DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF629 and CG11247

DIOPT Version :9

Sequence 1:	NP_001073886.1	Gene:	ZNF629 / 23361	HGNCID:	29008	Length:	869	Species:	Homo sapiens
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	125/424 - (29%)
Similarity:	177/424 - (41%)	Gaps:	70/424 - (16%)

- Green bases have known domain annotations that are detailed below.

Human   123 NSPPVVPANEP--------------SLRELV-------QGRPAGAEKPYICNECGKSFSQWSKLL 166
            :|||....:.|              |||:..       .|.....:..|:..:..||..:...:.
  Fly    25 SSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVK 89

Human   167 RHQRIHTGERPNTCSECGKSFTQSSHLVQHQRTHTGEKPYKCPDCGKCFSWSSNLVQHQRT-HTG 230
            |...:        ||:|.|.|...:.|.:|...|:.|:|:||.||||.:..:.||..|..| |..
  Fly    90 RKHHV--------CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEH 146

Human   231 EKPYKCTECEKAFTQSTNLIKHQRSHTGEKPYKCGECRRAFYRSSDLIQHQATH--TGEKPYKCP 293
            .|.:.|::|.|:|.....|..|.|.|:|||||.|..|.:.|.|...|.||..:|  |..:.:.|.
  Fly   147 RKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCT 211

Human   294 ECGKRFGQNHNLLKHQKIHAGEKPYRCTECGKSFIQSSELTQHQRTHTGEKPYECLECGKSFGHS 358
            :|...|..|.||..|.:.|.....:||:.|...|.....|    |.|..::
  Fly   212 KCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQE-------------- 258

Human   359 STLIKHQRTHLREDPFKCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLINHQRI 423
                     |.:...|:|.:|.|.......|..|.:.||..:.:.|..|...|:..|....|.|:
  Fly   259 ---------HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRM 314

Human   424 HRGERPYICADCGKSFIMSSTLIRHQRIHTGEKPYKCSDCGK--SFIRSSHLIQH-RRTHTGEKP 485
            |.|||||.|..|.::|..||.|..|.|.||||||::|..|..  :|.:.:||..| ::.|..:||
  Fly   315 HTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKP 379

Human   486 YKCPECGKSFSQSSNLITHVRTHMDENLFVCSDC 519
            |.|..|...|.....|.:||. |       |:.|
  Fly   380 YMCEGCHDFFKIKVELQSHVE-H-------CAKC 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF629	NP_001073886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105
		COG5048	146..521	CDD:227381	117/380 (31%)
		zf-C2H2	150..172	CDD:278523	4/21 (19%)
		C2H2 Zn finger	152..172	CDD:275368	3/19 (16%)
		zf-C2H2	179..200	CDD:278523	7/20 (35%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		zf-H2C2_2	192..216	CDD:290200	11/23 (48%)
		C2H2 Zn finger	208..228	CDD:275368	9/20 (45%)
		zf-H2C2_2	220..245	CDD:290200	10/25 (40%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	248..273	CDD:290200	12/24 (50%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-H2C2_2	276..299	CDD:290200	7/24 (29%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..329	CDD:290200	8/24 (33%)
		C2H2 Zn finger	320..340	CDD:275368	5/19 (26%)
		zf-H2C2_2	332..355	CDD:290200	3/22 (14%)
		C2H2 Zn finger	348..368	CDD:275368	0/19 (0%)
		zf-H2C2_2	361..384	CDD:290200	5/22 (23%)
		C2H2 Zn finger	376..396	CDD:275368	5/19 (26%)
		zf-H2C2_2	389..412	CDD:290200	6/22 (27%)
		zf-C2H2	402..424	CDD:278523	6/21 (29%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		zf-H2C2_2	416..439	CDD:290200	10/22 (45%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		zf-H2C2_2	445..469	CDD:290200	12/25 (48%)
		C2H2 Zn finger	460..480	CDD:275368	6/22 (27%)
		zf-H2C2_2	472..497	CDD:290200	10/25 (40%)
		C2H2 Zn finger	488..508	CDD:275368	6/19 (32%)
		C2H2 Zn finger	516..536	CDD:275368	2/4 (50%)
		C2H2 Zn finger	571..591	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..651
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..837
		C2H2 Zn finger	844..864	CDD:275368
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/166 (34%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/203 (30%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/48 (13%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910