DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF629 and CG6689

DIOPT Version :9

Sequence 1:	NP_001073886.1	Gene:	ZNF629 / 23361	HGNCID:	29008	Length:	869	Species:	Homo sapiens
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	112/443 - (25%)
Similarity:	166/443 - (37%)	Gaps:	129/443 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    13 QGPEQSPNDAHRGAESENEEESPRQESSGEEI---IMGDPAQSPESKDSTEMSLERSSQDP-SVP 73
            :.|..|.:|.....|:.|.||.  :::.|:.:   ...|...|.|:.|  |::...::||| ||
  Fly   255 ENPISSDHDLISDTENTNVEEI--EDAGGDHVEDEATSDDQTSQEAVD--EVAESPAAQDPLSV- 314

Human    74 QNPPTPLG---HSNPLDHQIPLDPPAPEVVPTPSDWTKACEASWQWGALTTWNSPPVVPANEPSL 135
                 .||   ....||                 .:|...:|..:.||       |:  |::|..
  Fly   315 -----ALGAKIFKELLD-----------------QYTGKEKARLRKGA-------PI--ASKPKA 348

Human   136 RELVQGRPAGAEKPYICNECGKSFSQWSKLLRHQRIHTGERPNTCSECGKSFTQSSHLVQHQRTH 200
            :|    :.||.:||                      .....|.|..|        .:|::..:..
  Fly   349 KE----KAAGEQKP----------------------KRSANPKTKEE--------RNLIRRAQLR 379

Human   201 TGEKPYKCPDCGKCFSWSSNLVQHQRTHTGEKPYKCTECEKAFTQSTNLIKHQR-SHTGEKPYKC 264
            .....:.|..||:.|..|.||..|...||..|.|:||||.|.|..:.....|.| .|.||.|:.|
  Fly   380 AKPPNFVCDQCGQAFRMSHNLRIHMLRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFAC 444

Human   265 GECRRAFYRSSDLIQHQA-THTG--------------EKP-----YKCPECGKRFGQNHNLLKHQ 309
            |.|...|.......:|:: .|..              .||     |:|..|.|.:...:.|..|.
  Fly   445 GFCSETFAYPGARQKHESEVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHI 509

Human   310 KIHAGEKPYRCTECGKSFIQSSELTQHQRTHTGEKPYECLECGKSFGHSSTLIKHQRTHLREDPF 374
            |.|.....|:|..|.||:...::|.:|:.||. ::|.:|..|.|.|        :|||.|||
  Fly   510 KSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGF--------YQRTRLRE--- 562

Human   375 KCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLINH--QRIHR 425
                             |:..|||||||.|..|..:|....|:.:|  .::|:
  Fly   563 -----------------HELIHTGERPYWCEVCNVNFRYKYNMKSHANSKMHQ 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF629	NP_001073886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105		22/98 (22%)
		COG5048	146..521	CDD:227381	80/303 (26%)
		zf-C2H2	150..172	CDD:278523	0/21 (0%)
		C2H2 Zn finger	152..172	CDD:275368	0/19 (0%)
		zf-C2H2	179..200	CDD:278523	3/20 (15%)
		C2H2 Zn finger	180..200	CDD:275368	2/19 (11%)
		zf-H2C2_2	192..216	CDD:290200	4/23 (17%)
		C2H2 Zn finger	208..228	CDD:275368	8/19 (42%)
		zf-H2C2_2	220..245	CDD:290200	13/24 (54%)
		C2H2 Zn finger	236..256	CDD:275368	8/20 (40%)
		zf-H2C2_2	248..273	CDD:290200	10/25 (40%)
		C2H2 Zn finger	264..284	CDD:275368	5/20 (25%)
		zf-H2C2_2	276..299	CDD:290200	8/42 (19%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		zf-H2C2_2	304..329	CDD:290200	9/24 (38%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		zf-H2C2_2	332..355	CDD:290200	8/22 (36%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		zf-H2C2_2	361..384	CDD:290200	6/22 (27%)
		C2H2 Zn finger	376..396	CDD:275368	1/19 (5%)
		zf-H2C2_2	389..412	CDD:290200	10/22 (45%)
		zf-C2H2	402..424	CDD:278523	6/23 (26%)
		C2H2 Zn finger	404..424	CDD:275368	5/21 (24%)
		zf-H2C2_2	416..439	CDD:290200	3/12 (25%)
		C2H2 Zn finger	432..452	CDD:275368
		zf-H2C2_2	445..469	CDD:290200
		C2H2 Zn finger	460..480	CDD:275368
		zf-H2C2_2	472..497	CDD:290200
		C2H2 Zn finger	488..508	CDD:275368
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..651
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..837
		C2H2 Zn finger	844..864	CDD:275368
CG6689	NP_650051.1	THAP	2..96	CDD:283206
		zf-AD	167..240	CDD:214871
		zf-C2H2	385..407	CDD:278523	8/21 (38%)
		C2H2 Zn finger	387..407	CDD:275368	8/19 (42%)
		zf-H2C2_2	399..422	CDD:290200	12/22 (55%)
		C2H2 Zn finger	415..436	CDD:275368	8/20 (40%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	6/19 (32%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	547..567	CDD:275368	11/47 (23%)
		zf-met	574..597	CDD:289631	5/22 (23%)
		C2H2 Zn finger	575..591	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010