Protein Alignment ANGEL1 and cu

DIOPT Version :10

• Sequence 1: NP_001357675.1
• Gene: ANGEL1 / 23357
• HGNCID: 19961
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_001097746.1
• Gene: cu / 41339
• FlyBaseID: FBgn0261808
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 127/553 - (22%)
• Similarity: 193/553 - (34%)
• Gaps: 195/553 - (35%)

Human    11 LPATRLFRAL-SDAFFTCRKNV---LLANSSSPQVEGDFAMAPRGPEQE--------ECEGLL-- 61
            :|.|.|...| |:.....|.::   ||.:...|.........|..|.:|        |.:|.|
  Fly    24 MPVTALLLNLESNPLDYSRNDIGAELLEDDDKPPQLFSVTDEPPSPNEEDYKPPNHHEDDGKLAG 88

Human    62 QQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNP-----------------------GEENA 103
            ::.||...|..|.|| .|.|||:..|.:.:...:..|                       .|..|
  Fly    89 ERHREIPCSNCLKTA-PGHLIDRQSAINEMCQRLCGPECRRPQGLTLDGVRQDFLRQYEIAEAVA 152

Human   104 ASEDRWSSRQLSDLRAAENLD-EPFPEM--------------LGEEPLLEVEGV----------- 142
            .:....|:.|:....||..|: |...||              ||:...:...|:
  Fly   153 KTSAMTSTVQMKQRLAARKLEFEKEMEMDEQLGVASPRNDINLGQSSTVAATGMGEFEFEPPRDL 217

Human   143 ------EGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFE 201
                  .||..:|..:.:.....|...||.| |:|      ||:|                   :
  Fly   218 LLYLVRMGSFNSAPKINNVDSQDDGLVLPSG-LST------PALL-------------------Q 256

Human   202 GLGQLQPPAVEIPYHEILWREW-------EDFSTQPDAQGLKA---------------GDGPQFQ 244
            .:.||:...:|.|  .:|.|.:       ||.     |.||:.               ||    .
  Fly   257 HVQQLRGGGIEQP--SLLTRGFLKPLLADEDV-----ADGLRCLKLNSVSRVCSAPVEGD----D 310

Human   245 FTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLE 309
            ..|:.:|||:|.| .|.::.::.|..:.|.|.:|...::||.....||::|||||  ||: :.|:
  Fly   311 IRLLQWNILSQTL-GQHNDGFVRCPEEALTWEHRKYLIVQEILQNQPDVICLQEV--DHF-KFLQ 371

Human   310 PSLRMMGFT----------CFY-KRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDN 363
            ..|....:.          |.| ::..|  .||||:.||               |..|:|...|.
  Fly   372 TVLGSQNYAGIFFPKPDSPCLYIEQNNG--PDGCAIFYK---------------RDKLQLQGYDT 419

Human   364 VGL-VLLLQPLVPEGLGQVSVA----------PLCVANTHILYNPRRGDVKLAQMAILLAEV--- 414
            ..| |..:|.      .||::|          ..|||.||:          .|:...|||::
  Fly   420 RILEVWRVQS------NQVAIAARLRMRSSGREFCVATTHL----------KARHGALLAKLRNE 468

Human   415 ---DKVARLSD-GSHCPIILCGDLNSVPDSPLY 443
               |.:..:.. ....|::||||.|:.|..|:|
  Fly   469 QGRDLIRFVKQFAGDTPLLLCGDFNAEPVEPIY 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANGEL1	NP_001357675.1	EEP	248..>449	CDD:469791	61/225 (27%)
cu	NP_001097746.1	EEP	312..609	CDD:469791	62/227 (27%)