Protein Alignment PSD3 and Efa6

DIOPT Version :10

• Sequence 1: NP_001399795.1
• Gene: PSD3 / 23362
• HGNCID: 19093
• Length: 1175
• Species: Homo sapiens
• Sequence 2: NP_001163691.2
• Gene: Efa6 / 42665
• FlyBaseID: FBgn0051158
• Length: 1601
• Species: Drosophila melanogaster
• Alignment Length: 1265
• Identity: 362/1265 - (28%)
• Similarity: 534/1265 - (42%)
• Gaps: 332/1265 - (26%)

Human     3 DESSSPSMGWKHWPVTSATQDLWGMDPRC--------RDALGCSPPRAVLVHAADGAERTVLRRG 59
            ::.|:.|:|     ..||.|.|..:..|.        |||:.|:.      .:..|:..|.::..
  Fly   555 EDYSTNSLG-----SGSAKQRLRALKQRTATRQQQRNRDAVDCAG------RSGSGSSSTTVKSE 608

Human    60 AETCQILPRSCKEATGTTAQATRAWLYRYCPAV--HTSKGCPAPPATLPLKAETFVWVNNASAHS 122
            |....:...|....|...:.:|        |.:  .|:...|..|....|..|     :::.|.:
  Fly   609 AGGLGLDETSFSVPTSPISLST--------PLIDKETANSVPTSPEPSSLVPE-----SSSGAGA 660

Human   123 QSVAKAKYE-----------FLFGRSEGKAPDTSDHGGSTLLPPNVTNEFPEYGTMEEGGEGLRA 176
            .:|...::.           |...:||.........|.:.::|.::.         |:....|..
  Fly   661 GAVVVRRHNGHVVRKCDAAGFRTSKSEDHLQQIQREGIAAVIPIDID---------EDVNSSLNT 716

Human   177 SLEFDGEALPCHPQEQQGVQPLTGCHSGLDS-VTEGPK-DVREAPSQSHLKEQSL------QPID 233
            .|:...::     ::.|.:..:...:|.|.| ..||.: |.|.:.|.|:..:.:.      :|..
  Fly   717 LLDTRQDS-----EDSQSMATVIVNNSSLASNNNEGEQTDNRSSSSSSNSSDNNNCSSNTGEPAT 776

Human   234 SLISALKATEARIISGTLQAT-------------KVLDQD-AVSSFSVQQVEKELDTASRKTQRV 284
            |..:...||   ||:.|...|             |..|:| .|.:::......:|....|:.|:.
  Fly   777 SETATATAT---IITATSTRTMNCSSKLNYILCKKASDRDRIVWTYNAPLQPHQLAALQRQQQQQ 838

Human   285 NKTLPAGQKNLPEIPLSAEVTTEESFYLSIQKDLTALLTGDTQAEI--SQIMNNGRKGAV----- 342
            .:.....|:.|.:..|..:...::......|:.     ....|.::  .|..:|....::
  Fly   839 EQQFQQQQQQLHQQHLQQQQQLQQQHQQQQQQQ-----QQQQQQQLYGQQSHSNSHSSSISSSPQ 898

Human   343 --CVQEPSCPLASLGSSAVTCHSAGSVGFL------------KEQRSALGREH------------ 381
              .|..|:.| .|:.||.::  |:||.|.|            .:|:....||.
  Fly   899 HSAVGSPASP-TSVSSSVMS--SSGSKGALGLGSSSNGPMAAVQQQQLREREQGGQVAQPPSGIP 960

Human   382 ------PGGCDRSSSMGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFETSLQRTASPDSKESSK 440
                  .|||..:...|..|               ||...:.    ....::...:|||.::..
  Fly   961 GLLSCPGGGCGNNGGGGGIG---------------GGGNNDQ----SVSEAISNISSPDYQDDD- 1005

Human   441 VPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQENKQHL--- 502
               :|:||..:.....|::         ||:...|       :.:.::...:  .|:.||.|
  Fly  1006 ---NLLSSRDILGGMVLSD---------PSDSDST-------ILVSDAAAHQ--RQQLKQQLRAQ 1049

