DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SYNE1 and shot

DIOPT Version :9

Sequence 1:XP_006715470.1 Gene:SYNE1 / 23345 HGNCID:17089 Length:8846 Species:Homo sapiens
Sequence 2:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster


Alignment Length:10060 Identity:1855/10060 - (18%)
Similarity:3514/10060 - (34%) Gaps:2981/10060 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   149 LPQLQSLSSS-----ASSVDSIVSSETPSPPSKRKVTTKIQG-----NAKKALLKWVQYTAGKQT 203
            ||..:.:.||     .:...:|.||.|    .:|:::..:.|     :|::|||:|.:.:..:..
  Fly   180 LPPAKMIRSSELEYRRALPPAIESSST----QRREISDIVVGKEDNVSAREALLRWARRSTARYP 240

Human   204 GIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDV 268
            |:.|.||..|||.|:||.:::|..||:|:|....:....||.||.||.|.|.|.|:.||||||||
  Fly   241 GVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAFHIVEKEYGVTRLLDPEDV 305

Human   269 DVDKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVW 333
            |.::|||||::||::...                 ::.|..||                      
  Fly   306 DTNEPDEKSLITYISSLY-----------------DVFPEPPS---------------------- 331

Human   334 IEQFERDLTRAQMVESNLQDKYQSFKHFRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDR 398
                                                      |.|                    
  Fly   332 ------------------------------------------IHP-------------------- 334

Human   399 VTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQRKLEQHKDLLQNT 463
                |||...|                             ::|||                    
  Fly   335 ----LFDMESQ-----------------------------RRVHE-------------------- 346

Human   464 DAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEF----LELKYRLLSLLV 524
                      ||               |:|::|.:.......:|.:..|    :|:| ||||   
  Fly   347 ----------YR---------------DLAQQFIYWCREKTAYLQERSFPPTLIEMK-RLLS--- 382

Human   525 LAESKLKSWIIKYGRRESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAEN 589
                                 .||.:.|                                     
  Fly   383 ---------------------DLQRFRS------------------------------------- 389

Human   590 VMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVASLQAWLEDAEKMLNQSENAKKDFF 654
                 :|.:|:.|.        :|.|.::....:||..||..:..   :||...:..|.|     
  Fly   390 -----DEVSARKRE--------KSKLIQIYKELERYFETVGEVDV---EAELRPDAIEKA----- 433

Human   655 RNLPHWIQQHTAMNDAGNFL---IETCDEM------VSRDLK---QQLLLLNGRWRELFMEVKQY 707
                 |.:.:||:.|....|   ||..:.:      |.|::|   |:|..|.||..|....:::.
  Fly   434 -----WYRMNTALQDREVILQQEIERLERLQRLADKVQREIKHVDQKLTDLEGRIGEEGRRIERL 493

Human   708 AQADEMDRMKKEYTDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKI 772
            ...|.                       |.:.|.||..       |:.||:     |:.|     
  Fly   494 HPVDA-----------------------KSIVEALETE-------IRHLEE-----PIQD----- 518

Human   773 ITKTAHLITKESPQEEGK-----EMFATMSKLKEQLTKVK-ECYSPLLYESQQLLIPLEE--LEK 829
            :.:..|::      .||:     |:...::||.::..::: ..::.|:.:...|..|:.|  :.:
  Fly   519 MNQDCHVL------NEGRYPHVSELHKKVNKLHQRWAQLRTNFHTNLVQKLSGLKYPVHETTVTR 577

Human   830 QMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSN 894
            |.....:|            |:..::..|:...:.:..||...|:.|. .:.||.       |.:
  Fly   578 QTRMVVES------------RQIDTNPHFRDLQEHIEWCQNKLKQLLA-ADYGSD-------LPS 622

Human   895 VLKHFDQTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEE 959
            |.:..|:.:.:.:|.|     |...|...|.::..:.:...:..:::...:|:||.         
  Fly   623 VKEELDRQQHEHKIID-----QFHTKILNDERQQTKFSGDELALYQQRLNQLQKVY--------- 673

Human   960 KGDPEELLRRHTEFFSQLDQRVLNAFLKACDELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAP- 1023
                .|||...|:..|.||.  |..||.........|.|:||.       ::.:.|.|.|.:.| 
  Fly   674 ----AELLSTSTKRLSDLDS--LQHFLGQASAELQWLNEKEQV-------EITRDWADKQLDLPS 725

Human  1024 ----YHLLHLKIDVEKNRFLASVEECRTELDR-ETKLMPQEGSEKIIKEHRVFFSDKGPHHLCEK 1083
                |..|..:::..:..|       .|.||| |..|..|..:.|.|:.|......:...     
  Fly   726 VHRYYENLMSELEKREMHF-------ATILDRGEALLNQQHPASKCIEAHLTALQQQWAW----- 778

Human  1084 RLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKL---MEDPDKW---KD--YTSRF 1140
            .|||  .||:::.::          |.|          .|.:.   ::|.::|   :|  ..|:|
  Fly   779 LLQL--TLCLEVHLK----------HAT----------EYHQFFGEIKDAEQWLAKRDEILNSKF 821

Human  1141 SEFSSWISTNETQLKGIKGEAIDTANHGEVKRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSEN 1205
            |:....:...||.|:|                 ::::|..:...|||::.|:.|.:.:..::...
  Fly   822 SQSDFGLDQGETLLRG-----------------MQDLREELNAFGETVATLQRRAQTVVPLNKRR 869

Human  1206 E-AQKQGDELAKLSSSFKALVTLLSEVEK-----MLSNFGDCVQYKEIVKNSLEELISGS----- 1259
            : ..:||.  .:...::|....|  ::||     :|.|.|. |:::.......|..|.|:     
  Fly   870 QPVNRQGP--VQAICAYKQQGQL--QIEKGETVTLLDNSGR-VKWRVRTAKGQEGPIPGACLLLP 929

Human  1260 ---KEVQEQAEKILDTENLFEAQQLLLHHQQKTKRIS----------AKKRDVQQQIAQAQQGEG 1311
               :|..:.||::   :.||:....|  .|:|..|:.          .|..|..|.:|...:...
  Fly   930 PPDQEAIDAAERL---KRLFDRSVAL--WQKKHLRLRQNMIFATIRVVKGWDFDQFLAMGPEQRT 989

Human  1312 GLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWERFETNKETVVRYLFQTGSSHERFLSF 1376
            .:....:::..||.|..|    ..:.|.||    ||: |..|.|:                  .|
  Fly   990 AIRRALNDDADKLLSEGD----PNDPQLRR----LRR-EMDEVNR------------------LF 1027

Human  1377 SSLESLSSELEQTKEFSK--RTESIAVQA--ENLVKEASEIPLGPQNKQL------------LQQ 1425
            ...|..:...|::|:.|:  ..|.:|:::  |::.:|..:|.|.|..:.|            .::
  Fly  1028 DEFEKRARAEEESKQASRIFTEECLAIKSKLEDMARELDQIILAPLPRDLDSLEHVLEIHSDYER 1092

Human  1426 QAKSIKEQVKKLEDTLEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQI 1490
            :...::.::|.|::|.........::|...|:.      :.:|     ||||   |.|.....::
  Fly  1093 RLHLLEPELKHLQETFRTIALKTPVLKKSLDNL------MELW-----KELN---TQSGLHKDRL 1143

