Protein Alignment VPS39 and Vps39

DIOPT Version :10

• Sequence 1: XP_011519705.1
• Gene: VPS39 / 23339
• HGNCID: 20593
• Length: 907
• Species: Homo sapiens
• Sequence 2: NP_650702.1
• Gene: Vps39 / 42192
• FlyBaseID: FBgn0038593
• Length: 876
• Species: Drosophila melanogaster
• Alignment Length: 904
• Identity: 316/904 - (34%)
• Similarity: 485/904 - (53%)
• Gaps: 105/904 - (11%)

Human     1 MHDAFEPVPILEKLPLQIDCLAAWEEWLLVGTKQGHLLLYRIRKDVVPADVASPESGSCNRFEVT 65
            ||.|:....|| |..:||:.:||:...:::||:.|.|::|.:          ..|:|      |.
  Fly     1 MHQAYSVHSIL-KQGVQIESIAAYGNHVILGTRSGQLIMYSV----------DEETG------VD 48

Human    66 LEKSNKNFSKK-IQQIHVVSQFKILVSLLENNIYVHDL----LTFQQITTVSKAKGASLFTCDLQ 125
            :...|||||:| |.|:.|::...:|..|.:..:.|.|:    ..|..:.:....||.:|||.|:.
  Fly    49 MRMFNKNFSRKPITQMEVIASENLLFVLTDLQVQVCDIRRIESNFAFMHSAPDTKGCTLFTMDVD 113

Human   126 --HTETGE--EVLRMCVAVKKKLQLYFWKDREFHELQGDFSVPDVPKSMAWCENSICVGFKRDYY 186
              .:.||.  .|:|:|.|::::|..:|||:.:.:.|:....:.|||:::.|..:::|||||.:|.
  Fly   114 TPKSTTGRVATVIRVCCAIRRRLVFFFWKEDKLNSLELIIELSDVPRTLCWVGHAVCVGFKDEYV 178

Human   187 LIRVDGKGSIK-ELFPTGKQL--EPLVAPLADGKVAVGQDDLTVVLNEEGICTQKCALNWTDI-P 247
            :..:.||...| .||.|...:  :|.:..:.:..:.:.:|...||::...........|.||: |
  Fly   179 VYDISGKAPKKHNLFLTSSSISRDPCICLIRNNMLGISKDSYLVVVDPSQYKESDGINNSTDVRP 243

Human   248 VAMEH------------------QPPYIIAVLPRYVEIRTFEPR-LLVQSI-ELQRPRFITSGGS 292
            .||:.                  ..|:.:..:...:|:|:...: .|||:| |||:.:|:.....
  Fly   244 AAMDSNSSLTPLLWSSPLLDLVWDEPFAVGRVNNAIEVRSLVGKDTLVQTIPELQKTKFLVHADK 308

Human   293 NIIYVASNHFVW--RLIPVPMATQIQQLLQDKQFELALQLAEMKDDSDSEKQQQIHHIKNLYAFN 355
            ..|:.|:...:|  |::.:|:  |.|||||.|:|:||::|.::.|:..:::.|.|..|..|||..
  Fly   309 GTIFAAATSELWCIRMVEIPI--QRQQLLQQKKFQLAIELTQISDEPAADRAQTIRQIHMLYAKE 371

Human   356 LFCQKRFDESMQVFAKLGTDPTHVMGLYPDLLPTDYRKQLQYPNP-----------LPVLSGAEL 409
            ||..|.|..:|:.|.|...||..|:.|:|:|:|.        |.|           .|.|..::|
  Fly   372 LFTNKEFSAAMKEFEKAAIDPYDVIRLFPNLVPE--------PKPGTEDVTVPTSSTPALEDSDL 428

Human   410 EKAHLALIDYLTQKRSQLVKKLNDSDHQSSTSPLMEGTPTIKSKKKLLQIIDTTLLKCYLHTNVA 474
            |.|:||||:||...|.:.|.||.|               |..|.|.||:|||||||||||.||.:
  Fly   429 ENAYLALIEYLAWARQREVVKLRD---------------TKSSSKSLLEIIDTTLLKCYLQTNDS 478

Human   475 LVAPLLRLENNHCHIEESEHVLKKAHKYSELIILYEKKGLHEKALQVLVDQSKKANSPLKGHERT 539
            ||||||||  |.||:||||..|||.:|.|||||||:.||.|::||::|.:|:....|.|:|.:||
  Fly   479 LVAPLLRL--NQCHLEESEKTLKKHNKISELIILYQMKGKHKEALKLLREQASIEGSVLQGRKRT 541

Human   540 VQYLQHLGTENLHLIFSYSVWVLRDFPEDGLKIFTEDLPEVESLPRDRVLGFLIENFKGLAIPYL 604
            ::|||.||.::|.|||.::.|||.|.||:||.|||::|.|||||||.:||.|.|...|.|.||||
  Fly   542 IRYLQELGGDHLPLIFEFADWVLNDNPEEGLTIFTDELIEVESLPRAKVLDFFISKHKALVIPYL 606

Human   605 EHIIHVWEETGSRFHNCLIQLYCEKVQGLMKEYLLSFPAGKTPVPAGEEEGELGEYRQKLLMFLE 669
            ||:|..|::..:..||.|::.|.||||.|:.:.           ..|||..||...|.||...||
  Fly   607 EHVITEWKDGNTLLHNVLLKQYREKVQRLLAQQ-----------EKGEEVPELIPMRAKLYKMLE 660

Human   670 ISSYYDPGRLICDFPFDGLLEERALLLGRMGKHEQALFIYVHILKDTRMAEEYCHKHYDRNKDGN 734
            .|:.|.|.||:.:||.:.|||||||:|||:.||:..|.||:|:|.|...|..|...||..    :
  Fly   661 ESNDYSPDRLLEEFPTNILLEERALILGRLKKHDNVLSIYIHVLGDVAKATAYAEAHYKE----D 721

Human   735 KDVYLSLLRMYLSPPSIHCLGPIKLELLEPKANLQAALQVLELHHSKLDTTKALNLLPANTQIND 799
            |.::.:|::..|.||:......:.|.....:.|.:.||::|..|.:::|..:....||.:..:..
  Fly   722 KHIFHTLIKCILIPPTQPLYDGVPLHPDFSQVNREVALEILNTHATRIDPFEIFEHLPDDMPMPQ 786

Human   800 IRIFLEKVLEENAQKKRFNQVLKNLLHAEFLRVQEERILHQQVKCIITEEKVCMVCKKK 858
            :..:|||.:.:....|...|::...|.||..|::......:.:...:.|..||..|||:
  Fly   787 LEKYLEKSIRKMMADKHEMQMMCGFLEAESTRLENALEEQRNISFELNESSVCSECKKR 845

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS39	XP_011519705.1	CNH	24..290	CDD:470577	76/298 (26%)
		Vps39_1	460..562	CDD:371008	60/101 (59%)
		Clathrin	595..746	CDD:459884	60/150 (40%)
		Vps39_2	772..862	CDD:402126	21/87 (24%)
Vps39	NP_650702.1	CNH	24..304	CDD:470577	76/295 (26%)
		Vps39_1	464..564	CDD:371008	60/101 (59%)
		Vps39_2	759..868	CDD:402126	21/87 (24%)