DRSC/TRiP Functional Genomics Resources

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Protein Alignment AFF2 and aff2

DIOPT Version :10

Sequence 1:NP_002016.2 Gene:AFF2 / 2334 HGNCID:3776 Length:1311 Species:Homo sapiens
Sequence 2:XP_002664429.3 Gene:aff2 / 100330019 ZFINID:ZDB-GENE-110411-190 Length:1269 Species:Danio rerio


Alignment Length:1381 Identity:682/1381 - (49%)
Similarity:877/1381 - (63%) Gaps:182/1381 - (13%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDL--FDFFRDWDLEQQCHYEQDRSALKKREWERRNQEVQQEDDLFSSGFDLFGEPYKVAEYTNK 63
            |||  |||||||:||||||||||||||||:|||||.|||||::||||:||:|||||||    |||
Zfish     1 MDLFEFDFFRDWELEQQCHYEQDRSALKKKEWERRTQEVQQDEDLFSTGFNLFGEPYK----TNK 61

Human    64 GDALANRVQNTLGNYDEMKNLLTNHSNQNHLVGIPKNSVPQNPNNK-NEPSFFPEQKNRIIPPHQ 127
            |||||||||||||||||||.|||:||||:||||||||||||.|..| ::|.||||.:.......|
Zfish    62 GDALANRVQNTLGNYDEMKELLTSHSNQSHLVGIPKNSVPQTPVEKPDQPGFFPEAQRSRPALSQ 126

Human   128 DNTHPSAPMPPPSVVILNSTLIHSNRKSK---PEWSRDSHNPSTVLASQASGQ----PNKMQTLT 185
            ..:|.::..|||:..|..|:::|.::..|   .:||:..|..|.|..:||:.:    .::..:..
Zfish   127 PGSHSTSMPPPPANTIPGSSVMHGHQSKKSRSSDWSQGGHRSSGVQTTQAASRGKHSSHEQTSNR 191

Human   186 QDQSQAKLEDFFVYPAEQPQIGEVEESNPSAKEDSNPNSSGE----------------DAFKEIF 234
            .||.|                           |||:||.:|.                .|..|:.
Zfish   192 HDQDQ---------------------------EDSSPNPNGPTTSSHSSRKQAQAGKGPATAELG 229

Human   235 QSNSPEESEFAVQAPGSPLVASSLLAPSSGLSVQNFPPGLYCKTSMG-QQKPTAYVRPMDGQDQA 298
            ...||.|.:.......|||.::|||  .||||...||.||:||.|.. ||||||||||||||||.
Zfish   230 LGKSPAEQDSCSHGSSSPLASTSLL--PSGLSTPTFPQGLHCKPSSAVQQKPTAYVRPMDGQDQV 292

Human   299 PDISPTLKPSIEFENSFGNLSFGTLLDGKPSAASSKTKLPKFTILQTSEVSLPSDPSCVEEILRE 363
            |:.||.|||.:|....:..:.||.|||.|.|...:|.|:||.|:.|:.|||||:|.:||||||||
Zfish   293 PNDSPELKPPVELVEGYNTVPFGGLLDTKSSTTGTKGKIPKLTLPQSGEVSLPNDSNCVEEILRE 357

Human   364 MTHSWPTPLTSMHTAGHSEQSTFSIPGQESQHLTPGFTLQKWNDPTTRASTKSVSFKSMLEDDLK 428
            ||||||.|||::||.|.:||:.|.||.::|||:|.|:..::.:.|:.:.:||||..|||||||||
Zfish   358 MTHSWPPPLTAIHTPGKAEQTKFPIPSKDSQHVTSGYNAKRCSVPSNKPATKSVPQKSMLEDDLK 422

Human   429 LSSDEDDLEPVKTLTTQCTATELYQAVEKAKPRNNPVNPP--LATPQPPPAVQASGGSGSSSESE 491
            :||||:|.:               ||.||.|||:..:|.|  .|......|..:||.||||||||
Zfish   423 ISSDEEDND---------------QAAEKPKPRSTALNLPGSTAVRSSEAAGHSSGASGSSSESE 472

Human   492 SSSESDSDTESSTTDSESNEAPRVATPEPEPPSTNKWQLDKWLNKVTSQNKSFICGQNETPMETI 556
            ||||||||:|||::|||.|.|.|.|||||||   :|||||||:.||...||:.|..|.::.....
Zfish   473 SSSESDSDSESSSSDSECNRASRAATPEPEP---SKWQLDKWIKKVNPHNKALINTQADSHGLNS 534

Human   557 SLPPPIIQPMEVQ-------MKVKTNASQVPAEPKERPLLSLIREKARPRPTQKIPETKALKHKL 614
            |      ||.|.|       .|.|.:.:..||:||||.|||.|||||:|:..||.|::|:.|.|.
Zfish   535 S------QPDESQTSENQSYSKSKPSTALAPADPKERTLLSPIREKAKPKAGQKAPDSKSTKVKS 593

Human   615 STTSETV-SQRTIGKKQPKKVEKNTSTDEFTWPKPNITSSTPKEKESVELHDPPRGRNKATAHKP 678
            ..:.|.. .:|:.|||||||||:::|::|..||:|..:||||||||...| :||:.|.|....|.
Zfish   594 PASVELAPPRRSTGKKQPKKVERSSSSEEHNWPRPGNSSSTPKEKEPPPL-EPPKPRGKGPVVKT 657

