DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF629 and F57C9.4

DIOPT Version :9

Sequence 1:	NP_001073886.1	Gene:	ZNF629 / 23361	HGNCID:	29008	Length:	869	Species:	Homo sapiens
Sequence 2:	NP_491459.1	Gene:	F57C9.4 / 172100	WormBaseID:	WBGene00019011	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	209	Identity:	59/209 - (28%)
Similarity:	90/209 - (43%)	Gaps:	44/209 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   308 HQKIHAGEKPYRCTECGKSFIQSSELTQHQRTHTGEKPYE-CLECGKSFGHSSTLIKHQR----- 366
            |.|:..|::     :.|...:::|...|:|:. .|...|. |..|.:....|..|...::
Worm   680 HIKMENGKE-----QSGPLLLRNSPNDQNQKV-VGVVQYVICQLCPEEEQKSMDLSNQKQMEEHF 738

Human   367 --THLREDPFKCPVCGKTFTLSATLLRHQRTHTGERPYKCPECGKSFSVSSNLINHQRIHRGERP 429
              .|:.::..||..|.........:.:|.|.||.. .:.|..|||               ||.|.
Worm   739 LNKHVDKEKKKCEACPSDQFQPHNIGQHYRLHTNS-VFACEHCGK---------------RGRRN 787

Human   430 YICADCGKSFIMSSTLIRHQRIHTGEKPYKCSDCGKSFIRSSHLIQHRRTHTGEKPYKCPECGKS 494
            :              |..|.|.||||:||:|..|.|||..:|.|.:|...|||||.|:||.||::
Worm   788 F--------------LKTHIRTHTGERPYRCDTCSKSFTDASTLRRHGLVHTGEKKYQCPVCGRA 838

Human   495 FSQSSNLITHVRTH 508
            .::..|:..|:|:|
Worm   839 IARKDNVKAHIRSH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF629	NP_001073886.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..105
		COG5048	146..521	CDD:227381	59/209 (28%)
		zf-C2H2	150..172	CDD:278523
		C2H2 Zn finger	152..172	CDD:275368
		zf-C2H2	179..200	CDD:278523
		C2H2 Zn finger	180..200	CDD:275368
		zf-H2C2_2	192..216	CDD:290200
		C2H2 Zn finger	208..228	CDD:275368
		zf-H2C2_2	220..245	CDD:290200
		C2H2 Zn finger	236..256	CDD:275368
		zf-H2C2_2	248..273	CDD:290200
		C2H2 Zn finger	264..284	CDD:275368
		zf-H2C2_2	276..299	CDD:290200
		C2H2 Zn finger	292..312	CDD:275368	2/3 (67%)
		zf-H2C2_2	304..329	CDD:290200	4/20 (20%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		zf-H2C2_2	332..355	CDD:290200	6/23 (26%)
		C2H2 Zn finger	348..368	CDD:275368	4/26 (15%)
		zf-H2C2_2	361..384	CDD:290200	5/29 (17%)
		C2H2 Zn finger	376..396	CDD:275368	4/19 (21%)
		zf-H2C2_2	389..412	CDD:290200	8/22 (36%)
		zf-C2H2	402..424	CDD:278523	4/21 (19%)
		C2H2 Zn finger	404..424	CDD:275368	4/19 (21%)
		zf-H2C2_2	416..439	CDD:290200	3/22 (14%)
		C2H2 Zn finger	432..452	CDD:275368	3/19 (16%)
		zf-H2C2_2	445..469	CDD:290200	14/23 (61%)
		C2H2 Zn finger	460..480	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..497	CDD:290200	12/24 (50%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368
		C2H2 Zn finger	571..591	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	607..651
		C2H2 Zn finger	664..684	CDD:275368
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..837
		C2H2 Zn finger	844..864	CDD:275368
F57C9.4	NP_491459.1	C2H2 Zn finger	750..770	CDD:275368	4/19 (21%)
		C2H2 Zn finger	777..796	CDD:275368	10/47 (21%)
		zf-H2C2_2	789..812	CDD:290200	13/22 (59%)
		zf-C2H2	802..824	CDD:278523	9/21 (43%)
		C2H2 Zn finger	804..824	CDD:275368	8/19 (42%)
		zf-C2H2	830..852	CDD:278523	8/21 (38%)
		C2H2 Zn finger	832..852	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910