Human  1491 SQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIKAK--------LTQIRRYGEELREHA 1547
            ..::.::..:|.....|..||.|........:|.|..:...|        :||.:...:::.:.|
  Fly  1144 KLLEASLAGLEDNEHVISELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAA 1208

Human  1548 QCL-----EGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQ 1607
            ..|     ...:||.|   ::...|:.::....|...::|...::.|.:|....|.||..:.:.:
  Fly  1209 DQLGRMGVPTKVLGDL---KRLHSNVERLNTRWSAVCNQLGERMRSCETAIGLMKNLQSSVQVEE 1270

Human  1608 A-----LESLSSAITAFSASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRL 1667
            :     .|.||:..||.||                   .:.:.:|..|.||:..:||:.....||
  Fly  1271 SWVDGTTERLSAMPTATSA-------------------YELDKLLGAAIERKPKIENVNVAGGRL 1316

Human  1668 EKELS-------SFLTWLERGEAKASSPEMDI-SADRVKVEGELQLIQALQNEVVSQASFYSKLL 1724
            .:|..       .|:.||.......|.|..|: .||  ...|..|              :||:.|
  Fly  1317 IREAKIYDSKCLRFVDWLVEARPSFSPPRRDLRPAD--SDPGATQ--------------YYSQRL 1365

Human  1725 QLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIK 1789
            .      ::.:|:|    :| ||||.:|                                     
  Fly  1366 D------NLNTKND----RL-LEQLSQR------------------------------------- 1382

Human  1790 LFLSELQTTSEISIMDH-QVALTRHKD-HAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGK 1852
                 |:|..|::..|. |.|.:..|. ....|:...|.:.:..|:.|      |.|||:     
  Fly  1383 -----LKTAIEVNGSDGLQYAESLQKPLKTFRVDFSAGSVPTGDGYAA------RQEDLY----- 1431

Human  1853 AEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGILRQLRQTVEATNSMNKNESDLIEKDLN 1917
                                                          ..|.|..:..|....|...
  Fly  1432 ----------------------------------------------TTTYSTTQISSTKTTKSST 1450

Human  1918 DALQNAKALESAA--VSLDGI-LSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSE 1979
            .::.::..|::|:  ||..|: .|:.|:      :|.||..|  :.||.|  ..:.::.|.:...
  Fly  1451 KSVYSSDGLDAASQEVSTAGLPQSQIQF------NEIRTLKR--SQQLGG--HSVLDIAGIRDPR 1505

Human  1980 ADALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQR-------LRVFNQLEDELNS 2037
            ...:..:.:|.|         :..::.||. |.|....|..|:|.       |::..||.:    
  Fly  1506 TGRVLTIGEAIQ---------LRILDVRTG-EMLVGDRRITLEQAADQGLIDLQLAKQLLE---- 1556

Human  2038 HEHELCWLKDKAKQIAQKDVAFAPEVDREINRLEVTWDDTKRLIHENQ----GQCCGLIDLMREY 2098
                    ....:..:.::::....:.|||:..|..::..::.|..|.    .|..|.:......
  Fly  1557 --------PGAGRDASGRELSLLEVIQREISEAESGYETAEKRIKVNNTVTVEQTSGELGSPENP 1613

Human  2099 QNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQK-----DLDNFTSKGKH 2158
            :|:..|::     |.|| .|:|.:                     |:.|     .|.....:|..
  Fly  1614 RNIADAIT-----AGSV-DTKTGL---------------------YRVKSGQTISLAEAYERGYL 1651

Human  2159 LLSELKKIHSSDFSLVKTDMESTVD--KWLDVSEKLEENM-DRLRVSLSIWDDVL--STRDEIEG 2218
            :..|...|.|:...|........||  .|:     .:.|. |:.|:..:|.:.::  |.|:.::.
  Fly  1652 IRHESVTIKSNALCLSDAIAHGLVDGAGWI-----ADRNSGDKFRLDSAIANQLIDASVREVVDA 1711

Human  2219 WSNNCV---PQMAENISNLDNHLRAEELLKE---FESEVKNKALRLEELHSK-VNDLKELTKNLE 2276
            ..:..:   ..:...:.|........|:.||   | :|.:|:.|.::....| :.||..|.|..:
  Fly  1712 KRDTKITLQEALQSGVLNAKTGRYVNEVTKEKLTF-AEARNRQLIVKPYTLKDICDLNLLDKQAQ 1775

Human  2277 TPPDLQFIEADLMQKLEHA-------KEITEVAKG---TLKDFTAQSTQVE---KFINDITTWFT 2328
            ....::..:..:||.:|..       |.||: .||   ||::..|....:.   |:.:.:|....
  Fly  1776 ITSPMRREKLSIMQAIEAGVLDGNLLKCITK-RKGELVTLQEAIADGIVLPAECKYRDFMTGELI 1839

Human  2329 KVEES-----LMNCAQNETCEALKKVKDIQ--KELQSQ---QSNISSTQENLNSLCRKYHSAELE 2383
            .:.|:     :.:.||       :.:.||.  |:|:|.   ..|::.:::.|.   ||.....||
  Fly  1840 SIPEAVERGLISSVAQ-------RSIFDIDGFKDLRSNDYVSFNVALSRDLLR---RKSTGFALE 1894

Human  2384 SLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWF---LGAK-AAAKESSDRTG 2444
            : ||  ..|:....|||           |.|.:      ||..|.|   :|.: |:.||.|    
  Fly  1895 T-GR--DSLVPLEVAVS-----------EGLVR------QEVYEMFSRGIGVQNASGKELS---- 1935

Human  2445 DSKVLEAKLHDLQN-----ILDSVSDGQSKLDA------VTQEGQTLYAHL------SKQIVSSI 2492
               |.:...|:|.:     :||..:.....||.      :|.||..|.:.|      ::.:..:|
  Fly  1936 ---VFDLVYHNLIDPKTGYLLDPKTGETVPLDTAIERKFITPEGALLLSSLLNITLTTETVTRTI 1997

Human  2493 QEQIT---KANEEFQAFLKQCLKDKQALQDCASELGSFEDQHRKL-------NLWIHEMEERFNT 2547
            ...:|   .:.|...:.|   |...:|::.      .|.|:.|:|       |  |:.:::..|.
  Fly  1998 NRYVTIRAGSQEPVDSVL---LTFTEAVRQ------GFIDEERQLFKDPKTGN--IYSVQQALNY 2051

Human  2548 ENL-GESKQHIPE---KKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQL 2608
            ..| .:|.|.:||   :|.....:.:...:::...|.:...:|..:.:.:     ..|..:..:|
  Fly  2052 GLLVPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVEK-----SVEIPISQEL 2111

Human  2609 LTSHQNLLRMTKEKLRSCQVALQEHEALEEALQSM----WFWVKAIQDRLACAESTLGSKDTLEK 2669
            :..|    |:..|.:...:.:..|....|..:..:    |        ||         ||.:|:
  Fly  2112 VKPH----RVVSEFINLEKSSYIEQNVTERQIMELPPGGW--------RL---------KDAIEQ 2155

Human  2670 RLSQIQDILLMKGEGEVKL-NMAIGKGEQALRSSNKEGQRVIQTQLETLKEVWADIMSSSVHAQS 2733
            ||.. .|..:...:|..:| |.     |:.:   ||  |.:....|..:.....|    .:..||
  Fly  2156 RLFN-PDTGVFHVQGTDRLVNF-----EECI---NK--QIINNLSLSVIDPNTGD----KISVQS 2205

