DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AFF2 and lilli

DIOPT Version :9

Sequence 1:NP_002016.2 Gene:AFF2 / 2334 HGNCID:3776 Length:1311 Species:Homo sapiens
Sequence 2:NP_001137775.1 Gene:lilli / 33496 FlyBaseID:FBgn0041111 Length:1673 Species:Drosophila melanogaster


Alignment Length:1778 Identity:347/1778 - (19%)
Similarity:569/1778 - (32%) Gaps:647/1778 - (36%)


- Green bases have known domain annotations that are detailed below.


Human     6 FFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNKGDALANR 70
            :.:::::|     |.:|...::||...|.|.:|.:|...|    |||||.::.|    |||   .
  Fly    54 YSQNYNME-----EYERRKRREREKIERQQGIQIDDRETS----LFGEPRRLTE----GDA---E 102

Human    71 VQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNKNEPSFFPEQKNRIIPPHQDNTHPSAP 135
            :...||.:.|.:..:.|.:     |||.: |.|...|.:.:|:..|:.|                
  Fly   103 ITAALGEFFEAREYINNQT-----VGISR-SAPGAGNPRLQPNLAPQAK---------------- 145

Human   136 MPPPSVVILNSTLIHSNRKSKPEWSRDSHNPSTVLASQASGQPNKMQTLTQDQ------SQAKLE 194
                       :|.||     |..:..:..|:.  ||..:..|.:.|...|.|      .||..:
  Fly   146 -----------SLGHS-----PSSASSAAGPTA--ASATTSLPGQQQHYQQQQRPPTYVKQADNK 192

Human   195 DFF----VYPAEQPQIGEVEESN-------PSAKEDSNPNSSG--EDAFKEIFQSNSPEESEFAV 246
            ..:    .||. ||...::..|:       |.....||.|||.  .:|......:::|.....:.
  Fly   193 PPYNGRGGYPG-QPMKNDIPSSSGMAPPRGPPRTSSSNSNSSSVTNNASSGGVPASTPLGPPLST 256

Human   247 QAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMGQQKPTAYVRPMDGQDQAPDISPTLKPSIEF 311
            |.|...  ..|.|.|.:        |.|:..|......|.|..||..||...|......|...:.
  Fly   257 QMPNGR--EKSFLGPPA--------PALHNGTGGRFVPPAASKRPGVGQQPPPPEKDVNKIISDI 311

Human   312 ENSFGNLSFGTLLDGKPSAASSKTKLPKFTIL----QTSEVSLPSDPSCVE--EILREMTHSWPT 370
            .|.| .:...||:...|.|.:.:    .:.:|    |...:.:||.|...|  .::..:.....:
  Fly   312 ANIF-TVQPLTLIAATPHAPTRE----NYNLLAPNRQKYAMDIPSSPPSAEPSSLMTPLFAPITS 371

Human   371 PLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWND--PTTRASTKSVSF-------------- 419
            |:..:.|. ..:.|...:.|..|..:..|..|...:.  ||...:...|:.              
  Fly   372 PIAPLVTT-PPQASQMPLGGATSGTILAGEALAPLHQLPPTMPKAASGVTSPGPVKPLKTEKNHS 435

Human   420 ----KSMLEDDLKLSSDED--------------------------------DLE----------P 438
                .|.||:||:||..||                                ||:          .
  Fly   436 LEKQDSCLENDLELSESEDEQRKKEGRSGGNSSNSSESDSSESGSESSSKNDLQHHPNHQQHHHQ 500

Human   439 VKTLTTQCTATELYQAVEKAKPRNNPVNPPLA-----------------TPQPPPAVQASGG--- 483
            ::....|..||...|.|.:.:.|:.|:....|                 |.....:...|||   
  Fly   501 LQQQQQQQQATMQQQQVLQQQHRSQPLTSNGAQNKKFRHEIIARGSNTITGLLSSSGFGSGGNVG 565

Human   484 -SGSSSESESSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKS---- 543
             :|.:|.:...:.|.|....|:..|.||:.       |.|..:|||.|.::.:|..:|..|    
  Fly   566 PAGVNSNAVVGTGSGSGGTLSSGGSSSNKT-------PSPTESNKWNLSRFFHKPANQTNSESVS 623

Human   544 ----------FICGQNETPMETISLPPPIIQ----------------PMEVQMKVKTNASQVPAE 582
                      .:.|..:...|:|.:...|::                ..|.|::.....|..|..
  Fly   624 PGNVSMKVPGILPGGAQIIPESIDVTTAIVKNEKNDMAMEEGEEEDDDEEQQLRYGGGLSVTPVA 688

Human   583 PKER-------------PLLSLIREKARPRPTQKIPETKALKHKLSTTSETVSQRTIG------- 627
            .|:.             |...:.||.|....:.::.::.......|::|.:.|...:|       
  Fly   689 VKKEAIDAVSEMALGAIPKTQIKRESAETLLSARLSDSGTSASGSSSSSSSSSDSAMGGEVVPMP 753

Human   628 -------------------KKQPKKVEKNTSTDEFTW-------PKPNITSSTPKEKESV----- 661
                               :.||.:.:|...::..|.       ..|......|::|:::     
  Fly   754 GPGETLQLPGVPAAITTVMRVQPTQSQKAPPSNSVTLTPILPLPTSPKQRQKKPRKKKAITSAPI 818

Human   662 ----ELHDPP-------------------------RGRNK-----------------ATAHKPAP 680
                :..:||                         |||.:                 :::....|
  Fly   819 LDSSDDDEPPPKHPGLDHTAVSVQTQPATDTVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGP 883

