DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OBSL1 and unc-89

DIOPT Version :9

Sequence 1:	XP_011509159.1	Gene:	OBSL1 / 23363	HGNCID:	29092	Length:	1918	Species:	Homo sapiens
Sequence 2:	NP_001020985.1	Gene:	unc-89 / 171990	WormBaseID:	WBGene00006820	Length:	8081	Species:	Caenorhabditis elegans

Alignment Length:	2154	Identity:	515/2154 - (23%)
Similarity:	821/2154 - (38%)	Gaps:	438/2154 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    11 PPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGG-----------QQLAASERLSFPADG 64
            ||.|:....|:.|.......|...|:|.|.|.|.|.|..           |:..|....|...:.
Worm  3383 PPEFVEKLSPLEVKEKESTTLSVKVVGTPEPSVEWFKDDTPISIDNVHVIQKQTAVGSFSLTIND 3447

Human    65 AEHGLLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLE---PPASDPELQPAERPLPSPGSGEG 126
            |..|         |.|:|.|||||.||||...|...::.   ||....:|:|.|
Worm  3448 ARQG---------DVGIYSCRARNEAGEALTTANFGIIRDSIPPEFTQKLRPLE----------- 3492

Human   127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGAS 191
                   .|.|..|.....|:     |.|.|.:.|.||...::  .|:||..     |:|.....
Worm  3493 -------VREQETLDLKVTVI-----GTPVPNVEWFKDDKPIN--IDNSHIF-----AKDEGSGH 3538

Human   192 LALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTFW 256
            ..|.|..||..|.|||.|.|.|..|.|:..|.:.|.:..|:|         ..|:.|    |.:.
Worm  3539 HTLTIKQARGEDVGVYTCKATNEAGEAKTTANMAVQEEIEAP---------LFVQGL----KPYE 3590

Human   257 VNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLM-YRDRDGGFVLKVLYCQAKDRGLYVCA 320
            |.:||.|:....|.||||||::|..:|.|:..|.:.:: .:..:|...|.:......|.|.|.|.
Worm  3591 VEQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIEKKGENGSHTLVIKDTNNADFGKYTCQ 3655

Human   321 ARNSAGQTLSAVQLHV----------KEPRLRFTRPLQDVEGREHGIAVLECKVPNSRIP-TAWF 374
            |.|.||:..:..:|.:          :|.:..|..||::....|....||||||.....| ..:|
Worm  3656 ATNKAGKDETVGELKIPKYSFEKQTAEEVKPLFIEPLKETFAVEGDTVVLECKVNKESHPQIKFF 3720

Human   375 REDQRLLPCR-----KYEQIEEGTVRRLIIHRLKADDDGIYLCE---MRGRVRTVANVTVK---- 427
            :.||   |..     :.|.:|:|.: :|.|...|.:|.|.|.||   :.|:..|.|::.::
Worm  3721 KNDQ---PVEIGQHMQLEVLEDGNI-KLTIQNAKKEDVGAYRCEAVNVAGKANTNADLKIQFAAK 3781

Human   428 ----------------------------------GPILKRLPRKLDVLEGENAVLLVETLEAGVE 458
                                              .|....|.|...|.|.:.|:     |:..|:
Worm  3782 VEEHVTDESGQLEEIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAI-----LKCKVK 3841

Human   459 G------RWSRDGEELPVICQSSSGHMH----ALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCV 513
            |      :|:::|:|:.:..:..:.|..    .|....||:.||||......|...:....
Worm  3842 GEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSAWTE---- 3902

Human   514 KHSPPGPPIL----AEMFKGHKNTVLLTWKPPEPA----PETPFIY-RLERQEVGSEDWIQCFSI 569
                 ||.|:    |....|.....|   :|.:||    .||..:. ::..:...|..|.
Worm  3903 -----GPIIVTLEGAPKIDGEAPDFL---QPVKPAVVTVGETAVLEGKISGKPKPSVKWY----- 3954

Human   570 EKAGAVEVPGDCVPSEG-------------------DYRFRICTVSGH-----------GRSPHV 604
             |.|....|.|.|..|.                   :||   |..|..           .:.|..
Worm  3955 -KNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYR---CEASNEFGDVWSDVTLTVKEPAQ 4015