Human  2734 TLE-SVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEAEDHTRAL 2797
            ..| .::..:.:|...:.|::....::|:                      ..|:.|....||. 
  Fly  2206 AFERDILDSYGNYTNSRKQVQGMRSAIDE----------------------SKIILETVPATRG- 2247

Human  2798 HRLIAKSRELYEKTEDESFKD-----TAQEELKTQFNDIMT-----VAKEKMRKVEEIVKD---H 2849
                |..:.:...|:..:..|     |..::...:|.:::|     .:.|.::.....:.|   .
  Fly  2248 ----ANQKTILRITKVNNIPDVLEVSTPLKDAPPKFVEVLTCQRELASPEPLQIAPGAIYDPSTA 2308

Human  2850 LMYLDAVHEFTDWLHSAKEELHRWSDMSGDSSATQKKLSKIKELIDSREIGASRLSRVESLAPEV 2914
            |:......|..:...:|::.|            ..::|.||.:....:.|     |..|::|..:
  Fly  2309 LVIFTQTGETENIFDAARQGL------------VDEQLIKIVDPTTKQPI-----SVTEAIARSI 2356

Human  2915 KQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLV------SQMALSEQEF-----SGQ 2968
            ....||:   ::.:|.|.:        |.:..|:..|.::|      ::.||....|     :|:
  Fly  2357 YDPKTAT---ILDSEGQPV--------DLITATKLGLLSVVGAPLVAAEGALRTVRFVTDPRTGE 2410

Human  2969 VAQLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTED-LKSQL-- 3030
            ...:|.|.|      :....:..|..|::.|.|......| ..:|..::|...:.:| |:..:  
  Fly  2411 QIPVEVAYE------RGIVSRDQLHRGRSFDSEPATVEDK-VVVLQRMRKVILKPKDALRKGIID 2468

Human  3031 NELCRFSRDLSTYS---GKVSGLIKEYNCLCLQASKG----CQNKEQI-LQQRFRKAFRDFQQWL 3087
            .|.|....:.|.::   |:|..:.:..|...:...:|    .||...: |:|...:...|.:| .
  Fly  2469 EETCEILENTSNFTNPKGEVVNITEALNTGLIDGRRGQVIDPQNNRVLNLRQAVEQKIIDSEQ-T 2532

Human  3088 VNAKITTAKCFDIP----QNISEVSTSLQKIQEFLSESENGQ-------------------HK-- 3127
            .:..:..||...:|    |.:.:..|      :.:...|:|.                   ||  
  Fly  2533 NHILMPLAKSLSVPRLADQGLIDPQT------QTIVHPESGYPLSIHEAIVCEVLDPHSKLHKPE 2591

Human  3128 ---LNMMLSKGELL---STLLTKEKAKGIQAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFE 3186
               |...::||.:.   ||...|.|...|...:.|     |.|..:..|::|.:|...:.| .|.
  Fly  2592 KCTLEEAITKGIINADDSTFNYKNKTLNITEAIEA-----KLFDPSYDQQKSKVEIPPVGM-IFP 2650

Human  3187 VSAEPIQDWLSKTEKMV-HESSNRLYDLPAKRR-EQQKLQSV--------LEEIHCYEPQLNRLK 3241
            |:.|  :..:..::::| |.|:.:.  ||.|:. |:..:.|:        :|.:...|..|  :.
  Fly  2651 VAVE--KSLVEPSKRVVLHPSTKKA--LPIKQAIEENFIMSIPYSPKPDAIEVVTAMEQDL--ID 2709

Human  3242 EKAQQLWEGQAASKSFRHRVSQ-LSSQYLALSNLTKEKVSRLDRIVAE----HNQFSLGIKELQD 3301
            ..||.|   ...|...|..:.| :.:..|.:.||:       |.::.:    ..:....::.:..
  Fly  2710 VAAQTL---TVPSTGERIPLRQAMENGVLVVKNLS-------DFVITQKPIPKTEIMETVRAVHT 2764

Human  3302 WMTDAIHMLDSYCHPTSDKSVLDSRTLKLEALLSVKQEKEIQMKMIVTRGESVLQNT------SP 3360
            ..|..|.::..|...:::    :.:.:....:.|:::.||:.    :.|.||..:.|      ||
  Fly  2765 VTTKTIELMQGYVLISNN----EVQNVNTGEVCSLEEAKELG----ILREESTTRETKAAAGESP 2821

Human  3361 EGI----------PTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSM 3415
            |.:          ..::::.|:|      ::|:..| |.::: .:|...|.:          |:.
  Fly  2822 ESVGDVGTSGDQTVIVEERTQTV------VVSSDTR-KQEMQ-VVSTTQSTK----------DTS 2868

Human  3416 EANLNESERQHAELRDKT-------TMLGKAKLLNEEVLS-------YSSLLETIE--VKGAGMT 3464
            ..:::|.|.:.::...||       ..||...::...||:       ..||:::::  .:.|..|
  Fly  2869 VPSVSEIETKGSKEPSKTLQNVKDAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSPTEDAKST 2933

Human  3465 E-------HYVTQLELQDLQERYRAIQERAKEAVTKSEKLVR------LHQEYQRDLKAFEVWLG 3516
            |       .::.|...::||.  :.:.......::::|..:.      :..|.|:|         
  Fly  2934 EKPKEPQTSFIEQERRKELQP--QQVPSEVDNLLSETENFISSTTANFIANEKQQD--------- 2987

Human  3517 QEQEKLDQYSVL----EGDAHTHETTLRDLQELQVHCAEGQ---ALLNSVLHT-RED---VIPSG 3570
             :.:.|.|.|.|    |..:....||:..:.........|.   .::..|..| :||   |.||.
  Fly  2988 -KPDTLPQESNLPLEVESTSTLTTTTVTTITTSSTTTETGNLEPVVVEDVSTTVKEDKVVVKPST 3051

Human  3571 IPQAEDRALESLRQDWQAYQHRLSETRTQFNNVVNKLRLMEQKFQQVDEWLKTAEEKVSPR---- 3631
            :|  ||:...|          :::||.|...:  |:...:.:|..|     |:|.|:.:.:    
  Fly  3052 VP--EDKTEVS----------KITETITTVTS--NETDTVPEKISQ-----KSASEESAKKDPVV 3097

Human  3632 TRRQSNR------ATKEIQLH------QMKKWHEEVTAYRD-----EVEEVGARAQEIL--DESH 3677
            |:..|:|      :.|.:|..      |..::.|.:.  :|     :.:|....|.:|.  :.|.
  Fly  3098 TKDTSSRPAETETSPKPVQKEPTPDPAQNTEFPESIK--KDPTPEPDYKETATEAAQITPKEASP 3160

Human  3678 VNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQSLEES-ESSLSSYSDWYGSTHKNFKNVATK 3741
            ..:....|:.:.||:.:.:....      .:|||..:|.. .:.|:.:.|         :...||
  Fly  3161 APTNKNEQSAEPTSKPEPMPRTA------KKEEISEIEPPFTAPLAPFVD---------QLAETK 3210

Human  3742 IDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHMEQLKE 3806
            |.::.|..                                             ||.....:.:..
  Fly  3211 ITEIKTEF---------------------------------------------KEPVTSSQTITT 3230

