DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OBSL1 and bt

DIOPT Version :9

Sequence 1:	XP_011509159.1	Gene:	OBSL1 / 23363	HGNCID:	29092	Length:	1918	Species:	Homo sapiens
Sequence 2:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster

Alignment Length:	2291	Identity:	445/2291 - (19%)
Similarity:	784/2291 - (34%)	Gaps:	679/2291 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    12 PCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF---PADGAEHGLLLTA 73
            |.|::.|:..:...|.....:|.:|..|.|.:.|.:...::....|..|   |....::.::|..
  Fly     9 PSFVKKPQLHQEDDGNRLIFECQLLSSPKPDIEWFRSDNKVVEDVRTKFKIQPVGENKYTVVLEL 73

Human    74 --ALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG-APVFLTGPR 135
              .:.||||:|..:|:|.:||  .:|::.:...||.:|:    |:.:      :| ||.|...|.
  Fly    74 DDVVETDAGLYKVKAKNKSGE--VSASINLNFTPADEPK----EKQI------DGFAPTFAKKPA 126

Human   136 SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDE------VWDS---SHFALQPGRAEDGPGAS 191
            .:....|..::..||....|.|.:.|..:|.|:.|      ..|.   |:||
  Fly   127 IRQEEDGKRLLFECRVNADPIPAIIWFHNGAAVKESERHKITVDKDVHSYFA------------- 178

Human   192 LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF- 255
             .|.||...:.|:|.|..:|:|..|.:.|...|..         |.||||.|  |..:....||
  Fly   179 -TLEILNVTVEDAGKYKVNAKNELGESNATISLNF---------DSDEAPVP--ESAEGIKPTFT 231

Human   256 ------WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGF----VLKVLYCQ 310
                  ...:|.:..|.|..:|.|.|.:.|......|....|..|....|...    .|::....
  Fly   232 ERPVIRQSEDGGNVTFECRCVGDPTPTVTWSHGETELNESNRYKMSLTMDQKLYHIACLEISSVV 296

Human   311 AKDRGLYVCAARNSAGQTLSAVQLHV----------KEPRLRFTRPLQDVEGREHGIAVLECKVP 365
            :.|:|.|...|:|..|..::.:.|:.          |.||.    |.:....:|..:.::||.:.
  Fly   297 SSDQGEYRAQAKNKHGSGVATINLNFESGSKKIPDGKSPRF----PKKPTIRQEEDLLIMECVLE 357

Human   366 NSRIP-TAWFRED------QRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---EMRGRVRT 420
            ...:| ..|:..:      ||....|| ...::..:..|.|.....:|.|.|.|   .|.|  .:
  Fly   358 AHPVPDIVWYCSEKEICNNQRTKMTRK-AITKDSYILTLEIQNPTKEDGGNYRCNAINMYG--ES 419

Human   421 VANVTVK----------GPILKRLPRKLDVLEGENAVLLVETLEAGVEGR------WSRDGEELP 469
            .||:.:.          .|.....||   ::..|:..|:  |::...:.:      |.| |::|
  Fly   420 NANIALNFQGASDANGFAPSFIEKPR---IIPNESGTLI--TMKCKCKAKPEPTVTWYR-GQDL- 477

Human   470 VICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKC-VKHSPPGPPILAEMFKGHKNT 533
             :.:|....::..|:    .||..|:|..:.:...|.....:| ||:         |..:.:.|.
  Fly   478 -VEKSKKIKINTTVI----AEDTYELTLEIKDPGATDGGTYRCNVKN---------EYGESNANL 528

Human   534 VLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSEGDYRFRICTVSGH 598
            .|.....|||..|.|..  :|:..:.||:               .|..|..|       |.|...
  Fly   529 NLNIEAEPEPEGEGPTF--IEKPRIVSEN---------------NGKLVIME-------CKVKAD 569

Human   599 GRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQV 663
            .: |.|:                                         ||.|||.:|
  Fly   570 PK-PDVI-----------------------------------------WFRNGEVIK-------- 584

Human   664 EPGALRYRIEQKGLQHRLILHAVKHQ--DSGALVGFSCPGVQD-----SAALTIQESPVHILSPQ 721
            |...::..|||:|.|:.:.|..:..|  |||.   :.| .:::     :|.||:....|.::..:
  Fly   585 ESNKIKTFIEQRGDQYYIKLELLDPQLEDSGL---YKC-NIKNTLGELNANLTLNIEIVPVIKDK 645