Human   605 VFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQGT-----WFLNGEELKSNEPEGQVE 664
            |..|         ....|..:||.:.|.|.|...:|    ||     ||.:|..||        |
Worm  4016 VAPG---------FFKELSAIQVKETETAKFECKVS----GTKPDVKWFKDGTPLK--------E 4059

Human   665 PGALRYRIEQKGLQHRLILHAVKHQDSGALVGFSCPGVQDSAALTIQESPVHILSPQDRVSL--- 726
            ...:.:.....|.| ||::...|..|.|   .:... |.:.|.:...:.|:.:: |.:.:.:
Worm  4060 DKRVHFESTDDGTQ-RLVIEDSKTDDQG---NYRIE-VSNDAGVANSKVPLTVV-PSETLKIKKG 4118

Human   727 ----TFTTSERVVLTCELSRVDFPATWYKDGQKVEESELL-VVKMDGRKHRLILPEAKVQDSGEF 786
                ..|...:::|:.|:........|||..:.|..|:.. :|::...:::|.:..|::.|:|.:
Worm  4119 LTDVNVTQGTKILLSVEVEGKPKTVKWYKGTETVTSSQTTKIVQVTESEYKLEIESAEMSDTGAY 4183

Human   787 E--CRTEGVSAFFGVTVQDPPVHIVDPREHV----FVHAITSECV----MLACEVDREDAP--VR 839
            .  ..|:..|.....||.     :....|.:    |...:..:.|    .|..||:.|..|  |:
Worm  4184 RVVLSTDSFSVESSATVT-----VTKAAEKISLPSFKKGLADQSVPKGTPLVLEVEIEGKPKDVK 4243

Human   840 WYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVAGDECAYF-TVTITDVSSWIVYPS 903
            |||:|.|:::.....|.| |.: ||.:|..|..|.||:...|.:|.... :....:||:.....|
Worm  4244 WYKNGDEIKDGKVEDLGN-GKY-RLTIPDFQEKDVGEYSVTAANEAGEIESKAKVNVSAKPEIVS 4306

Human   904 GKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEY 968
            |.|.....:.|......::..|...|:|.|:|:|:.:  |......|....|.:|..|:||:.:|
Worm  4307 GLVPTTVKQGETATFNVKVKGPVKGVKWYKNGKEIPD--AKTKDNGDGSYSLEIPNAQVEDAADY 4369

Human   969 LCEID------DESASFTVTVTEPPVRIIYPRDEVTLIAVTL---ECVVLMCELSREDAPVRWYK 1024
            ...:.      |.||:.||.:.:.....:.|.....||..|:   |......::......|:|||
Worm  4370 KVVVSNDAGDADSSAALTVKLADDGKDKVKPEIVSGLIPTTVKQGETATFNVKVKGPVKQVKWYK 4434

Human  1025 DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPA 1085
            :|.|:..::|  .:.......|.:|.||.:|..::..    ||||..:...:||..|...||
Worm  4435 NGKEIPNAKA--KDNGDGSYSLEIPNAQLDDTADYKVVVSNDAGDADSSAALTVKLPGIAIV--- 4494

Human  1086 ARSL-DLHFGAPGRVELRCEVAPAGSQVRWYKDGLEVEASDALQLGAEGPTR-TLTLPHAQPEDA 1148
             :.| |.......:..|:.|......:::|||:|.|:..||..|.|::|..: .|.:|.|..:||
Worm  4495 -KGLEDAEVPKGKKAVLQVETNKKPKEIKWYKNGKEITPSDKAQPGSDGDNKPQLVIPDAGDDDA 4558

Human  1149 GEYVCETRHE---------AITFNVILAEPPVQFLALETTPSPLCVAPGEPVVLSCELSRAGAPV 1204
            .||......|         |:|..:...||.: ...||..    .|:.|.|:.|..|.|.:...|
Worm  4559 AEYKVVLTDEDGNTADSSCALTVKLPAKEPKI-IKGLEDQ----VVSIGSPIKLEIETSGSPKTV 4618

Human  1205 VWSHNGR--PVQEGEGLELH-AEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSLSFTVQVAEPP 1266
            .|..||:  |....:.:::. .:..:.||.|.::.....|.|..:.....|:.:.|..:.| ||.
Worm  4619 KWYKNGKELPGAAAKTIKIQKIDDNKYVLEIPSSVVEDTGDYKVEVANEAGSANSSGKITV-EPK 4682