Human  3807 LTSTVR--KEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPE--------EPKMEL-YEKK 3860
            :|:||:  .||..:|:...::|  |:|...:.:.....||.:.|.|        ||..|: :|::
  Fly  3231 ITTTVKTVDEHPIVEEVDEVSK--SEKIVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEER 3293

Human  3861 AQLSKYKSLQQTVLSHEPSVKSVREKGEALLELVQDVTLKD---------------KIDQLQSDY 3910
            ....:..::.:|.::......:.....|..|......|:|:               :|:|..:|.
  Fly  3294 VVTVEEPTITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEIEQTTNDD 3358

Human  3911 QDLCSIGKEHVFSLEAKVKDHEDYNSELQEVEKWLLQMSGRLVAPDLLETSSLETITQQLAHHKA 3975
            |           ....::.|.|...:|.:.||         .:..:.:.||...|:|        
  Fly  3359 Q-----------KKPEEIVDTEKKTTEQKPVE---------TIPTEPISTSETTTVT-------- 3395

Human  3976 MMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSLEH 4040
                          |..| .|::.:...|..:.::|.:..|  .|.|                  
  Fly  3396 --------------LTTK-TTIVDEGKLHPPSDIEQIIQPH--STSD------------------ 3425

Human  4041 ELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCD 4105
               ||.|..|.::|            |...||....:..::.||....|...|.....:|.    
  Fly  3426 ---KHQSLVDFIEQ------------EKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLA---- 3471

Human  4106 LSNASVKTTAKDIQQTEQTIEQKLVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSEL 4170
             ..|.|     |...||:|::.:...:|.:|   |.::.|.:|:                     
  Fly  3472 -GKALV-----DALTTEKTLKPEHSTSQVVT---ETVEELPTEI--------------------- 3506

Human  4171 ELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEINHLNDQWLDLCRQSNNL 4235
                   :.:.....|.|:.:...:..|        :..|.:|:        |:.||:.:....|
  Fly  3507 -------ITTSTATLVTKVTTTTTTTTT--------STSEGTPD--------DEALDVVKLPAEL 3548

Human  4236 ---CLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKL--------- 4288
               .::||  :.||....|.::...:..::.....|...:|...||.:..|.|..|         
  Fly  3549 VESSVKRE--VPRTLAIGDAISQKLISPDECQVIVDGEQQSQTVSTLLKEEQLSPLDEVQIIDDK 3611

Human  4289 ALALQERKYAIE-DLKDQKQKMIEHLNLDDKE-----------LVKEQTSHLEQRWFQLEDLIKR 4341
            .:.||:..|.:: |.:...|.:.| ||:.|.|           .:...|...:...|..|.::.:
  Fly  3612 LIVLQQVSYLVDADTELTPQNLYE-LNIYDPENQYFIDPSTGQKISFHTLVFDMNVFNPETILVK 3675

Human  4342 KIQVSVTNLEELNVVQSR--------------------FQELM--EW-----AEEQQPNIAEALK 4379
            ..  |....|.|.....|                    |.|.:  :|     .|||:|:   .::
  Fly  3676 NF--STGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRANPEEQKPS---GIE 3735

Human  4380 QSPPPDMAQNLLMDHLAICSELEA---KQMLLKSL-IKDAD-------RVMADLGLNERQ----- 4428
            ..........:::|...:||.:||   .::.::|: ::|..       |:..:||:.:.|     
  Fly  3736 NVTIDTQTGQVVLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIELGVVDMQAGTVI 3800

Human  4429 -------------------------------VIQKALSDAQS----------------------- 4439
                                           .::|.|.|.::                       
  Fly  3801 DIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETGKLFDSESQNQVDVQKSIEIGLV 3865

Human  4440 --HVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREHICLLPDDVSKQVKT 4502
              .::.:.|.|.::...|:.|:.:.     .|..||.||:.::..       .|:|.||..|   
  Fly  3866 DPKISLIVDTVTKKEVKLDCAIEDD-----LVLPATGQIKDNKNN-------TLVPFDVGVQ--- 3915

Human  4503 CKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKN 4567
                |..|||  :.||  |:....|.:|.......:||..:...:.:....::.   ...|||..
  Fly  3916 ----QCLLKT--DNVT--WSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEM---GFVELETT 3969

Human  4568 LVSRKHFKEDFDKACHWLKQADI---------VTFPEINLMN----------------------- 4600
            ||.    ..|.||.....:.|.:         ::.|.|:|..                       
  Fly  3970 LVK----DVDHDKILPGKEAAKVGLLDTVRGTLSSPNISLDEAFVKGYLISTKKPLSLVDCLLRG 4030

Human  4601 -----------ESSELHTQLAKYQNILEQ------SPEYENLLLTLQRTGQTIL-PSLNEVDHSY 4647
                       :..:|..:.|..|.::..      .|:.|:::...:...:..| |....|.:.|
  Fly  4031 LYDPSTAKFTIDDKQLDLKAAIAQKLINPEELVLLDPKTESIISITEAIAKGYLDPIEGYVINPY 4095

Human  4648 LSEKLNALPRQFNVIVALAKDKFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLA 4712
            .|.||:......|.|:...|.| ..:.:|:     |..|.:..|...|..    :...|:.|:.|
  Fly  4096 ASTKLSLHEALENRILIPPKRK-RSLPDAV-----YRGLYDPKTGQFSNT----VTREKLTTERA 4150

Human  4713 VEEALSLQDGC-----------------RAILDEVAG-LGEAVDELNQKKEGFRSTGQPWQPDKM 4759
            :...:...|..                 ..|:|...| :.:|.|.....||.| ..|...:..|.
  Fly  4151 IRRGILDPDSTVVNVGSGQIIPFGVATETGIVDSKHGTVRDADDHPIDFKEAF-DRGILVEAKKP 4214

Human  4760 LHLV-----TLY-----HRLKRQTEQRVSLLED-TTSAYQEHEKMCQQ----LERQLKSVKEEQS 4809
            |.|:     .:|     |.:..::.::::..|. .|:...||....:.    |.:||.....:.:
  Fly  4215 LRLIEAVVKNVYDEVDGHFVDPKSGEKLNFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKDT 4279

Human  4810 KVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLEDLAPHLD---PLAYEKARHQIQSWQGE 4871
            .:    :.|:....:|::...:|:           |..|:...:|   |::.::|.||.......
  Fly  4280 GI----IDAQNSKLLYNNQTMTLK-----------HAFDIGILMDVNAPISIQRAIHQGLFDDKT 4329

Human  4872 LKLLTSAIGETVTECES--------RMVQSIDFQTEMSRSLDWLRR---------VKAELSGPVY 4919
            .||.....|..:|..||        .:....|.|||...:|....|         |..|.....:
  Fly  4330 GKLSDPRTGRQITLLESMRSFVVNPHLPCYFDEQTEQMYTLSETCRNGIINRREGVFREPGSNSF 4394

Human  4920 LDLN-------LQDIQE------EI-------------------RKIQIHQEEVQSSLRIMNAL- 4951
            :.|.       :.||:.      |:                   ||:.:::..|:..:.:.::| 
  Fly  4395 VPLGEALSLGLIVDIENAGFGLYELLSMGFYETSTRKVLHPVTNRKLNLNEACVEDVVSLSSSLV 4459

Human  4952 SHKEKEKFTKAKELISADL---EHSLAELSELDGDIQEA------LRTRQATLTEIYSQCQ---- 5003
            .|.|..|:.:....|...|   ......|.....|:|.|      :..|:....|:..:.|    
  Fly  4460 KHHETGKYLRLANAIKEQLVDDSRGCYNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRP 4524