Human   722 DRVSLTFTTSERVVLTCEL-SRVDFPATWYKDGQKVEESELLVVKMDGRKH-----RLILPEAKV 780
            .:: :.......||:.|.: |:.:...||||:...|:||:..|.:::..|.     :|.:.:.:.
  Fly   646 PKI-IKIIKKRTVVIECTVASKFEPKCTWYKETSTVKESKRHVYQVEQTKEGEFAVKLEINDVEE 709

Human   781 QDSGEFEC-----RTEGVSAFFGVTVQDPPVHIVD-PRE---------------HVFVHAITSEC 824
            .|.|.::.     :.|.||..         |::|| |.|               .....:.|.|.
  Fly   710 SDKGAYKLVASNEKGEAVSQI---------VNLVDIPEEERKPCKPEISRKLADQKVAESKTFEL 765

Human   825 VMLACEVDREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYFT 889
            ::...:.||: ..|.|||....:.|:..:....:|...||...:.:......::.:..:|..
  Fly   766 LVSLSQTDRK-CKVEWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTSNYKVIVTNEVG--- 826

Human   890 VTITDVSSWIVYPSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVV---------ESPALL 945
               .|.||           ..:.:|:|....|. :| .|...||:.:||.         ||...:
  Fly   827 ---KDESS-----------CKITVEKVAKKKEE-KP-KEKEKTKNEKEVEQKEMEEDKNESGQSV 875

Human   946 LQKED----------------TVRRLVL----------PAVQLEDS-GEYLCE------------ 971
            .|.|.                ||:..:|          .:|:|:|| |..:.|
  Fly   876 AQTEGRINIEQISEGDPKEELTVKEEILDKRDTQEVKESSVELQDSAGHEVPEPKKATSDSKLDQ 940

Human   972 -----ID-----DESASFT---VTVTEP------------------------PVRIIYPRDEVTL 999
                 :|     |:|.|.|   |::.||                        ...|:..::|::.
  Fly   941 SNQKNLDKKHKTDQSESKTNKNVSLAEPIKSNKQESEEQQATEQIGLKKVDRKASIVSVKEEISS 1005

Human  1000 IAVTLECVVLMCELSREDAPVRWYKDGLEVEES------EALV---------------------L 1037
            .......:....|::.:|......:..|.||||      .:::                     |
  Fly  1006 DVRRKSTIKAKEEITVDDKKASSRRSSLAVEESNTESRRSSIIDKKPLEQVDNKPIDANKNPQPL 1070

Human  1038 ERDGPRCR--------LVLPAAQPEDG---------GEFVCDAGDDSAFFTVTVTAPPERIVHPA 1085
            :.:.||.:        .|:...:|::|         .:...:|...:........|.|:....|.
  Fly  1071 KEEIPRLKPAEKRRTSKVIEEPKPDEGLPKLRKASIAQVKEEAKPAAPKLKAKAKAKPKYEELPE 1135

Human  1086 ----------------------ARSLDLHFGAPGRVELRCEVAPAGSQ---VRWYKDGLEVEASD 1125
                                  ||.|::    |.::|.  .:..:|.:   |...|:|:. :.:|
  Fly  1136 IPDYERPQLEKYEKSDFTPSDFARDLEI----PNKMEK--PIIDSGKKEPAVLAQKNGIP-KKTD 1193

Human  1126 ALQLGAEGPTRTLTLPHAQPEDAGEYVCETRHEAITFNVILAEPPVQFLALETTPSPLCVAPGEP 1190
            .::..|:.| :.|.:...:..|.|    :.|..|:...||: ||..:.|.|....:.  ....:|
  Fly  1194 IIEQYADEP-KGLKVGKGKLPDEG----DGRDGAVLKPVII-EPEKEILDLGNKKNN--QHADKP 1250

Human  1191 VVLSCELSRAGAPVVWSHNGRPVQE----GEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAP 1251
            .||.....|..:.:.......|:|.    |..|:...:..|     :.|.|..|...|..:....
  Fly  1251 TVLDIIKQRRRSSIRNLMTKEPIQNESFLGVVLKPVIKDTR-----EQAAPQQAIQLTKANATEQ 1310

