Protein Alignment PSD3 and efa-6

DIOPT Version :10

• Sequence 1: NP_001399795.1
• Gene: PSD3 / 23362
• HGNCID: 19093
• Length: 1175
• Species: Homo sapiens
• Sequence 2: NP_502416.1
• Gene: efa-6 / 178217
• WormBaseID: WBGene00013223
• Length: 818
• Species: Caenorhabditis elegans
• Alignment Length: 864
• Identity: 243/864 - (28%)
• Similarity: 377/864 - (43%)
• Gaps: 193/864 - (22%)

Human   377 LGREHPGGCDRSSS-----MGRPGRVKHVEFQGVEILWTGGDKRETQHPIDFETS-LQRTAS--- 432
            ||.:.|.|...:||     :.|......|.|..:........|. ::.|:...|| ::|..|
 Worm    52 LGDQLPPGTTVASSIHPHQLSRATASAGVSFPSMNRNGAAAQKL-SRLPVPVSTSQIERRGSLAR 115

Human   433 PDSKESSKVPRHLISSAGLCNSSSLTENVWDESWKAPSERPGTSSGTFSPVRLDESGEDEVFLQE 497
            ..|:|||.....::.:                   ||.||..::.       ::||.|:.|.:..
 Worm   116 KTSEESSPTAIRMLKT-------------------APIERMESTD-------VEESEEETVMMTT 154

Human   498 NKQHLEKTPKPERDRERISEQEEHV------KGEDEDILGPGYTEDSTDVYSSQFETILDN-TSL 555
            :::..:|.|....|...:.::|:.:      |..:|:|:       :..:.|:.|....|| ...
 Worm   155 DEKENQKKPNENDDEVMVVDEEQFIVVSNDMKSPNEEIV-------AKSLRSAMFTMPTDNHHHS 212

Human   556 YYSAESLETL----------------YSEPDSYFSFEMPLTPMI----QQRIKEGGQFLERTSGG 600
            |.|:..:.||                |.:.|...:..:....|.    ||..:....:.|:.:..
 Worm   213 YNSSPQISTLSPHLRSNGDGPSRSPVYDDVDDDLNGSLDAKDMSNNSHQQSFRSPENYSEKDTPS 277

Human   601 GHQDILSVSADGGIVMGYSSGVTN----------------------GLNDASDSIY-TKGTPEIA 642
            .|.   .|:.||       |||:|                      |.......|: ::.||..|
 Worm   278 KHS---VVTIDG-------SGVSNHYDQDGMFSHVYYSTQDTTPKHGSPSLRKQIFESRTTPNTA 332

Human   643 FWGSNAGVKTTRLEAHSE------------MGSTEILEKETPENLSNGTSSNVEAAKRLAKRLYQ 695
            ...|:|....: |.|.||            ..|:.:.:...|...:|......||| ::|:.||:
 Worm   333 ASNSSASASPS-LHATSESRGATGGVSLRSAESSNLNQTAVPSTSTNSVGGEREAA-QIARNLYE 395

Human   696 LDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSLVGETQERERVLIHF 760
            |.....:.||..|.:.||||.|:..:||:.|.|:...:|.:||.|.....|.||:..|||:|..|
 Worm   396 LKNCTSTQVADRLNEQNEFSFLILVKYLELFQFSTTRIDAALREFLSRVELRGESSARERLLRVF 460

Human   761 SNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEFIANLQGVNEGVDFSKDLLK 825
            |.||..|||....|.|.||.||||::|||:||||.|:|||||.::||.|:  .:.|..|.:::||
 Worm   461 SARYLECNPAIFDSLDEVHTLTCALLLLNSDLHGPNMGKKMTARDFITNI--AHTGCTFKREMLK 523

Human   826 VKLSQFFSSLVFGHHYFRISTCSSALAALYNSIKNEKLEWAVDDEEKKKSPSESTEEKANGTHPK 890
                                       .|:.|||:..:       ..:.|...||   |||:...
 Worm   524 ---------------------------TLFQSIKDNAI-------SLQNSAKNST---ANGSVAS 551

Human   891 TISRIGSTTNPFLDIPHDPNAAV-YKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQ 954
            |     |...|......||::.| |.||||.||...:.||.|||.|:|.|:..||.|:|.|||..
 Worm   552 T-----SRRQPQQIYEVDPDSVVEYYSGFLMRKYVRETDGGKTPFGRRSWRMVYARLRGLVLYFD 611

Human   955 KDEYKPEKALSEEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINK 1019
            .||: |:.......|:||||:|||||..|.||:||..||:::.|....:||||.:.:|:|.|..|
 Worm   612 TDEH-PKATSRYASLENAVSLHHALAEPAPDYKKKSFVFRVRIAHGGEILFQTSNQKELQEWCEK 675

Human  1020 INCVAAVFSAPPFPAAIGSQKKFS-RPLLPATTTKLSQEEQLKSHESKLKQITTELAE--HRSYP 1081
            ||.|||.||:|..|..:.|:.:.: .|.||.........:||.:||:::.:: .|:.|  .:|..
 Worm   676 INFVAAAFSSPTLPLPVTSKPETAPMPRLPRIPCLAPITKQLSTHEARVAEL-NEMIEIVSQSVS 739

Human  1082 PDKKVKAKDVDEYKLKDHY--LEFEKTRYEMYVSILKEGGKELLSNDESEAAGLKKSHSSPSLNP 1144
            |::       .:..:.|.:  |.|||.||..|:::|:.         ..||   :|:.|:.::|.
 Worm   740 PNQ-------PQQLITDRWVLLSFEKRRYSTYINVLRR---------SLEA---RKASSATTMNI 785

Human  1145 DTSPITAKVKRN----VSE 1159
            ..:| |.:.::|    |||
 Worm   786 MMTP-TRRQQQNQKPVVSE 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PSD3	NP_001399795.1	Sec7	682..863	CDD:238100	69/180 (38%)
		PH_EFA6	908..1033	CDD:270107	62/125 (50%)
efa-6	NP_502416.1	Sec7	350..534	CDD:214569	72/213 (34%)
		PH_EFA6	565..689	CDD:270107	61/124 (49%)