Human  5004 -----------RYYQVFQAANDWLEDAQELL---QLAGNGLDVESAEENLK---SHMEFFSTEDQ 5051
                       .|..:.:|.:....|....:   ||.|..|.:..|.||..   |....|..:.:
  Fly  4525 ETGKFCDPTTGEYLDLIEAIHSGFIDPATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSK 4589

Human  5052 FHSNLEELHS---LVATLDPLIKPTGKEDLEQKVASLELRSQ-----------RMSRDSGAQVDL 5102
            ...|.:...|   ||....||   |.:.|:.::..|:||.:|           .||.:...:.::
  Fly  4590 SAYNYDVALSRGILVTITRPL---TDRNDVVRRQDSVELLNQTPVSVVISKPREMSLEEAIRYNI 4651

Human  5103 LQRCTAQWHDYQKAR----EEVIE--LMNDTEKKLSE-----FSLLKTSSSHEAE----EKLSEH 5152
            :...||...|:...:    ...:|  |::.|::.|.:     |:...|...:..|    ::.:|.
  Fly  4652 IDPKTALVRDFDSFKFLPYSVAVERGLVDTTKRTLVDPKALYFAFDPTLIVYVREPVTFDQAAES 4716

Human  5153 KAL-------------------------------VSVVNSFHEKIVALEEKA--------SQLEK 5178
            |.|                               ::|:.:  .|:..|:|.|        |.|.|
  Fly  4717 KCLDLQTGLLTYVPASVPGSATAAPASDDSANDSLTVIET--PKVYTLKEAASAGVVDPDSALVK 4779

Human  5179 TGNDASKATLSRSMTTVWQRWTRLRAVAQDQEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPG 5243
               |.:||.|.|              :.:...|.|.|| ::....|.:..|...:.:..:..|..
  Fly  4780 ---DLAKAKLVR--------------LPEAFRKGLMDA-NKANVLNTQTSKLCTLQEAYESGLIC 4826

Human  5244 SSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSM-------LQDGAA-----PTPGE 5296
            :........|.:|...|:.|....::..|....::|::..::       |.|.::     |:.|.
  Fly  4827 TPKRSFGLLEAITFNLYNPTNGCLVDPFQMHPDIIRRRKFTLAEAIGSGLVDPSSTVVRDPSTGV 4891

Human  5297 EPPLMQEIT-----AMQDRCLNMQEKVKTNGKLVKQELK-------DRE-------MVETQINSV 5342
            ..||...|:     |.:.|..:..|. |.|..|||...|       .|:       |.|..:|.:
  Fly  4892 IVPLTAAISSGLIDATEGRLTDANEP-KNNIDLVKAAEKGLLLPAEQRQAVFEKFNMCEENVNDL 4955

Human  5343 KCWVQETKEYL---GNPTIEIDA---QLEELQILLTEATNHRQNIEKMAEEQKEKYLGLYTILPS 5401
            ..||...::.:   |.|..:||.   |:..|:.:..|..:.::.:....|:.::..|....:|.:
  Fly  4956 LKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIESQQRPVATCLEQIRQIVLTGGDVLSA 5020

Human  5402 ELSLQLAEVALDLKIR-DQIQDK-IKEVEQSKATSQELSRQIQKLAKDLTTI------------- 5451
            .....|.....:|:.| |::.|: ::.:.:.:|...||:    ||..:|...             
  Fly  5021 PEVTTLENSGRELRSRVDRVNDRTVRLLRRLEAGRDELT----KLRSELDVFSDWLQVARRTLED 5081

Human  5452 -------LTKLKAKTDNVVQAKTDQKVLGEELDGCNSKLMELDAAVQKFLEQNGQLGKPLAKKIG 5509
                   ||:|.::.|:|.:..:|  |:|.:.|     |..:..|.|||::::.:....|.....
  Fly  5082 KERSLSDLTRLPSQADSVREFVSD--VIGHQAD-----LRFITMAAQKFVDESKEFLAILNDFRT 5139

Human  5510 KLTEL--HQQTIRQAE------------------NRLSKLNQAASHL----EEYNEMLELILKWI 5550
            .|.|.  |.:.:..||                  ||::.|....|.|    .||.:.|:...:|:
  Fly  5140 SLPERLPHVEPLSSAESPIRQEVSLVSAQYKDLLNRVNALQDRVSGLGGRQREYQDALDKANEWL 5204

Human  5551 EK-----AKVLAHGTIAWNS---ASQLREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTE 5607
            ..     :::::. .||.:.   ..|:.|...||..||...:.:|:..:|:...|:.|.......
  Fly  5205 RSVHPRVSRIISE-PIAGDPKGVQDQMNEAKALHNELLSSGRLVDNAQQALDNLLRSLGGQLSPM 5268

Human  5608 KMSQ---QVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALE-------QAQ--- 5659
            :::|   .:|:|....::|       |.||.:..|.:.|...:.:.:|.||:       ||:   
  Fly  5269 EINQLELPIADLKNNYQQL-------LDNLGEHCKTLDKTLVQSQGVQDALDSLVGWVNQAEDKF 5326

Human  5660 -ATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSAL-------RIPEDVVASL-PL 5715
             ..|....:.:..|:||:...:.||::::|.:..:.:||:....|       ||.:.|.::| .:
  Fly  5327 KMNLRPASLIKERLQEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKKVESNLNDV 5391

Human  5716 CHAALRLQEEASRLQHTAIQQCNIMQEAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE 5780
            .....:|.|:|::.........|.:...:.:....||.|..||:.::..    |...::|..:..
  Fly  5392 TVKFEKLYEKANKRGEFLDDVYNRLSRYLDEISTVEQRMASLQEALDSR----ETSLLSTEELAR 5452

Human  5781 LQAQISRHEE---------------------------LAQKIKGYQEQIASLN----SKCKMLTM 5814
            ...::||.::                           |..:||..:.|..::|    .:.|:...
  Fly  5453 RMNELSRDKDQLAPQFEDCVRSGKDLISLRDVTDTGVLRDRIKALESQWRNINISIDERAKLSKQ 5517

Human  5815 KAKH------------ATMLLTVTEVEGLAEGTEDLDGELLPTPSAHPSVVMMTAGRCHTLLSPV 5867
            ||:.            :.:..|...|.||.....|||                ...:.|..|.|:
  Fly  5518 KAEQQLAYEGLKDQVLSWLASTEARVNGLPPVAIDLD----------------RIKQQHDELKPI 5566

Human  5868 TEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSA-SQEF 5931
                              |:.....|.|...:|...|.|.||           |.|.:.| .:..
  Fly  5567 ------------------CKDYRDYAPTIDKINDIGAQYDAL-----------IRPESPARKRST 5602

Human  5932 YEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSES 5996
            |.|....|...::....||....|..|.....|.......::..||..|  .:::..::.:|||.
  Fly  5603 YSPIKRTSPLRRMSGDARSPSPTKGGILSPLSTGSSGFGSRRSSQDGFQ--LSELSPVQQQLSEI 5665

Human  5997 PEPGRSPESQMAEHQSFLQALMDEILM-------LQDEINELQSSLAEELVSESCEADPA----- 6049
            .........::.:.|..|..|.:|:..       |...:..:|..|.:|.||...||:..     
  Fly  5666 NNRYGLIGVRLNDRQHELDNLNEELRKQYENLKGLAQFLERIQRQLPKESVSNKDEAERCIKQAR 5730

