DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NEDD4L and Nedd4

DIOPT Version :9

Sequence 1:XP_006722489.1 Gene:NEDD4L / 23327 HGNCID:7728 Length:1019 Species:Homo sapiens
Sequence 2:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster


Alignment Length:1059 Identity:487/1059 - (45%)
Similarity:628/1059 - (59%) Gaps:170/1059 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    15 DEGESRILRVKVVSGIDLAKKDIFGASFCSIAVELFFGRDIRKITKCESDNSNDPYVKLSLYVAD 79
            |.|:|..||:.|::|..||||||||||                          ||||::.|...:
  Fly    65 DSGDSCHLRIVVLTGQSLAKKDIFGAS--------------------------DPYVRIDLNTIN 103

Human    80 ENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTE 144
            .:..:..|.|||.||||||.|||||.|||.||.|:|:|:||||||||||||||.|::.|.:||||
  Fly   104 GDINIDSVLTKTKKKTLNPTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTE 168

Human   145 DPTM---ERPYTFKDFLLRPR---SHKSRVKGFLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVV 203
            ....   |:.||     ||||   ..|||:||.||:..|::.:...|.|.:|...|.   .||.|
  Fly   169 QEGRTIGEQSYT-----LRPRRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDG---EWEHV 225

Human   204 DSNDSASQHQEELPPP-----PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNI 263
            ::.::.....:..|.|     .||.||||:.|..||||||||..|||||.||:::: |..|.:..
  Fly   226 EATNAGETSAQPHPFPTGGHDALPAGWEERQDANGRTYYVNHTARTTQWDRPTVLN-SHSSQSTD 289

Human   264 RQINQEAAHRRFRSRRHISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPAS----- 323
            .|:..:     |:.|.|||.|    .:|.|...:.....|.|.|  .::.|||..|..|:     
  Fly   290 DQLASD-----FQRRFHISVD----DTESGRSADSISHNSIEDN--NNAAGLAYTPKTAATSSAP 343

Human   324 PGSRTSPQELSEELSRRLQI------TPDSNGEQFSSL----IQREPSSRLRSCSVTDAVAEQGH 378
            |.:.|:...:..:::.:.:.      |.|.....::||    ..|:|.        ..|.:.|..
  Fly   344 PNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPE--------ISATSLQND 400

Human   379 LPP----PSA-------PAGRARSSTVTGGEEPTPSVAYVHTTPGLPSGW-EERKDAKGRTYYVN 431
            |.|    |..       |..|..:..:.||                 :|| :||:..:.:.:...
  Fly   401 LRPVREAPGVPDIAITNPFTRRAAGNMAGG-----------------AGWQQERRRQQMQLHIQQ 448

Human   432 HNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAKDSPVRRAV 496
            |..|.....:..:.|..|          :...|||.|                 |.:.....|..
  Fly   449 HQQRQQQQQQNRILLDVD----------HRQQEPQHR-----------------GQRHQQQHRPS 486

Human   497 KDTLSNPQSPQPSPYNSPK-------------PQHKVT---QSFLPPGWEMRIAPNGRPFFIDHN 545
            .:...:..|..||..::|.             |..:.|   :..|||.|.|::|||||.|||||.
  Fly   487 NEDTDHTDSHNPSDISAPSTRRNSEEDNAAVPPMEQNTGGEEEPLPPRWSMQVAPNGRTFFIDHA 551

Human   546 TKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGWEERIHLDGRTFYIDHSSQVLCGENDTRESV 610
            ::.|||.|||......|.::|....:||||||.|||||:|.|||.|||||               
  Fly   552 SRRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEGWEERVHTDGRVFYIDH--------------- 601

Human   611 PSYDSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEES 675
               :::.||||||||.||.|.|.||||||::||||:||:..::||.::||:||:::.|.:|.|:|
  Fly   602 ---NTRTTQWEDPRLSNPNIAGQAVPYSRDYKQKYEYFKSHIRKPTNVPNKFEIRIRRTSILEDS 663

Human   676 YRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 740
            ||.|.||.:.|:||.:||:|||.|.||||||:|||||:||||||||||||||||||.||||||||
  Fly   664 YRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQIN 728

Human   741 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLK 805
            ..||||||:|||||.||||:||:||:||||||.|||||||||||.|.|.|.||||||:||||||.
  Fly   729 NGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLM 793

Human   806 WILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNA 870
            ||.||||..|:|.||:||:.|||..|.:|||.|:.|.||||||.|||.|||:||||.||::||::
  Fly   794 WIKENDPRILELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSS 858

Human   871 FLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMD 935
            ||:||..::|::|||||||:||||||||:.::||.|||::::||..|..||.:|||||:|||...
  Fly   859 FLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFWRAVLSFS 923

Human   936 AEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFED 1000
            .|.|.|||||||||||||||||.|||||||||:||||:||:|...||||||||||||||||.:..
  Fly   924 NEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQ 988

Human  1001 LREKLLMAVENAQGFEGVD 1019
            |::||:.|:|.:|||.|||
  Fly   989 LKDKLIKAIEGSQGFAGVD 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NEDD4LXP_006722489.1 C2_NEDD4_NEDD4L 21..179 CDD:175999 77/163 (47%)
WW 224..250 CDD:278809 18/25 (72%)
WW 413..442 CDD:278809 6/29 (21%)
WW 526..556 CDD:238122 19/29 (66%)
WW 575..625 CDD:197736 23/49 (47%)
HECTc 662..1016 CDD:238033 245/353 (69%)
HECTc 686..1015 CDD:214523 233/328 (71%)
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 77/163 (47%)
WW 248..277 CDD:278809 20/28 (71%)
WW 531..560 CDD:278809 18/28 (64%)
WW 581..613 CDD:197736 23/49 (47%)
HECTc 650..1003 CDD:238033 244/352 (69%)
HECTc 674..1003 CDD:214523 233/328 (71%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 471 1.000 Domainoid score I454
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H86986
Inparanoid 1 1.050 884 1.000 Inparanoid score I398
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49869
OrthoDB 1 1.010 - - D142537at33208
OrthoFinder 1 1.000 - - FOG0000080
OrthoInspector 1 1.000 - - otm41627
orthoMCL 1 0.900 - - OOG6_100256
Panther 1 1.100 - - O PTHR11254
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2273
SonicParanoid 1 1.000 - - X1682
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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