DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OBSL1 and obsl1a

DIOPT Version :9

Sequence 1:	XP_011509159.1	Gene:	OBSL1 / 23363	HGNCID:	29092	Length:	1918	Species:	Homo sapiens
Sequence 2:	XP_005166286.1	Gene:	obsl1a / 796577	ZFINID:	ZDB-GENE-060503-649	Length:	2185	Species:	Danio rerio

Alignment Length:	2127	Identity:	723/2127 - (33%)
Similarity:	1086/2127 - (51%)	Gaps:	275/2127 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     9 GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGLLLTA 73
            |..|..|.:||||.|..|.:|.|||.:.|:|.|.|:||:..:.:....|.....||..:.|.::.
Zfish     5 GGAPRVLGYPRPVLVKCGTDAVLKCQIGGDPQPDVIWERKNESIHPEGRYRITQDGKVYTLNISG 69

Human    74 ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGS--------------- 123
            ....|||.|:|||:|..||.||||.:.|.| ...:.:.|||:.|.|....
Zfish    70 VTMEDAGQYICRAKNNIGETYAAATLKVQE-ETQEQQTQPAQAPPPQQNDVQVIPPEQDMKMKIQ 133

Human   124 ------------GEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSH 176
                        .:..|.||..|.|..|.||.:...:|:..|.|.|.:.|||||..|:|:::|:|
Zfish   134 QQVGVEKKKDPFQDSKPYFLIKPLSLRVDRGEDAAFSCKITGDPLPQVVWEKDGKQLNEIYESAH 198

Human   177 FALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQV--------------- 226
            :.:  |:.:   |....|:|...|.||.|||:|.|.|.||.|..||:|.|
Zfish   199 YHV--GQQD---GGWFQLKIFKTRTPDGGVYMCKAVNKHGEAITGAVLLVEPIPEHREGSMTNGY 258

Human   227 ---HQPPESPPADPDEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLP 288
               |..|:...|...:.|...|.    ..|.|.|.|||||||||||.|||:|||.|...|..::|
Zfish   259 TNGHYSPQHSRAKHSKEPHLNVS----KAKKFTVTEGKHAKFRCYVTGKPKPEIVWKRNGEIIMP 319

Human   289 DRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGR 353
            .||.|::.||:|.:.||||||:.:|.|||:|||.|:.|.|||||||.||.|.:||.|.|||.|.|
Zfish   320 SRRHLIFEDREGYYTLKVLYCKQQDTGLYICAASNALGNTLSAVQLSVKGPPVRFKRALQDSEFR 384

Human   354 EHGIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRV 418
            |..:|||||:||...|.|||:.|||||....||...::||.|||.|..:.|||||:|||||....
Zfish   385 ERDVAVLECEVPEESISTAWYLEDQRLQHGNKYNMEQKGTWRRLTIQNVGADDDGVYLCEMPDGG 449

Human   419 RTVANVTVKGPILKRLPRKLDVLEGENAVLLVETLEAGVEGRWSRDGEELPVICQS---SSGHMH 480
            :|:|.:.|||.|:|:|||:|:|:|||||...||..:..::..|.:||.:|....|:   |.|..|
Zfish   450 KTIAELAVKGTIVKKLPRRLEVMEGENAAFFVEVEQDDMDICWFKDGLQLQETHQTIIKSFGKTH 514

Human   481 ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPPILAEMFKG-HKNTVLLTWKPPEPA 544
            .||....:.:|:|.:||..|.|.|::.||||..:|.||..|:..:|... .:|.|:|:|   .|:
Zfish   515 ILVFVNTSYQDSGTITFMAGRSTTSSKLRVKTARHCPPICPVGVQMNTDCCQNGVVLSW---SPS 576

Human   545 PE-----TPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHV 604
            |.     |..:|.||||||||::|.:|.:.|...:.||.||.||.|||:|||||.|:.:|||.||
Zfish   577 PNLQNSTTKSVYVLERQEVGSQEWQRCLTTETGTSAEVLGDSVPCEGDFRFRICCVNKYGRSGHV 641

Human   605 VFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALR 669
            .|....||.|..::.:.|::..|.:|||||||::||:.:.||||||.::|:.:|          .
Zfish   642 EFPKVVHLAPGPKIKSPLKNAVVTEGEDAVFSIELSSELIGTWFLNSQQLQQSE----------H 696