Human  6050 ----EQLALQSTL-TVLAERMSTIRMKAS--GKRQLLEEKLNDQLEEQRQ------------EQA 6095
                :....||.| |..|:....:|.|:.  |..||.:|  ||.::|:.:            .:.
  Fly  5731 KILEDMYEKQSLLDTTKAQVKDILRRKSDVPGAEQLRQE--NDSIQEKWKNLNDICKNRIAFSEK 5793

Human  6096 LQRYRCEADELDSWLLSTKATLDTALSP-PKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNE 6159
            |:.:......|.|| |.:|..:.|.|.| ..:|..:::|:...|.:..|...:...|.    |.:
  Fly  5794 LRDFLDTHGNLKSW-LDSKERMLTVLGPISSDPRMVQSQVQQVQVLREEFRTQQPQLK----HFQ 5853

Human  6160 NL---LLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQQGTAQEKEESDVDLTATQS 6221
            .|   :::..|.|.| |:.:..||:.:.|...:|...|.|: .|...|.|...:|.|..:...:.
  Fly  5854 ELGHDVVDHLAGTPD-AQAVEIKLKDILGKWDDLVGKLDDR-ANSLGGAADSSKEFDAAVNRLRE 5916

Human  6222 PGVQEWLAQARTTWTQ-QRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAA---ETSGD 6282
             .:|.......|..|. ..|.:|::.:.||::|..|:.||..|         :.|||   ...||
  Fly  5917 -ALQNISDNLDTLPTDGDHQENLRKIENLERQLEGQRPLLADV---------EQSAATLCNILGD 5971

Human  6283 AGEKPDVLSQELGME---------------------------------------GEKSSAEDQMR 6308
            ...:.||.|:...:|                                       ||.|:..|::.
  Fly  5972 PASRADVNSRVAALEKQYLALQKKLDTKKAETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLL 6036

Human  6309 MKWE--SLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLN 6371
            :...  :|..:..|.:.:.:.|:.:|.|.::.....:.|:         ..|....|...||.:.
  Fly  6037 VSAHKPTLQHQIDTHEPIYREVMAREHEVIMLINKGKDLT---------DRQQDRGVKRDLDRIQ 6092

Human  6372 QAFEEVSSQSGGAKRQSIHLEQKL---------YDGVSAT-STWLDDVEERLFVAT--ALLPEET 6424
            |.:|::       :|:::....:|         |...|.| ..||...|::|...|  .|...:.
  Fly  6093 QQWEKL-------RREAVDRHTRLQTCMEHCKKYSQTSETFLAWLRTAEDKLADLTPGVLSKAKL 6150

Human  6425 ETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGD-NRDVIEDTLGCLLGRLSLLDSVVNQRC 6488
            ||.|.:.:....::.:.|.|.:..|.| .:.|..:.| :::.|:..|..:..|...|::.:..|.
  Fly  6151 ETRLRDLQTFRSEVWKHSGEFENTKGL-GETFLSSCDIDKEPIKAELQDIRDRWERLNNDLIARA 6214

Human  6489 HQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDA--G 6551
            |:::...:::.:|.::|:.|..||.                          :.||.|...||  |
  Fly  6215 HEIENCSRRLDDFNDELRNLDHSLG--------------------------RCEDRLAAHDALGG 6253

Human  6552 IIELKRRGDKLQVEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLET 6616
                       ..:.|.:.|                 |...:.:.||..|:..::|:.||..:..
  Fly  6254 -----------AAKDPKLLE-----------------RVKAIREELTNLSKPLQSLKALAKDISA 6290

Human  6617 GQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHMILTETLFRKIISFAVQKETQFHTELMAQ 6681
            ......||...:.|   |:..|.|:..|....|:...                      .||.:.
  Fly  6291 EARAAGGDADHLTS---EVDGLADRMSELQGRLDDRC----------------------GELQSA 6330

Human  6682 ASAVL---KRAHKRGVELEYILETWSHLDEDQQELS---RQLEVVESSIPSVGLVEENEDRLIDR 6740
            |:||.   ::....|::|       :.|:.:.::||   |::::|:..|..||.::...|||:.|
  Fly  6331 ATAVSQFNEQMKSLGIDL-------NDLETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGR 6388

Human  6741 ITLYQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETI 6805
                                 |:|.:|....:..:...:...|..|    ..:.:.|.|.||:..
  Fly  6389 ---------------------LEDAERAADVLVDAGFAADTTQTRE----QISTLRKTLGRLDNR 6428

Human  6806 LKHWTRYQSESADLIHWLQSAKDRLEFWTQQSVT----------------VPQELEMVRDHLNAF 6854
            ::       :..|.:|  .:.|...||:..||.|                |..||:.:|.....|
  Fly  6429 VR-------DHEDNLH--STLKALREFYDHQSQTLDDIQDVSDEFKRMKPVGSELDQIRRQQEDF 6484

Human  6855 LEF-SKEVDAQSSLKSSVLSTGNQLLRL--KKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQ 6916
            ..| .::|:..:.....|...|..|:|.  ..|.|..:..:|.:::.:|.||...   :.|:..:
  Fly  6485 RNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVSTTAIEKDLEKLNDRWNDLKER---MNERDRR 6546

Human  6917 LQMDKLPS---RHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLT 6978
            |.:..|.|   :.|::.:..|:|..|.::...:   ..|..||.:...||:.|..      |::.
  Fly  6547 LDVALLQSGKFQEALAGLSKWLSDTEEMVANQK---PPSSDYKVVKAQLQEQKFL------KKML 6602

Human  6979 VDFVNQ--SVLQISSQDV-ESKRSDKTDFAEQLGAMNKSWQILQGLVTEKIQLLEGLLESWSEYE 7040
            :|..|.  |:..:..:.. ..:..::....:||..:.|.:..|.....::...||..:|....:.
  Fly  6603 LDRQNSMGSLANLGKEVANHCEPGERASIEKQLNDLMKRFDALTDGAEQRELDLEEAMEVAKRFH 6667

Human  7041 NNVQCLKTWFETQEKRLKQQHRI-GDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQNK 7104
            :.:..|:.|.:..|:.:|....| .|:..:|..:::...|.|                  .|..|
  Fly  6668 DKISPLELWLDNTERSVKAMELIPTDEEKIQQRIREHDRLHD------------------EILGK 6714

Human  7105 KEDVSSIVMSTLRELGQTWANLDHMVGQLKIL-----LKSVLDQWSSHKVAFDKINSYLMEARYS 7164
            |.|.|        :|....|.|.|:|...:.:     ::.|.::::....|.|.|.:.|.|:|..
  Fly  6715 KPDFS--------DLADVTAQLMHLVSDEEAVNLGEKVRGVTERYTGLVDASDNIGALLAESRQG 6771

Human  7165 LSRFRLLTGSLEAVQVQVDNLQNLQDDLEKQERSLQKFGSI---TNQLLKEC------------H 7214
            |....|             :.|:|...:|..|..|::|.|:   ..:||::.            |
  Fly  6772 LRHLVL-------------SYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIAGH 6823

Human  7215 PPVTETLTNTLKEVNMRWNNLLEEIA--EQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNEL 7277
            ....|:...:..|       |::.|:  |.:|....|..|.:||.|.:           :|..:|
  Fly  6824 ASNVESTVESGAE-------LMKHISNDEAIQLKDKLDSLQRRYGDLT-----------NRGGDL 6870