Human  1267 VRVVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQ-AGARQVLRVQG 1330
            :..:.|...|:   .|.|.:.|..|..:.....|:|||:|:.:....|..:|| ...:..|.::.
Worm  4683 ITFLKPLKDQS---ITEGENAEFSVETNTKPRIVKWYKNGQEIKPNSRFIIEQKTDTKYQLVIKN 4744

Human  1331 ARSGDAGEY------LCDAPQDSRIFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVSPPDAD 1389
            |...||..|      .....:.|....|...:..|.|:|..|....|.:|....|..::.....|
Worm  4745 AVRDDADTYKIVLENTAGEAESSAQLTVKKAKAGLCKIVKGLEDQVVAKGAKMVFEVKIQGEPED 4809

Human  1390 VTWLRNGAVVTPGPQ--VEMAQNGSSRILTLRGCQLGDAGTVTL----RAGSTATSARLHVRETE 1448
            |.|||:..|::.|..  :|...:.:.|:: :....|.|||..|:    .:|...:.|:..|.|..
Worm  4810 VRWLRDANVISAGANAIIEKIDDTTYRLI-IPSADLKDAGEYTVEVINESGKAKSDAKGEVDEKP 4873

Human  1449 LLFLRRLQDVRAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDG-HIHRLFIHGV 1512
            .: :|.|:::...||.|...:||..  .....|:|.:..|.:..:|.|...:.| ..:.|.|:..
Worm  4874 EI-VRGLENIEIPEGDDDVFKVEVS--APVRQVKWYKNDQEIKPNSHLEAKKIGPKKYELAINRA 4935

Human  1513 ILADQGTY---------GCESHHDRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQLELSQEGV 1568
            .|.|...|         .|:|    :.|...|:|..|:::..|:||.:.|  ....:|::..||:
Worm  4936 QLDDGADYKVVLSNAAGDCDS----SAALTVVKPNVLKIVDGLKDVDVEE--PQPVELKVKVEGI 4994

Human  1569 TG--EWARGGVQLYPG-------------------PKCHIHSDGHRHRLVL-NGLGLADSGCV-- 1609
            ..  :|.:.|.:|.|.                   |... .|||..:|:|| |..|...||.|
Worm  4995 PKVIKWYKNGQELKPDADGFKFEEKPESGEFSLTIPSSK-KSDGGAYRVVLGNDKGEVYSGSVVH 5058

Human  1610 --SFTADSLRCAARLIVREVPVTIVRGPHDLEVTEGDTATFECELS-QALADVTWEKDGNALTPS 1671
              |..:......|..:   .|:      .|.||.|||..|.:|.:: :...:|.|||||..|...
Worm  5059 VKSAKSSEPTSGANFL---SPL------KDTEVEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKD 5114

Human  1672 PRLRLQ-ALGTRRLLQLRRCGPSDAGTYSCA----VGTARAGPVRLTVRER-----TVAVLSELR 1726
            .|:.:: ||.....|::|....||.|.|...    .|:| ....::||.|:     ....:..|:
Worm  5115 DRITMRVALDGTATLRIRSAKKSDIGQYRVTAKNEAGSA-TSDCKVTVTEQGEQPSKPKFVIPLK 5178

Human  1727 SVSAREGDGATFECTVSEV-ETTGRWELGGRPLRPGARVRI--RQEGKKHILVLSELRAEDAGEV 1788
            :.:|..||...|...|..: :.|.:|.|.|.|::...|:.:  ..:| .:.|.:.::|.||.|.:
Worm  5179 TGAALPGDKKEFNVKVRGLPKPTLQWFLNGIPIKFDDRITLDDMADG-NYCLTIRDVREEDFGTL 5242

Human  1789 R---------------FQAGPAQSLALLEVEALPLQMCRHPPR------EKTVLVGRRAVLEVTV 1832
            :               ||.|........:       ..|:|||      ::.:.||....:|..|
Worm  5243 KCIAKNENGTDETVCEFQQGAGHDDGSRD-------DLRYPPRFNVPLWDRRIPVGDPMFIECHV 5300

Human  1833 -SRSGGHVCWLREGAELCPGDKYEMRSHGPTHSLV-------IHDVRPEDQGTYCCQA----GQD 1885
             :.....|.|.::      |.|.|..:|....:.|       |......|.|.|.|.|    ||.
Worm  5301 DANPTAEVEWFKD------GKKIEHTAHTEIRNTVDGACRIKIIPFEESDIGVYMCVAVNELGQA 5359