Human   670 YRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHI--LSPQD---------- 722
            :.:.|...||.|.:..|.:...||.:.|...||:|||:|.|:...|..  ||..|
Zfish   697 FSMTQSKNQHILRIRQVPNVYDGAEITFIATGVRDSASLQIKVCEVKFLPLSEMDTKKSTELGNP 761

Human   723 -----RVS-----------------------------------------------------LTFT 729
                 .||                                                     |||.
Zfish   762 IVLYCEVSQPTATVQWFKDGKELHAEDGLNIQSDGNMRRIIIHSAEYSHSGVYTCQSNNDILTFN 826

Human   730 TS--------------ER---------VVLTCELSRVDFPATWYKDGQKVEESELLVVKMDGRKH 771
            .:              ||         ||||||:|:.:.|:.|:|||..|.:|:.:.::.:|...
Zfish   827 VNVEAPPVLFKEIKAEERQKSAMELDPVVLTCEISQPEAPSCWFKDGVAVFQSDNITIQSEGNMR 891

Human   772 RLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPREHVFVHAITSECVMLACEVDREDA 836
            |||:..|::.|:|.:.|:....:..|.|.:::||:.||||::.:.:....||.::|.||:.|.:.
Zfish   892 RLIIRSAELVDAGTYTCQAGDQTMSFSVNIKEPPITIVDPKDDIHMERYVSEEIVLNCELSRSNG 956

Human   837 PVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFTVTITDVSSWIVY 901
            .|:|:|||.:::|:|.:.|..|||:||:::......|.||:.|.||.:..:|.:.||:.....|.
Zfish   957 EVQWFKDGLKLQETDNIRLSAEGPYRRVIIFCASKRDSGEYVCDAGGDSVFFQLLITEAPVRFVS 1021

Human   902 PS-GKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDS 965
            || .:|.|..:..|::||.||:.:..|||.|..||.||.|:..|.|:.:...||||:|...::||
Zfish  1022 PSESEVEVCIMSSEKLVLNCEISKADAEVCWFCDGMEVDENDNLKLEDDGIYRRLVIPCTTIDDS 1086

Human   966 GEYLCEIDDESASFTVTVTEPPVRIIYPRDEVTLI-AVTLECVVLMCELSREDAPVRWYKDGLEV 1029
            .||:||..|::.:|.|.:.||||::...:...::. :...:.|:|..|:|||:|.|.|.|||::|
Zfish  1087 AEYVCETADDAVTFWVKIEEPPVKLSSSKQSGSITESFAGDPVILELEVSRENAEVCWMKDGMKV 1151

Human  1030 EESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLHFG 1094
            |||..:.:..:|...::.:.....:|.|.:.|:|.||:..|.|.:|..|..|::......:....
Zfish  1152 EESSNITITENGLTRKITIHCPTLKDSGIYTCNAIDDTMDFKVKITEAPVTILNKDQIKNEHKVM 1216

Human  1095 APGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEA 1159
            ....|.:.||::.|...|.|||:|..:|.::...|..||..|:|.:..|:.:|:|||..:.:::.
Zfish  1217 LYDDVVMECELSSANGVVTWYKNGSPIEENERFCLEEEGTFRSLVILCAELQDSGEYTLDAKNDT 1281

Human  1160 ITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPVVWSHNGRPVQEGEGLELHAE 1224
            .:|:|.:.||.|:.:.....|....:..|:.::|:||:|||.|||.|..|.:.:...|...:.::
Zfish  1282 FSFHVTVQEPSVKIIGNSGDPDYQEMVTGDDLILACEVSRANAPVKWLFNEKVLIPDERTHIESQ 1346

Human  1225 GPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLE- 1288
            |..|.|.|.....:.:|.|.|.:    ....:...|:|.||||..:..|    .|....|.:.|
Zfish  1347 GTLRKLTISNILVSDSGKYMCDA----VDDKMLTVVKVQEPPVEFLNKE----EVNLVTGYEAEP 1403

Human  1289 --LVVHLSGPGGPVRWYKD-----GERL--ASQG------------------------------- 1313
              |...:|.|...|||.||     |||.  ||.|
Zfish  1404 VTLTAMVSRPNAQVRWLKDWTQISGERFHTASLGLTRTFTIDPLKKLDSGEYTCDANSDEMHFSL 1468