Human  7278 LKAATNK-------DIADDEVATWIQDCN-----------DLLKGLGTVKDS---LFFLHELGEQ 7321
            ||:|.|.       ..|.:.:..|:|...           |:|:..|.:.|.   |..::::|.|
  Fly  6871 LKSAQNALPLVQQFHEAHNRLVEWMQSAEAALAPSEPRQADVLRLEGELADMRPILDSINQVGPQ 6935

Human  7322 LKQQVDASAASAIQS-------------DQLSLSQHLCALEQALCKQQTSLQAGVLD--YETFAK 7371
            |.|......|:.|:|             :|:........|.....|:.|    |.:|  .|.|.:
  Fly  6936 LCQLSPGEGAATIESIVTRDNRRFDSIVEQIQRKAERLHLSNQRAKEVT----GDIDELLEWFRE 6996

Human  7372 --------SLEALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNEL 7428
                    .|.|:|..:|.|:  || :..|.:.|:|:.:.|:.::.....|....:|..:  |..
  Fly  6997 MDTTLREADLPAMEPKLVRAQ--LQ-EHRSINDDISSQKGRVRDVTAASKKVLRESPQSE--NTA 7056

Human  7429 GYRLPLND-KEIKRMQNLNRHWSLISSQTTERFSKLQSFLLQHQTFLEKCE---TWMEFLVQTEQ 7489
            ..|..|:| |||.         ..::...:||...|:..|...:.|.:..:   .|::.:.|...
  Fly  7057 TLREKLDDLKEIV---------DTVAQLCSERLGILEQALPLSEHFADSHQGLTAWLDDMEQQIS 7112

Human  7490 KLAVEISGNYQHLLEQQRAHELFQ--AEMFSRQQILHSIIIDGQRLLEQGQV-------DDRDEF 7545
            :|::......|..|:|.:...|.|  ||        |..::|  :|.:.|:.       ||..:.
  Fly  7113 RLSMPALRPDQITLQQDKNERLLQSIAE--------HKPLLD--KLNKTGEALGALVADDDGAKI 7167

Human  7546 NLKLTLLSNQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLV----EVSYL-PMSGL-GS 7604
            |..|...:.::..:....::|:..::|.:::..::.:..|.:.:.|.    :|:.| |:|.| ..
  Fly  7168 NEILDTDNARYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVDQVNQLDPLSALPQK 7232

Human  7605 VPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQLLLSADSGAEAA---LQAELAEIQEKW 7666
            :...::....|.|::.       ::|.::.....|...::..|.:.|:.|   ::|:|.::...|
  Fly  7233 IREQIEDNDALMDDLD-------KRQDAFSAVQRAANDVIAKAGNKADPAVRDIKAKLEKLNNLW 7290

Human  7667 KSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPD--HHEELHAEQMRCKEL 7729
            .......:::...|..:|...|...|.:...::.|:..::.||...|.  ..:::..:|:..:|:
  Fly  7291 NDVQNATKKRGSSLDDILSVAEPFWKQLNSVMKTLKDLEETLSCQEPPAAQPQDIKKQQVALQEI 7355

Human  7730 ENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEW 7794
            .:.:.....::.|:......|.......|...:.:.:|.|...|:.:....:.|.:.:.:.:.:.
  Fly  7356 RHEIDQTKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDLDNAWDNITALYAKREENLIDAMEKA 7420

Human  7795 AVFSEKNKELCEWLTQMESKVSQNGDI-----LIEEMIEKLKKDYQEEIAIAQENKIQLQQMGER 7854
            ..|.|..:.|.::||:.|.|.:..|.:     .::..||:| |.:::|:.........|.:....
  Fly  7421 MEFHETLQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQL-KSFKDEVDPHMVEVEALNRQAVE 7484

Human  7855 LAKASHESKASEIEYKLGKVNDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRTWLAHIESE 7919
            |.:.:...:|:.|...|..||.||:.||..:..|.|:|:..|:.:.|....::.|..|:...:|.
  Fly  7485 LTERTSPEQAASIREPLSVVNRRWEALLRGMVERQKQLEHALLHLGQFQHALNELLVWINKTDST 7549

Human  7920 L--AKPIVYDSCNSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATDAECDSIQ 7982
            |  .|||..|   .:.::.:|.:.:.|..||:.|...|.:        |:|......:.|..|::
  Fly  7550 LDQLKPIPGD---PQLLEVELAKLKVLANDIQAHQNSVDT--------LNDAGRQLIETEKGSVE 7603

Human  7983 QAT-----RNLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKSSERTAAFPSSSGV 8042
            .:|     |.|:..|:.:...:.:|:.::||..|....::.:......||...:.........|.
  Fly  7604 ASTTQEKLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLGDVDAVIGASKPVGG 7668

Human  8043 IYTVAKEELKKFEAFQRQVHECLTQLELINKQYRR-LARENRTD-SACSLKQMVHEGNQRWDNLQ 8105
            :...|.|:|::|.....::.|...::|.|..|.:. :.|:|:.. |:.:|:..:....||||.:.
  Fly  7669 LPETATEQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVV 7733

Human  8106 KRVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSEC--DVQAKIKQLKAFQQEI 8168
            .|.:....:|:..:.:..||.....:.:.|||:.:..|:|.|..|..  .:||::::.|..|:::
  Fly  7734 SRASDKKIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDV 7798

Human  8169 SLNHNKIEQIIAQGEQLIEKSEPLDAAIIEEELDELRRYCQEVFGRVERYHKKLIRLPLPDDEHD 8233
            |.:...:..:..:|..|...|:..|..:|:..|..::...:.|..:.....:.|        :|.
  Fly  7799 STHREAMLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERVVSKAAERTRAL--------DHG 7855

Human  8234 LSD-RELELEDSAALSDLHWHDRSADSLL-------SPQPSSNLSLSLAQPLR-----------S 8279
            ..: ||.....|..:..|...::..|.::       .||........|.:..|           :
  Fly  7856 YKEAREFNDAWSGMMQYLQETEQVLDQIIEEATASKEPQKIKKYIGKLKETHRQLGAKQSVYDGT 7920

Human  8280 ERSGR---------DTPASVDSIPLE--------WDHDYDLSRDLESAMSRALPSEDEEGQDDKD 8327
            .|:|:         |.|. :|.:.:|        |....|..|.||.|:..:....|..|:    
  Fly  7921 MRTGKNLLERAPKGDRPV-LDKMLIELKEQWTRVWSKSIDRQRKLEEALLLSGQFSDALGE---- 7980

Human  8328 FYLRGAVGLSDVMIPESPEAYVKLTEN--------AIKNTSGDHSALESQIR------------- 8371
                        ::....:|..:|.||        .::.....|..:|..::             
  Fly  7981 ------------LLDWLKKAKSRLNENGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLKTG 8033

Human  8372 ----------QLGKALDDSRFQIQQTENIIRSKTPTGPELDTSYKGYMKLLGECSSSIDSVKRLE 8426
                      ::|:.||:.:...::.::.:..:   |..|..:.....||.....:..|.:...|
  Fly  8034 RDLERSGNNPEVGRQLDEMQSIWEEVKSAVAKR---GERLQVALVDAEKLNARVQALFDWLDHAE 8095