Human  1252 GAPSLSFTVQVAEPPVRVVAPEAAQT----------------------RVRSTP--------GGD 1286
            .:|:.:...|||:    :..||...|                      ..:|||        |.:
  Fly  1311 FSPTKAVKAQVAD----LKKPETLATLEDNYERPVLEKYDPFSIDKTKSEKSTPSIITPDIRGPE 1371

Human  1287 LELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIFL 1351
            ::|         ||:..|:.:               ::|.::|....||
  Fly  1372 VKL---------PVQETKEEK---------------QKVPKMQPPAPGD---------------- 1396

Human  1352 VSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDADVTWLRNGAVVTP---GPQVEMAQNGSS 1413
                 |..::::.|..|....|           ||.      |.|:::.|   |.:..:..|...
  Fly  1397 -----PPKIEVIREKRPSLAPE-----------PPS------RRGSLIPPADTGRRPSLIINDEK 1439

Human  1414 RILTLRGCQLGDAGTVTLRAGSTATSARLH---------VRETELLF------LRRLQD------ 1457
            :   ||..::.|  |..||.|......|..         |::.|.|.      ||.:.|
  Fly  1440 K---LRPGEVMD--TRLLRPGEVGEGQRRRPSIDVRRPSVQDLEDLINKPSTPLRDVGDGGPPSI 1499

Human  1458 VRAEEGQDVCLEVETG--RVGAAGA----VRWVRGGQPLPHDSRLSMAQDGHIHRLF-------- 1508
            |..:|...| :|..|.  .||..|:    .::.:|...:....|.....||..:.:.
  Fly  1500 VDVQESYSV-VEDSTAYLTVGVEGSPAPTFKFYKGVSEILEGGRFKFLTDGQTNTITLCMRKCKP 1563

Human  1509 ------------IHGVILADQGTYGCES------------------------------HHDRTLA 1531
                        |||...|:...|..:|                              ..::.|.
  Fly  1564 NDESKYKIVVSNIHGEDSAEMQLYVSDSSGMDFRAMLKKRRYQKWDKDEQDPNWGDLKETEKPLP 1628

Human  1532 RLSVRPRQLR-VLRPLEDVTISEG--GSATFQLELSQEGVTGEWARGGVQLYPGPKCHIHSDGHR 1593
            .|....|::. .|.||.|....||  ....|:...|:.....:|.....:::.|.|.....:...
  Fly  1629 ALKKVERKVESFLSPLIDQFAKEGKDKKVVFEARFSKPNCKPKWLFRKDEVFTGSKFKFKQENDT 1693

Human  1594 HRLVLNGLGLADSGCVSFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDT---ATFECELSQA 1655
            ::|::....:.|:|..:.....:...|.|.|.|...|........:..||.|   .|.||.:|.:
  Fly  1694 YQLIITTPKVEDTGKYTIEIGGVSSTAFLNVEEADPTYTFTKPLKKKLEGFTQHETTLECSVSSS 1758

Human  1656 LADVTWEKDGNAL-TPSPR--LRLQALGTRRLLQLRRCGPSDAGTYSCAVGTARAGP----VRLT 1713
            :|:|.|.|:...| :..||  :.....|..:|: ::.....|||.|.|.:...   |    ..|.
  Fly  1759 MANVHWFKNNTKLESDDPRYLISKDINGNLKLI-IKDSVLDDAGLYRCQLDKQ---PDKTECNLK 1819

Human  1714 VRERTVAVLSELRSVSAREGDGATFECTVSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLS 1778
            |.|.....:..|:|....|.|..|..|.:.:.....:|...|..::|..|::|.::|:|..||:.
  Fly  1820 VTEYPYKFVKVLKSQQCIEKDTVTLACEIDDAMGEVQWLRNGEEIKPDKRIQIVKDGRKRKLVIK 1884

Human  1779 ELRAEDAGEVR--FQAGPAQSLALL-----------EVEALPLQMCRHPPREKTVLVGRRAVLEV 1830
            :.:..|||:.:  ..|...:|..::           :.||:        .|||       .:|::
  Fly  1885 DCKVTDAGQFKCTTNADTTESEIIINYQNRFNKKLKDTEAV--------EREK-------LILDI 1934