Human  1314 -----------------------------------RVQLEQAGARQV---------------LRV 1328
                                               .||.::.|...:               |.:
Zfish  1469 LVKDMRIKFVKPLVDTVAHKDGMITLCCELCKAKADVQWKKDGVEIIPSRRFSIRANETERSLTI 1533

Human  1329 QGARSGDAGEYLCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWL 1393
            ......|||||:|::..||....:.||.|.:|:.::||...||.||:||.|:|.|||.|..:.||
Zfish  1534 HRITKEDAGEYVCESKDDSTSARLRVELPRVVEFLTELHNTTVMEGEDAMFKCVVSPDDVQLVWL 1598

Human  1394 RNGAVVTPGPQVEMAQNGSSRILTLRGCQLGDAGTVTLRAGSTATSARLHVRETELLFLRRLQDV 1458
            .:|..:.|..:.::.||.....|.:...||.|:..:|..|....:.|.|.|:|.::||.:|::.|
Zfish  1599 MDGEPIKPSDRFQIEQNSLCHTLIIHKVQLLDSSRITAEAEGLISKASLKVQEAQVLFTKRMEAV 1663

Human  1459 RAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCE 1523
            .|||..:..||.|...  .:|.|:|:|.|..:....:..::|:|....|.|..:.|:|:|||.||
Zfish  1664 MAEEFGEATLETEVSL--ESGEVQWMRQGVVIQPGPKHKLSQNGCKRILTITNLSLSDRGTYRCE 1726

Human  1524 SHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGVTGEWARGGVQLYPGPKCHIH 1588
            :.||||..:|:|.||::.:.:.:.||...|..:|:|::|||...|.|.|.:.|:::.|.....:.
Zfish  1727 TLHDRTQVKLNVEPRKIAIRKGMMDVETFERETASFEVELSHTDVEGVWQKDGLRIKPNNNWRVS 1791

Human  1589 SDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS 1653
            |:|..|.|.|:.|.:.|:|.:.|:|:.||..|||:|:|.||.|.:...|:.:.|..:...|||||
Zfish  1792 SNGRVHGLTLSNLTMEDTGSIVFSAEGLRNTARLVVKETPVAIFKKLSDVRIEEESSVVLECELS 1856

Human  1654 QALADVTWEKDGNALTPSPRLRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTVRERT 1718
            :...||.|:|:|..|..|..||:.::|.:|.||:..|..||:|.|:|.:|..... .:|.|.|..
Zfish  1857 RPNVDVRWQKNGIELKSSKTLRIYSMGRKRCLQILECSISDSGLYTCEIGDLSTS-CKLEVYEHE 1920

Human  1719 VAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAE 1783
            :.:::.|..:..:|...|.|.|.:|..:..|.|...|..:||.:.::.|.||.||.|::..::||
Zfish  1921 LELITGLEDLWIKEDQNAVFMCELSMEDMPGEWYKNGSRIRPTSTIKTRTEGTKHFLLICNVKAE 1985

Human  1784 DAGEVRFQAGPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTVSRSGGHVCWLREGAEL 1848
            |:||::|.:...:|:|.||||.||:.:.| |.|::|.|...|.:||.|||.....|.|.||..||
Zfish  1986 DSGEIKFVSKQVESVACLEVEELPVSIVR-PLRDRTALEKHRVILECTVSSPNCDVTWYRENEEL 2049