Human   681 ----RKEPRPNIPLAPEKKKYR-----------GPGKIV-------------------------- 704
                .|:|....|||..:.:.|           .|.|.|                          
  Fly   884 TLTAAKKPLAKTPLAMSRARKREHSSQSSSNGNTPTKKVATPQLVAAPLKPTSNTAGSSSSDEDS 948

Human   705 PKSREFIETDSSTSDSNTD---------------------------------------QEETLQI 730
            ..|.|.....||:|.|:.|                                       :::|.:.
  Fly   949 SSSAESSSKSSSSSSSSDDTETQNTNCRIVKLNKTGAVQKKALLGSGSSSPSSSGSEAEDQTTRS 1013

Human   731 KV---------LPP-----------------C-IISGGNTAKSKEICGASL-------------- 754
            :|         |||                 | ..|||.||    :|.:|.              
  Fly  1014 QVGSGQALAQQLPPYKQLPISQHSQHLSSSDCSSSSGGCTA----VCSSSSGEEDEGRREKERER 1074

Human   755 ----------TLSTLMS--SSGSNNN-----LSISNEE----------------PTFSPIPVMQT 786
                      ||:.:.:  ..|:...     :.:..|:                |..:|..:|..
  Fly  1075 KPKSDKNKINTLTRIFNPKEGGAKKQGQVVIVDLQEEQQQGKLDAAAQPSAPQAPPAAPAAIMAK 1139

Human   787 EILSPLRDHE--------------NLKNLWVKIDLDLLSR---------VPGHSSLHAAPAKPDH 828
            ..::|.:..:              :|.:|..||||..|||         .|...:.|..|     
  Fly  1140 PRMTPTQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPAQQNGHLTP----- 1199

Human   829 KETATK----PKRQTAVTAVEKPAPKGKRKH----------------KPIEVAEKIPEKKQRLEE 873
            |:.||.    |......|   .||.|.|.:|                ||..|.::...|::|..:
  Fly  1200 KDQATNAVHVPNGYAGDT---NPAAKVKHEHPVKPEPELDAGYEAKFKPGNVKQEFQLKQERDRD 1261

Human   874 ATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSPLPEDPP---RRRNVSGNNG 935
                                ..||....|...|.:|.           |.||   |:|:.|.::.
  Fly  1262 --------------------RERERERERERERDRER-----------EQPPGRRRKRSSSSSSS 1295

Human   936 PFGQDKN------------------IAMTGQITSTKPKRTEGKF----------CATFKGISVNE 972
            |:.:.|.                  :.:........|......:          .|....:|...
  Fly  1296 PYKEKKRKKEKADQLQMGKELLPVPVLLPSNNHERMPNHDRLSYDKLQLLHEDAAAVIGDVSAPN 1360

Human   973 GDTPKK--ASSATITVTNTAIATATVTATAIVTTTVTATATATATTTTTTTTISTITSTI-TTGL 1034
            |...||  |.|.........:|.||.. .|:.||..:||||            |.|...: .|.|
  Fly  1361 GSPTKKLLAMSPLPPPPTVTVAPATCN-EAVQTTPPSATAT------------SAIAPPVPATRL 1412

Human  1035 MDSSHLEMTSWAALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNY 1099
            :..|:.:              .:|..|.   ||...| :.::|||...||.||...:.|.:...|
  Fly  1413 IYRSYFD--------------RDVEHPS---DDPRKN-NQFLQEAINRKHAADLERDSFNQVTLY 1459

Human  1100 ADAALSFTECGNAMERDPLEAKSPYTMYSETVELLRY-AMRLKNF----ASPLASDGDKKLAVLC 1159
            .:|.:.|....:||||...| ::..|||.:|:.|::: :.:.:.:    .:.:..:...|:|:|.
  Fly  1460 LEAVVYFLLTADAMERCSSE-QATNTMYKDTLSLIKFISTKFRPYQQQSTTNIQHETHNKVAILS 1523

Human  1160 YRCLSLLYLRMFKLKKDHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKNTPSPVSLNNVSPINA 1224
            .||.||:.|:::||::........||.::|:.....:|        || ||||     ::||.|:
  Fly  1524 LRCQSLISLKLYKLRRKDCRAIINSLTDFFRVGRGDIA--------NG-NTPS-----SISPSNS 1574

Human  1225 MGNCNNGPVT-----IPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENK--EFFGDLDTLMG 1282
            :|:..:|..|     :|..||:|........|.:...:|.||.||:|.|...  :|..:||...|
  Fly  1575 VGSQGSGSNTPPGRIVPPDIHNMLCKQNEFLSYLNSAHELWDQADRLVRTGNHIDFIRELDHENG 1639

Human  1283 PLTQHSSMTNLVRYVRQGLCWLR 1305
            |||.||:|..:.|||:.||..||
  Fly  1640 PLTLHSTMHEVFRYVQAGLKTLR 1662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AFF2NP_002016.2 AF-4 19..1308 CDD:282905 346/1765 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..187 18/92 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 8/33 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..417 8/41 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 457..530 20/93 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..726 40/328 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..867 15/68 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 881..943 13/82 (16%)
lilliNP_001137775.1 AF-4 <1435..1662 CDD:282905 74/241 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147714
Domainoid 1 1.000 131 1.000 Domainoid score I5139
eggNOG 1 0.900 - - E1_28IRS
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 155 1.000 Inparanoid score I4312
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001371
OrthoInspector 1 1.000 - - otm41726
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10528
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4465
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
99.010

Return to query results.
Submit another query.