (97%)
		PDZ_ARHGEF11-12-like	70..145	CDD:467282	73/74 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..346		79/98 (81%)
		RGS_LARG	349..570	CDD:188708	209/220 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..706		113/135 (84%)
		RhoGEF	791..976	CDD:214619	179/184 (97%)
		PH_LARG	995..1132	CDD:275425	134/136 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1138..1179		30/40 (75%)
Arhgef12	NP_001013264.2	PDZ_ARHGEF11-12-like	70..145	CDD:467282	73/74 (99%)
		RGS_LARG	349..570	CDD:188708	209/220 (95%)
		RhoGEF	791..976	CDD:214619	179/184 (97%)
		PH_LARG	995..1132	CDD:275425	134/136 (99%)