Human  1831 TVSRSGGHVCWLREGAELCPGDKYEMRS-HGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLVE 1894
            .:........|...|..:.|.:..|::: .|..|.|:...:...::|...|::||.|:..:|.:.
  Fly  1935 ELQDQTAPCDWKFNGEPIVPSESIEIKNMGGGKHQLIFSSLDMSNEGEITCESGQLSSKCKLSIR 1999

Human  1895 AGPAKPLVHGLRCMDK 1910
            .|.::|   .:.|.||
  Fly  2000 KGESRP---NIDCPDK 2012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OBSL1	XP_011509159.1	IG_like	18..101	CDD:214653	21/87 (24%)
		IGc2	25..88	CDD:197706	16/67 (24%)
		IG	134..226	CDD:214652	25/100 (25%)
		IGc2	142..216	CDD:197706	21/82 (26%)
		IG	252..336	CDD:214652	21/94 (22%)
		Ig	252..336	CDD:299845	21/94 (22%)
		I-set	342..426	CDD:254352	20/93 (22%)
		Ig	358..421	CDD:143165	16/72 (22%)
		IG_like	435..510	CDD:214653	16/80 (20%)
		FN3	518..602	CDD:238020	16/83 (19%)
		IG	725..802	CDD:214652	19/87 (22%)
		Ig	734..802	CDD:143165	19/78 (24%)
		Ig	825..893	CDD:143165	11/67 (16%)
		Ig	916..984	CDD:143165	27/128 (21%)
		IG	1005..1074	CDD:214652	14/112 (13%)
		Ig	1007..1075	CDD:143165	14/111 (13%)
		IG_like	1097..1154	CDD:214653	11/59 (19%)
		IGc2	1099..1159	CDD:197706	12/62 (19%)
		Ig_Semaphorin_C	1178..1267	CDD:143180	17/92 (18%)
		IG	1180..1262	CDD:214652	14/85 (16%)
		IG	1282..1343	CDD:214652	11/68 (16%)
		IGc2	1283..1341	CDD:197706	10/65 (15%)
		I-set	1361..1444	CDD:254352	18/94 (19%)
		ig	1364..1430	CDD:278476	14/68 (21%)
		IG_like	1456..1535	CDD:214653	21/140 (15%)
		Ig	1481..1536	CDD:143165	12/104 (12%)
		I-set	1541..1624	CDD:254352	16/85 (19%)
		I-set	1631..1714	CDD:254352	23/92 (25%)
		Ig	1635..1724	CDD:299845	25/98 (26%)
		I-set	1725..1803	CDD:254352	20/90 (22%)
		Ig	1814..1893	CDD:299845	17/79 (22%)
		IG_like	1815..1893	CDD:214653	17/78 (22%)
bt	NP_001162825.1	I-set	9..101	CDD:254352	23/93 (25%)
		Ig	26..100	CDD:143165	19/75 (25%)
		I-set	119..210	CDD:254352	26/104 (25%)
		Ig	136..209	CDD:143165	22/86 (26%)
		I-set	228..320	CDD:254352	20/91 (22%)
		IGc2	242..312	CDD:197706	17/69 (25%)
		I-set	335..425	CDD:254352	22/96 (23%)
		Ig	350..423	CDD:143165	17/75 (23%)
		Ig	436..530	CDD:299845	22/114 (19%)
		I-set	438..532	CDD:254352	23/114 (20%)
		I-set	545..636	CDD:254352	31/168 (18%)
		Ig	560..633	CDD:143165	25/133 (19%)
		Ig	657..731	CDD:143165	19/82 (23%)
		I-set	746..835	CDD:254352	16/106 (15%)
		Ig	1496..1586	CDD:299845	16/90 (18%)
		IG_like	1503..1588	CDD:214653	15/85 (18%)
		I-set	1639..1724	CDD:254352	16/84 (19%)
		IG	1750..1821	CDD:214652	20/74 (27%)
		IGc2	1750..1806	CDD:197706	17/56 (30%)
		I-set	1826..1909	CDD:254352	20/82 (24%)
		Ig	1831..1897	CDD:299845	18/65 (28%)
		I-set	1914..1998	CDD:254352	19/98 (19%)
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710