Human  1886 STHTRLLVE 1894
            .|.....||
Worm  5360 ETQATYQVE 5368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OBSL1	XP_011509159.1	IG_like	18..101	CDD:214653	28/93 (30%)
		IGc2	25..88	CDD:197706	19/73 (26%)
		IG	134..226	CDD:214652	29/91 (32%)
		IGc2	142..216	CDD:197706	23/73 (32%)
		IG	252..336	CDD:214652	27/84 (32%)
		Ig	252..336	CDD:299845	27/84 (32%)
		I-set	342..426	CDD:254352	29/92 (32%)
		Ig	358..421	CDD:143165	23/71 (32%)
		IG_like	435..510	CDD:214653	19/84 (23%)
		FN3	518..602	CDD:238020	23/122 (19%)
		IG	725..802	CDD:214652	16/86 (19%)
		Ig	734..802	CDD:143165	15/70 (21%)
		Ig	825..893	CDD:143165	24/74 (32%)
		Ig	916..984	CDD:143165	19/73 (26%)
		IG	1005..1074	CDD:214652	17/72 (24%)
		Ig	1007..1075	CDD:143165	17/71 (24%)
		IG_like	1097..1154	CDD:214653	19/57 (33%)
		IGc2	1099..1159	CDD:197706	20/69 (29%)
		Ig_Semaphorin_C	1178..1267	CDD:143180	21/91 (23%)
		IG	1180..1262	CDD:214652	18/84 (21%)
		IG	1282..1343	CDD:214652	17/67 (25%)
		IGc2	1283..1341	CDD:197706	16/64 (25%)
		I-set	1361..1444	CDD:254352	22/88 (25%)
		ig	1364..1430	CDD:278476	17/67 (25%)
		IG_like	1456..1535	CDD:214653	19/88 (22%)
		Ig	1481..1536	CDD:143165	14/64 (22%)
		I-set	1541..1624	CDD:254352	25/108 (23%)
		I-set	1631..1714	CDD:254352	26/88 (30%)
		Ig	1635..1724	CDD:299845	29/99 (29%)
		I-set	1725..1803	CDD:254352	21/95 (22%)
		Ig	1814..1893	CDD:299845	23/96 (24%)
		IG_like	1815..1893	CDD:214653	22/95 (23%)
unc-89	NP_001020985.1	SH3	65..124	CDD:302595
		RhoGEF	153..328	CDD:238091
		PH_unc89	341..455	CDD:270134
		Ig	568..634	CDD:143165
		I-set	<570..638	CDD:254352
		I-set	648..737	CDD:254352
		Ig	661..728	CDD:299845
		I-set	748..837	CDD:254352
		IGc2	761..827	CDD:197706
		I-set	844..935	CDD:254352
		I-set	946..1034	CDD:254352
		Ig	954..1034	CDD:299845
		I-set	1044..1133	CDD:254352
		Ig	<1060..1132	CDD:299845
		I-set	1140..1237	CDD:254352
		Ig	1146..1237	CDD:299845
		RCSD	1384..1491	CDD:282963
		RCSD	1481..1590	CDD:282963
		RCSD	1576..1678	CDD:282963
		RCSD	1735..1819	CDD:282963
		RCSD	1789..>1860	CDD:282963
		I-set	1982..2068	CDD:254352
		Ig	2009..2069	CDD:299845
		Ig_TrkABC_d4	2075..2164	CDD:143173
		I-set	2081..2164	CDD:254352
		I-set	2171..2262	CDD:254352
		Ig	<2198..2262	CDD:299845
		I-set	2269..2360	CDD:254352
		Ig	2270..2360	CDD:299845
		I-set	2367..2456	CDD:254352
		IGc2	2380..2446	CDD:197706
		I-set	2463..2554	CDD:254352
		Ig	2490..2554	CDD:299845
		I-set	2563..2652	CDD:254352
		Ig	2579..2647	CDD:143165
		I-set	2659..2747	CDD:254352
		Ig	2667..2747	CDD:299845
		I-set	2754..2843	CDD:254352
		Ig	2777..2841	CDD:143165
		I-set	2887..2981	CDD:254352
		Ig	2904..2978	CDD:143165
		I-set	2994..3082	CDD:254352
		IGc2	3009..3072	CDD:197706
		I-set	3087..3183	CDD:254352