Human   679 APRKEPR--------PNIPLAPEKKKYRGPGKIVPKSREFIETDSSTSDSNTDQEETLQIKVLPP 735
            |||||||        .||...|:|||:|||.||:|||:|||||:||:|:.::|.||..::::  |
Zfish   658 APRKEPRTTTTSTAPTNIAPVPDKKKHRGPNKIIPKSKEFIETESSSSECHSDPEELTKVQL--P 720

Human   736 CIISGGNT--AKSKEICGASLTLSTLMSSS-------GSNNNLSISNEEPTFSPIPVMQTEILSP 791
            |  .|.||  .|||:.....|::|:|.|:|       |:::.|    ||..|||||::|.|:|||
Zfish   721 C--PGPNTLSLKSKDCNSNILSVSSLTSTSSTSIPDPGASDLL----EEHLFSPIPIVQNELLSP 779

Human   792 LRDHENLKNLWVKIDLDLLSRVPGHSSLHAAPAKPDHKETATKPKRQTAVTAV--EKPAPKGKRK 854
            |||.|::|:|||||:|..|||:||.......|.|.:.:|.:.|.:||.:..::  ||...|.|||
Zfish   780 LRDFEDIKSLWVKIELSFLSRIPGQDPPEPPPTKAECREVSVKHRRQQSPASIPAEKNPSKSKRK 844

Human   855 HKPIEVAEKIPEKKQRLEEATTICLLPPCISPAPPHKPPNTRENNSSRRANRRKEEKLFPPPLSP 919
            ||..........||.||::.|  .||||||||...||..:|::  |.::..|:|::||.||.|||
Zfish   845 HKSEHCDVMSGGKKLRLDKDT--LLLPPCISPIHNHKVSSTKD--SLKKQPRKKDDKLLPPLLSP 905

Human   920 LPEDPPRRRNVSGNNGPFGQDKNIAMTGQITSTKPKRTEGKFCATFKGISVNEGDTPKKASSATI 984
            |..:|..|                          |:|:..  |::..    .||        :|.
Zfish   906 LSVEPVGR--------------------------PRRSSE--CSSLS----QEG--------STS 930

Human   985 TVTNTAIATATVTATAIVTTTVTA----TATATATTTTTTTTISTITSTITTGLMDSSHLEMTSW 1045
            |:.|...::.|:.|::..:::.::    .....|.:.:.|:|.....|..:.|...:...:...|
Zfish   931 TIPNNLPSSRTIPASSSSSSSSSSHKHRKGENKAFSHSKTSTEEDSHSKPSGGFHGNGQSDADLW 995

Human  1046 AALPLLSSSSTNVRRPKLTFDDSVHNADYYMQEAKKLKHKADALFEKFGKAVNYADAALSFTECG 1110
            :....|:......|||||||:.:||:||||||||||||||||||.:||||||||||.||||.|||
Zfish   996 SNPSALTMEHMEPRRPKLTFNSTVHSADYYMQEAKKLKHKADALMDKFGKAVNYADGALSFIECG 1060

Human  1111 NAMERDPLEAKSPYTMYSETVELLRYAMRLKNFASPLASDGDKKLAVLCYRCLSLLYLRMFKLKK 1175
            |||||||||||||||||||||||:|||||||||.|..|:..:|||||||.|||||||||||||||
Zfish  1061 NAMERDPLEAKSPYTMYSETVELIRYAMRLKNFTSHSATIAEKKLAVLCNRCLSLLYLRMFKLKK 1125

Human  1176 DHAMKYSRSLMEYFKQNASKVAQIPSPWVSNGKN--TPSPVSLNNVSPIN-------AMGNCN-N 1230
            ||||||||||||||| |::|.:|.||||.:|||:  ||||:|| :.||::       |||:.: :
Zfish  1126 DHAMKYSRSLMEYFK-NSAKSSQAPSPWGANGKSTGTPSPMSL-SPSPVSSVSSSAGAMGSSSAS 1188

Human  1231 GPVTIPQRIHHMAASHVNITSNVLRGYEHWDMADKLTRENKEFFGDLDTLMGPLTQHSSMTNLVR 1295
            |.|.||||||||||||||||:|:||.||||:.||||.:|::|||.:||::|.|||||||||.|||
Zfish  1189 GSVAIPQRIHHMAASHVNITNNILRSYEHWETADKLAQESQEFFVELDSVMEPLTQHSSMTELVR 1253

Human  1296 YVRQGLCWLRIDAHLL 1311
            |:||||.|||::||||
Zfish  1254 YIRQGLHWLRLEAHLL 1269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AFF2NP_002016.2 AF-4 18..535 CDD:461550 271/543 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..187 34/100 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..417 15/39 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 457..530 44/74 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..726 81/160 (51%)
AF4_int 801..815 CDD:436798 9/13 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..867 14/50 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 881..943 22/61 (36%)
AF-4_C 1056..1311 CDD:465894 194/264 (73%)
aff2XP_002664429.3 None

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