Human  8427 HKLK------EEEESLPGFVNLH-------------STET--QTAGVID---------------- 8454
            |||:      ::|:.....:::|             .|||  ....:|:                
  Fly  8096 HKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLSI 8160

Human  8455 ---RWELLQAQALSKELRMKQNLQKWQQFNSDLNSIWAWLGDTEEELEQLQRLELSTDIQTIELQ 8516
               |||.::..|:::|.:::|:||..:..:..:..:.|||...|..|..|:..:|..:|..:|..
  Fly  8161 IQQRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLPDEIPPVEKL 8225

Human  8517 IKKLKELQKAVDHRKAIILSINLCSPEFTQADS------------KESRDL-------------- 8555
            |:..||..:....|:..:  ...|.|......:            |.|||.              
  Fly  8226 IEDHKEFMENTARRQNEV--DRACKPRQLPPGARKPSRSGKTPVFKGSRDQGLNARKGSRITPTR 8288

Human  8556 ----QDRLSQMNGRWD-------------RVCSLLEEWRG----------LLQDALM------QC 8587
                :|||.....|:.             |...|..:||.          ||.|.|:      :.
  Fly  8289 DTPDRDRLPHYGPRFSPSTSGPELEFRSPRAKLLWTKWRDVWMLSWERQRLLNDHLLYLKDVERA 8353

Human  8588 QIFTGQVGRP-FLNIKGFHEMSHGLLLMLENIDRRKNEIVPIDSNLDAEILQDHHKQLMQIKHEL 8651
            :.|:....|. ||.... |:.|. |..:...:|:..|.::|.|..:|.         ::..|.:.
  Fly  8354 RNFSWDDWRKRFLKYMN-HKKSR-LTDLFRKMDKDNNGMIPRDVFIDG---------ILNTKFDT 8407

Human  8652 LESQLR-VASLQDMSCQLLVN------AEGTDCLEAK-----EKVHVIGNRLKLL---------- 8694
            ...::: ||.|.|.:.:.|::      |...|..|.|     :|:|....||.:|          
  Fly  8408 SGLEMKAVADLFDRNGEGLIDWQEFIAALRPDWQERKPANDSDKIHDEVKRLVMLCTCRQKFRVF 8472

Human  8695 -LKEVSRHIKELEKLLDVSSSQQDL-----SSWSSADELDTSGSVSPTSGRS------------- 8740
             :.|......:.:||..|...:..:     ..|.:.||...........||:             
  Fly  8473 QVGEGKYRFGDSQKLRLVRILRSTVMVRVGGGWVALDEFLQKNDPCRAKGRTNIELREQFILADG 8537

Human  8741 --------TPNRQKTPRGKCSLSQPGPSVSSPHSRSTKGGSDSSLSEPGPGRSGRGFLFRVLRAA 8797
                    || |:.||....:.|      ||||:.:  |||    |...|..||:|.:.:|...:
  Fly  8538 VSQSMAAFTP-RRSTPNAAATAS------SSPHAHN--GGS----SNLPPYMSGQGPIIKVRERS 8589

Human  8798 LPLQLLLLLLIGLACLVPMSEEDYSC-------ALSNNFARSFHPMLRYT 8840
            :.             .:|||....|.       :||:|......|..|||
  Fly  8590 VR-------------SIPMSRPSRSSLSASTPDSLSDNEGSHGGPSGRYT 8626

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SYNE1XP_006715470.1 CH 28..141 CDD:237981
CH 187..285 CDD:278723 46/97 (47%)
SPEC 1454..1661 CDD:295325 44/224 (20%)
SPEC 1663..1874 CDD:238103 39/220 (18%)
SPEC 2417..2622 CDD:238103 46/239 (19%)
SPEC 2523..2739 CDD:238103 43/232 (19%)
SPEC 2741..2944 CDD:295325 31/215 (14%)
SPEC 3072..3283 CDD:238103 51/252 (20%)
SPEC 3184..3395 CDD:238103 42/241 (17%)
SPEC 3397..3602 CDD:295325 44/244 (18%)
SPEC 3824..4042 CDD:238103 37/241 (15%)
SPEC 4148..4344 CDD:295325 35/219 (16%)
SPEC 4273..4459 CDD:295325 47/305 (15%)
SPEC 4493..4677 CDD:295325 43/233 (18%)
SPEC 4895..5088 CDD:295325 50/267 (19%)
SPEC 5003..5216 CDD:238103 55/301 (18%)
SPEC 5535..>5697 CDD:295325 38/187 (20%)
SPEC 5643..5842 CDD:295325 48/260 (18%)
SMC_prok_B 5944..6730 CDD:274008 174/886 (20%)
SPEC 5971..6196 CDD:295325 57/259 (22%)
SPEC 6808..7030 CDD:295325 47/246 (19%)
SPEC 6926..7137 CDD:238103 40/219 (18%)
SPEC 7046..7244 CDD:238103 43/220 (20%)
SPEC 7173..7361 CDD:295325 46/238 (19%)
SPEC 7365..7567 CDD:238103 46/224 (21%)
SPEC 7469..7680 CDD:238103 38/231 (16%)
SPEC 7793..8008 CDD:238103 52/226 (23%)
SPEC 8012..8222 CDD:238103 42/213 (20%)
SPEC 8476..8709 CDD:238103 60/315 (19%)
KASH <8814..8845 CDD:287506 11/34 (32%)
shotNP_725339.1 SAC6 204..>420 CDD:227401 87/473 (18%)
CH 223..327 CDD:306753 46/120 (38%)
SPEC 471..689 CDD:238103 53/301 (18%)
SPEC 690..866 CDD:238103 48/233 (21%)
SH3 885..922 CDD:327375 9/39 (23%)
SPEC 1047..1250 CDD:238103 38/219 (17%)
SPEC 1153..1390 CDD:238103 63/327 (19%)
PLEC <1498..1526 CDD:197605 4/36 (11%)
Plectin 1949..1981 CDD:307019 8/31 (26%)
DNA_pol3_delta2 <2711..3178 CDD:331068 94/535 (18%)
DUF4775 3026..3357 CDD:330579 72/413 (17%)
SMC_N <4904..5566 CDD:330553 135/701 (19%)
SPEC 5304..5513 CDD:238103 37/212 (17%)
SPEC <5658..5787 CDD:321951 29/130 (22%)
SPEC 5793..6007 CDD:238103 52/230 (23%)
SPEC 6011..6220 CDD:238103 42/225 (19%)
SPEC 6118..6330 CDD:238103 54/291 (19%)
PRK09039 <6279..6441 CDD:332967 41/227 (18%)
SPEC 6443..6660 CDD:238103 46/228 (20%)
SPEC 6663..6878 CDD:238103 55/271 (20%)
SPEC 6880..7087 CDD:238103 46/224 (21%)
SPEC 6986..7196 CDD:238103 48/233 (21%)
SPEC 7196..7417 CDD:238103 34/227 (15%)
SPEC 7314..7526 CDD:238103 41/212 (19%)
SPEC 7528..7747 CDD:238103 48/229 (21%)
SPEC 7749..7968 CDD:238103 43/227 (19%)
SPEC 7973..8181 CDD:238103 31/226 (14%)
EF-hand_7 8373..8437 CDD:316058 14/73 (19%)
GAS2 8450..8522 CDD:128539 12/71 (17%)
Herpes_ICP4_C 8550..>8795 CDD:332854 27/102 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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