Human  1849 CPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVEA 1895
            ...:..|:...|..|.|||..|..||:|||..:.|:.::..:|:|||
Zfish  2050 ESTEHMEIIQEGCYHKLVIQQVALEDEGTYSIEVGEHTSIAKLMVEA 2096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OBSL1	XP_011509159.1	IG_like	18..101	CDD:214653	34/82 (41%)
		IGc2	25..88	CDD:197706	22/62 (35%)
		IG	134..226	CDD:214652	37/91 (41%)
		IGc2	142..216	CDD:197706	27/73 (37%)
		IG	252..336	CDD:214652	51/83 (61%)
		Ig	252..336	CDD:299845	51/83 (61%)
		I-set	342..426	CDD:254352	45/83 (54%)
		Ig	358..421	CDD:143165	34/62 (55%)
		IG_like	435..510	CDD:214653	29/77 (38%)
		FN3	518..602	CDD:238020	39/89 (44%)
		IG	725..802	CDD:214652	30/152 (20%)
		Ig	734..802	CDD:143165	24/67 (36%)
		Ig	825..893	CDD:143165	24/67 (36%)
		Ig	916..984	CDD:143165	29/67 (43%)
		IG	1005..1074	CDD:214652	25/68 (37%)
		Ig	1007..1075	CDD:143165	25/67 (37%)
		IG_like	1097..1154	CDD:214653	20/56 (36%)
		IGc2	1099..1159	CDD:197706	20/59 (34%)
		Ig_Semaphorin_C	1178..1267	CDD:143180	25/88 (28%)
		IG	1180..1262	CDD:214652	22/81 (27%)
		IG	1282..1343	CDD:214652	26/151 (17%)
		IGc2	1283..1341	CDD:197706	25/148 (17%)
		I-set	1361..1444	CDD:254352	28/82 (34%)
		ig	1364..1430	CDD:278476	24/65 (37%)
		IG_like	1456..1535	CDD:214653	28/78 (36%)
		Ig	1481..1536	CDD:143165	20/54 (37%)
		I-set	1541..1624	CDD:254352	28/82 (34%)
		I-set	1631..1714	CDD:254352	29/82 (35%)
		Ig	1635..1724	CDD:299845	30/88 (34%)
		I-set	1725..1803	CDD:254352	26/77 (34%)
		Ig	1814..1893	CDD:299845	30/78 (38%)
		IG_like	1815..1893	CDD:214653	29/77 (38%)
obsl1a	XP_005166286.1	I-set	8..97	CDD:254352	36/88 (41%)
		Ig	25..97	CDD:299845	28/71 (39%)
		Ig	150..243	CDD:299845	40/97 (41%)
		I-set	150..243	CDD:254352	40/97 (41%)
		I-set	284..367	CDD:254352	51/82 (62%)
		Ig	296..367	CDD:299845	42/70 (60%)
		Ig	389..444	CDD:299845	31/54 (57%)
		I-set	464..544	CDD:254352	30/79 (38%)
		FN3	567..638	CDD:238020	35/73 (48%)
		I-set	653..739	CDD:254352	34/95 (36%)
		IG	757..821	CDD:214652	2/63 (3%)
		IGc2	759..820	CDD:197706	2/60 (3%)
		I-set	844..921	CDD:254352	25/76 (33%)
		Ig	854..922	CDD:143165	24/67 (36%)
		Ig	945..1006	CDD:299845	23/60 (38%)
		IG	1125..1197	CDD:214652	25/71 (35%)
		Ig	1126..1185	CDD:299845	20/58 (34%)
		Ig	<1234..1288	CDD:299845	18/53 (34%)
		IG_like	1302..1376	CDD:214653	21/77 (27%)
		Ig	1308..>1370	CDD:299845	20/65 (31%)
		ig	1395..1460	CDD:278476	16/64 (25%)
		IG	1396..1462	CDD:214652	16/65 (25%)
		I-set	1476..1559	CDD:254352	12/82 (15%)
		Ig	1499..1559	CDD:299845	12/59 (20%)
		I-set	1566..1649	CDD:254352	28/82 (34%)
		Ig	1568..1657	CDD:299845	31/88 (35%)
		Ig	<1672..1727	CDD:299845	18/56 (32%)
		IG_like	<1683..1739	CDD:214653	20/55 (36%)
		IG_like	1751..1827	CDD:214653	28/75 (37%)
		I-set	1836..1916	CDD:254352	28/80 (35%)
		IGc2	1845..1904	CDD:197706	24/58 (41%)
		I-set	1924..2005	CDD:254352	26/80 (33%)
		I-set	2011..2094	CDD:254352	31/83 (37%)
		Ig	2020..2083	CDD:299845	26/62 (42%)
		I-set	2101..2184	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330017
Domainoid	1	1.000	115	1.000	Domainoid score	I23275
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H28013
Inparanoid	1	1.050	1223	1.000	Inparanoid score	I1536
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG41617
OrthoDB	1	1.010	-	-		D11490at33208
OrthoFinder	1	1.000	-	-		FOG0009243
OrthoInspector	1	1.000	-	-		oto51561
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	1	1.100	-	-	O	PTHR13817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6986
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.410