DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGEF12 and Arhgef12

DIOPT Version :9

Sequence 1:	NP_056128.1	Gene:	ARHGEF12 / 23365	HGNCID:	14193	Length:	1544	Species:	Homo sapiens
Sequence 2:	NP_001013264.2	Gene:	Arhgef12 / 367072	RGDID:	1305111	Length:	1545	Species:	Rattus norvegicus

Alignment Length:	1545	Identity:	1372/1545 - (88%)
Similarity:	1441/1545 - (93%)	Gaps:	1/1545 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEI 65
            ||||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||
  Rat     1 MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERSTSHDFDPTDSSSKKTKSSSEESRSEI 65

Human    66 YGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEV 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 YGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEV 130

Human   131 VKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMG 195
            ||||:||||||||||||||||||||||:|||||||||||||||||||||||:|||||||||||||
  Rat   131 VKLIRSGSYVALTVQGRPPGSPQIPLAESEVEPSVIGHMSPIMTSPHSPGAAGNMERITSPVLMG 195

Human   196 EENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSA 260
            |||||||||||||||||||||||||||||||||||..||||||||||||||||||||||||||||
  Rat   196 EENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTATQRLLKEIQEAKKHIPQLQEQLSKATGSA 260

Human   261 QDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPE 325
            |||||:.|||||||.||:|||||||||.|.|||.|||||||||||:||||||..|||:.||:.||
  Rat   261 QDGAVIAPSRPLGDALTLSEAETDPGDGLCRTDWSSGDASRPSSDSADSPKSSLKERVCLEDTPE 325

Human   326 KSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLH 390
            ::|.:||.||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 RTEGVQDADTQSLVGSPSTRGAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLH 390

Human   391 HVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPEL 455
            |||||||||||||||||||||.||||||||:|||||||||||||||:||||:|:|.|||||||||
  Rat   391 HVVSQFDPATLLCYLYSDLYKQTNSKETRRVFLEFHQFFLDRSAHLRVSVPEEISVDLEKRRPEL 455

Human   456 IPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAE 520
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||.|||
  Rat   456 IPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRGTLEKERACAE 520

Human   521 QIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKD 585
            |||.||||||||||||||::|||||||||||||||||||||||||||||||||||||||||||||
  Rat   521 QIVTKIEEVLMTAQAVEEERSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKD 585

Human   586 KEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSG 650
            :||||||||||||||||||||||||||||||||||:||.|||||||.|||:|||.||.|||||||
  Rat   586 REGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMEIQKLRHPKHLSAPSSMSPELQDPAKLRQSG 650

Human   651 LANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPP 715
            :||||||.|||||:||||..|||:.|||||:|||||:||||:..||||.||..||..||||||||
  Rat   651 VANEGTDTGYLPASSMSSATSGAALSQEGGRENDTGAKQVGDAVAPGDCLDSIPRVPNTVFDFPP 715

Human   716 PPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG 780
            |.||||||||||||||.|||||||||||||:||||||||||||||||||||||||||||||||||
  Rat   716 PLLDQVQEEECEVERVAEHGTPKPFRKFDSIAFGESQSEDEQFENDLETDPPNWQQLVSREVLLG 780

Human   781 LKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGL 845
            |||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
  Rat   781 LKPSEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHVGL 845

Human   846 NEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQT 910
            |||||||||||||||||.||||||.||||||||||||||||||||||||||||||||||||||||
  Rat   846 NEQMKAVRKRNETSVIDHIGEDLLLWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQT 910

Human   911 FVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVN 975
            ||||||||||||||||||||||||||||||||||||||||||||.||||||||||.|||||||||
  Rat   911 FVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPPEREKVKKAADQCRQILNYVN 975

Human   976 QAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYT 1040
            |||:||||||||||||||||||||||||||||:||||||||||||||||||||||||||:|||||
  Rat   976 QAVREAENKQRLEDYQRRLDTSSLKLSEYPNVDELRNLDLTKRKMIHEGPLVWKVNRDKSIDLYT 1040

Human  1041 LLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDN 1105
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1041 LLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDN 1105

Human  1106 GAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGIS 1170
            |||||||||||||||||||||||||||||||||||||||||..|.|||||||:|:|||.|.|.:|
  Rat  1106 GAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQPPPCEGDNDEEEPAKLKVEHHDLS 1170

Human  1171 VTGLQSPDRDLGLESTLISSKPQSHSLSTSGKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIA 1235
            |.|||||||.|||||.||||||||||::|.||||...|||...|||||||.:||.||....|.:.
  Rat  1171 VAGLQSPDRVLGLESPLISSKPQSHSMNTPGKSEAEHLFVTATQFAKEQHANGTFKEGDGGYPVT 1235

Human  1236 IPDSHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNS 1300
            |.|.|||||||||||||||||||||||||||||||||:.||||:.|.|||.||:..|.||.|.:.
  Rat  1236 ISDPHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKTTQEDWRSFSRYRPASEEAQADSGIPDL 1300

Human  1301 ENIKAYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEM 1365
            |::||.|:|||.|.|:|||||:|||.||||||||.|.:|||.||.||||||||:.||||::|||:
  Rat  1301 ESVKACHAGEGQMSFKTGTGDVATCDSPRTSTESCAVQDSVILASQDSQASNIIEMDHMLLTPEV 1365

Human  1366 P-TMEPEGGLDDSGEHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESST 1429
            | |.||||||||||||||||||||||:|||||||||.|||:|||:|||||.|||||||.||||||
  Rat  1366 PTTAEPEGGLDDSGEHFFDAREAHSDDNPSEGDGAVRKEEEDVNVRISGNCLILDGYDAVQESST 1430

Human  1430 DEEVASSLTLQPMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPS 1494
            |||:|||.||||:||:|:|:|:|||||||||..|:|||||.|||||||:||.|:|.:|.|:||||
  Rat  1431 DEEIASSFTLQPVTGLPSVDSSHQQQHSPQNAISEGAISPSTPEFLVQRRWRAVEDACSEVQSPS 1495

Human  1495 SCADSQSQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS 1544
            :..||||||:|||||||||||||||||||||:||||||||||.||.||||
  Rat  1496 AWTDSQSQILEYIHKIEADLEHLKKVEESYTLLCQRLAGSALPDKVSDKS 1545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGEF12	NP_056128.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		58/60 (97%)
		PDZ_signaling	71..145	CDD:238492	72/73 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..346		79/98 (81%)
		RGS_LARG	349..570	CDD:188708	209/220 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..706		113/135 (84%)
		RhoGEF	791..976	CDD:279015	179/184 (97%)
		PH_LARG	995..1132	CDD:275425	134/136 (99%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1138..1179		30/40 (75%)
Arhgef12	NP_001013264.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83682916
Domainoid	1	1.000	519	1.000	Domainoid score	I6612
eggNOG	1	0.900	-	-		E1_COG5422
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9088
Inparanoid	1	1.050	2590	1.000	Inparanoid score	I758
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46599
OrthoDB	1	1.010	-	-		D10776at9347
OrthoFinder	1	1.000	-	-		FOG0001574
OrthoInspector	1	1.000	-	-		oto137967
orthoMCL	1	0.900	-	-		OOG6_106011
Panther	1	1.100	-	-	LDO	PTHR45872
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2399
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310