		Ig	3101..3179	CDD:299845
		I-set	3189..3279	CDD:254352
		Ig	3206..3276	CDD:299845
		I-set	3286..3377	CDD:254352
		Ig	3303..3374	CDD:143165
		I-set	3384..3472	CDD:254352	29/96 (30%)
		Ig	3402..3472	CDD:143165	25/78 (32%)
		I-set	3482..3573	CDD:254352	33/120 (28%)
		Ig	3501..3570	CDD:143165	25/80 (31%)
		I-set	3580..3671	CDD:254352	30/103 (29%)
		IGc2	3593..3661	CDD:197706	22/67 (33%)
		I-set	3686..3776	CDD:254352	29/93 (31%)
		IGc2	3699..3766	CDD:197706	23/70 (33%)
		I-set	3817..3902	CDD:254352	21/89 (24%)
		Ig	3834..3899	CDD:143165	16/69 (23%)
		I-set	3920..4010	CDD:254352	18/101 (18%)
		Ig	3921..4010	CDD:299845	18/100 (18%)
		I-set	4018..4107	CDD:254352	26/114 (23%)
		Ig	4046..4107	CDD:299845	16/73 (22%)
		Ig	4108..4201	CDD:299845	17/93 (18%)
I-set	4114..4202	CDD:254352	17/92 (18%)
I-set	4212..4298	CDD:254352	25/87 (29%)
IGc2	4226..4288	CDD:197706	23/63 (37%)
I-set	4302..4388	CDD:254352	21/87 (24%)
Ig	4319..4384	CDD:143165	15/66 (23%)
I-set	4400..4486	CDD:254352	21/87 (24%)
Ig	4417..4482	CDD:143165	16/66 (24%)
I-set	4493..4581	CDD:254352	25/91 (27%)
Ig	4518..>4566	CDD:299845	17/47 (36%)
I-set	4588..4679	CDD:254352	21/95 (22%)
Ig	4599..4679	CDD:299845	18/79 (23%)
I-set	4685..4772	CDD:254352	20/89 (22%)
Ig	<4713..4772	CDD:299845	14/58 (24%)
I-set	4781..4869	CDD:254352	22/88 (25%)
Ig	4790..4869	CDD:299845	19/79 (24%)
I-set	4873..4962	CDD:254352	21/95 (22%)
Ig	4891..4960	CDD:299845	15/74 (20%)
I-set	4969..5059	CDD:254352	23/92 (25%)
Ig	4985..5051	CDD:143165	16/66 (24%)
I-set	5073..5161	CDD:254352	27/97 (28%)
Ig	5094..5161	CDD:299845	18/67 (27%)
I-set	5171..5260	CDD:254352	18/89 (20%)
Ig	5189..5255	CDD:143165	14/66 (21%)
I-set	5277..5367	CDD:254352	22/95 (23%)
IGc2	5291..5357	CDD:197706	16/71 (23%)
I-set	5383..5473	CDD:254352
IGc2	5397..5463	CDD:197706
I-set	5487..5577	CDD:254352
IGc2	5501..5567	CDD:197706
I-set	5595..5684	CDD:254352
Ig	5614..5681	CDD:143165
I-set	5701..5791	CDD:254352
IGc2	5714..5781	CDD:197706
I-set	5815..5905	CDD:254352
IGc2	5828..5895	CDD:197706
I-set	5925..6015	CDD:254352
Ig	5939..6015	CDD:299845
I-set	6038..6131	CDD:254352
Ig	6058..6126	CDD:143165
I-set	6150..6240	CDD:254352
Ig	6168..6237	CDD:143165
FN3	6275..6358	CDD:214495
IG_like	6413..6501	CDD:214653
Ig	6427..6499	CDD:143165
I-set	6507..6597	CDD:254352
Ig	6529..6594	CDD:143165
PK_Unc-89_rpt1	6620..6878	CDD:271011
S_TKc	6640..6878	CDD:214567
I-set	7528..7616	CDD:254352
Ig	7546..7616	CDD:299845
FN3	7621..7716	CDD:238020
STKc_Unc-89_rpt2	7781..8035	CDD:271014
S_TKc	7793..8035	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I7397
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8260
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100287
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.760