Human   503 -EKTPKPERDRERISEQEEH-----VKGEDEDILGPGYTEDSTDVYSSQFETILDNTSLYYSAES 561
             ::..:.||||:|..||.||     |:|.|.:..|...|...                   |.|.
  Fly  1050 QQQQRERERDRDRDREQSEHKVVIQVRGLDSNSSGGNGTNGR-------------------SEED 1095

Human   562 LETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSGGGHQDILSVSADGGIVMGYSSGVTNGL 626
            :.||..||                                              :|   .:|.|:
  Fly  1096 VVTLTDEP----------------------------------------------LG---TMTVGM 1111

Human   627 NDASDSIYTKGTPEIAFWGSNAGVKTTRLEAHSEMGSTEILEKETPENLSNGTSSNVEAAKRLAK 691
            .|||        |.::..||:..      ..||...|.:.::              :.:|.||||
  Fly  1112 RDAS--------PPVSDDGSDVE------SLHSYHYSPKAVD--------------MPSAIRLAK 1148

Human   692 RLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERV 756
            ||:.||.||:|||::||.|||:||:.||:||||.|.|...:|||:||.|.:.|||.|||||||||
  Fly  1149 RLHSLDGFKKSDVSRHLSKNNDFSRAVADEYLKHFTFEKKSLDQALREFLQQFSLSGETQERERV 1213

Human   757 LIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSK 821
            |:|||.|:..|||.|..|||.||.||||||||||||||.||.:||:|.||:.||..:|:|.:|.|
  Fly  1214 LVHFSKRFLDCNPGTFNSQDAVHTLTCAIMLLNTDLHGQNINRKMSCAEFVDNLADLNDGENFPK 1278

Human   822 DLLKVKLSQFFSSLVFGHHYFRISTCSSALAALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANG 886
            |:||                           :||.:||.:.||||:|:|     ..:..:::||.
  Fly  1279 DVLK---------------------------SLYQAIKTKPLEWALDEE-----AGDLQQQRANN 1311

Human   887 THPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVL 951
            :   .:..:|  .|||||.|....|..||.|::.||...|...||||.|||.||.||..|:..||
  Fly  1312 S---ALGNVG--LNPFLDPPELATAVEYKKGYVMRKCCYDSSFKKTPFGKRSWKMFYCTLRDLVL 1371

Human   952 YLQKDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGW 1016
            ||.|||:...|:...::|.||:.:|||||:||.||.||.:||:|:|||....||||...:|:|.|
  Fly  1372 YLHKDEHGFRKSQMSDNLHNAIRIHHALATKANDYTKKQHVFRLQTADQAEYLFQTSDSKELQSW 1436

Human  1017 INKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYP 1081
            :..||.|.|..||||....:||||:|.|||||:..:||..:|||.|||.:|.|:..||.||:..|
  Fly  1437 VETINYVCAAISAPPLEGGVGSQKRFQRPLLPSKQSKLMLKEQLDSHEVQLAQLDQELNEHKKGP 1501

Human  1082 PDKKVKAKDVDEYKLKDHYLEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNPDT 1146
            ...|..|  :..||.|:.||::|..||..|||||  ..|.|....:.|....:.|.:|.....||
  Fly  1502 IPSKGLA--LQNYKEKESYLQYELRRYRTYVSIL--SAKMLADQQQLELQAQQPSPASHEEEADT 1562

Human  1147 SPI--TAKVKRNVSERKDHRPETP-SIKQK 1173
            .|:  ||..           |.|| ||.||
  Fly  1563 FPVGTTACT-----------PPTPQSINQK 1581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSD3	NP_001399795.1	Sec7	682..863	CDD:238100	95/180 (53%)
		PH_EFA6	908..1033	CDD:270107	62/124 (50%)
Efa6	NP_001163691.2	PDZ_canonical	6..85	CDD:467153
		PHA03269	225..>344	CDD:165527
		Sec7	1124..1293	CDD:238100	98/215 (46%)
		PH_EFA6	1330..1452	CDD:270107	61/121 (50%)