DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAN2B2 and LManII

DIOPT Version :9

Sequence 1:NP_056089.1 Gene:MAN2B2 / 23324 HGNCID:29623 Length:1009 Species:Homo sapiens
Sequence 2:NP_609408.1 Gene:LManII / 34437 FlyBaseID:FBgn0027611 Length:1080 Species:Drosophila melanogaster


Alignment Length:1192 Identity:309/1192 - (25%)
Similarity:483/1192 - (40%) Gaps:334/1192 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    11 APLLLLRPP----GVQSAGP-----IRAFVVPHSHMDVGWVYTVQE--------SMRAYAANVYT 58
            |.|..::|.    |.||..|     :...:|.|:|.||||:.||.:        ..:|....:..
  Fly    22 ADLRSIQPKASQCGYQSCHPTKPNMLNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIID 86

Human    59 SVVEELARGQQRRFIAVEQEFFRLWWDGVASDQQKYQ--VRQLLEEGRLEFVIGGQVMHDEAVTH 121
            ||||.|.|..::|||.||..||..||   ...:.|.|  |:.|:|:|||||:.|...|:|||.||
  Fly    87 SVVEALLRDPEKRFIYVESAFFFKWW---KEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTH 148

Human   122 LDDQILQLTEGHGFLYETFGI--RPQFSWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAM 184
            ....|.|.:.|...|.:|||.  ||:..|.:||||.|....::||..||:.....|:||..|...
  Fly   149 YQSVIDQFSWGLRLLNDTFGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDER 213

Human   185 QEARGLQFVWRGSPSLSERQEIFTHIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPQDGVYPN 249
            ...:..:.:|.||.:|.|..::|:..: ..:|..|        .||.:: :.....|..||.:  
  Fly   214 LMTKNAEMIWHGSANLGEEADLFSGAL-YNNYQAP--------DGFCFD-ILCNDAPIIDGKH-- 266

Human   250 MSEPVTPANINLYAEALVANVKQR-----------AAWFRTPHVLWPWGCDKQFFNASVQFANMD 303
                 :|.|          |||:|           :.::||.:::...|.|..:..|.|.:.|:|
  Fly   267 -----SPDN----------NVKERIDTFLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLD 316

Human   304 PLLDHINSHAAE-LGVSVQYATLGDYFRALHALNVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSS 367
            .|:.:.|...|. ..:::.|:|...|.::||...:||..:. .||.||:::|...|||::|||.:
  Fly   317 KLIRYGNERQANGSNINLLYSTPSCYLKSLHDAGITWPTKS-DDFFPYASDPHAYWTGYFTSRPT 380

Human   368 LKGLARRASALLYAGESMFTRYLWPAPRGHLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVR 432
            ||...|..:..|...:.:..  |.|......||     .|..:|..:..:||||||||||..||.
  Fly   381 LKRFERDGNHFLQVCKQLSA--LAPKKPEEFDP-----HLTFMRETLGIMQHHDAITGTEKEKVA 438

Human   433 DMYATHLASGMLGMRKLMASI--VLDELQPQA--------------------------PMAASSD 469
            ..||..::   :..|...|:.  .|::|..|:                          |::.::|
  Fly   439 LDYAKRMS---VAFRACGATTRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEAND 500

Human   470 AGPAGHFA-SVYNPLAWTVTTIVTLTVGFPGVRVTDEAG-------HPVPSQI-----QNSTETP 521
                 .|| ::|||||.||...|.:.|.:...|:.|..|       .|:|..:     :|||   
  Fly   501 -----RFALTLYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNST--- 557

Human   522 SAYDLLIL-TTIPGLSYRHYNIRPTAGAQEGTQEPAATVASTLQFGRRLRRRTSHAGRYLVPVAN 585
            :.|:::.| |.||.|.||.|.:......:..|:..|            |.:|||.     |.|..
  Fly   558 AKYEIVFLATNIPALGYRTYYVEKLDSTEGNTRSKA------------LPKRTSS-----VTVIG 605

Human   586 DCYIVLLDQDTNLMHSIWERQSNRTVR-VTQEFLEYHVNGDVKQGPISDN----------YLFTP 639
            :.:| .|..|||...|  |..::...| |:||||.|       :|.:.:|          |:|.|
  Fly   606 NSHI-QLGFDTNGFLS--EVTADGLTRLVSQEFLFY-------EGAVGNNAEFLNRSSGAYIFRP 660

Human   640 GKAAVP-AWEAVEMEIVAGQLVTEIRQYF--YRNMTAQNY---TYAIRSRLTHVPQGHDGELLCH 698
            .:..:. |.:.||:|:..|.||.|:.|.|  :.:...:.|   :||                   
  Fly   661 NENKIHFATDQVEIEVYKGDLVHEVHQKFNDWISQVVRVYNKDSYA------------------- 706

Human   699 RIEQEYQAGPLELN----REAVLRTSTNLNSQQVIYSDNNGYQMQRR------PYVSYVNNSIAR 753
              |.|:..||:.::    :|.:.|.::::.|..:..:|:||.:|.:|      .:...:|.::|.
  Fly   707 --EFEWLVGPIPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAG 769

Human   754 NYYPMVQSAFMEDGKSRLVLLSERAHGISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTSVVH 818
            ||||:.....:||..:|:.:|::||.|.||..:|.:|:|:||||..  |...|....||:|    
  Fly   770 NYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLK--DDAFGVGEALNET---- 828

Human   819 PVLWLLLGSWSLTTALRQRSALALQHRPVVLFGDLAGTAPKLPGPQQQEAVTLPPNLHLQILS-- 881
                            .....|..:.:..:.||.          ...:|.|:|.....|..|.  
  Fly   829 ----------------EYGDGLIARGKHHLFFGK----------STDREGVSLKGIERLTQLEKL 867

Human   882 IPGWRYSSNHTEHSQN-------------------------LRKGHRGEAQADLRRVLLRLYHLY 921
            :|.|::.||..::|.:                         |...|..:       :|:|..|:.
  Fly   868 LPTWKFFSNMEDYSADEWQTAFTNIFSGISLVLPKPVHLLTLEPWHENQ-------LLVRFEHIM 925

Human   922 EVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWDLSMLHRWSWRTGP------------- 973
            |.|||...||||..|::.||.|. .|..:.|.:|.|...|....|..:...|             
  Fly   926 ENGEDASYSQPVQFNVKNVLSAF-DVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNTYATFSQ 989

Human   974 ---------------------------------GRHRGDTTS---------PSRPPGGP------ 990
                                             .|.|.:|.:         .|:...||      
  Fly   990 PAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRIRRETETRQEKKDEGRSSKSTEGPYNSFKS 1054

Human   991 -------IITVHPKEIRTFFIH 1005
                   ||.:.|.|||||.::
  Fly  1055 DSSNQEYIIELSPMEIRTFIVY 1076

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAN2B2NP_056089.1 GH38N_AMII_Epman_like 27..352 CDD:212122 106/348 (30%)
Alpha-mann_mid 358..439 CDD:214875 30/80 (38%)
Glyco_hydro_38C 581..1002 CDD:285047 122/542 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 972..991 7/86 (8%)
LManIINP_609408.1 GH38N_AMII_LAM_like 47..323 CDD:212121 93/305 (30%)
Alpha-mann_mid 370..445 CDD:214875 30/81 (37%)
Glyco_hydro_38C 502..957 CDD:285047 139/545 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1959
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D201312at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11607
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.920

Return to query results.
Submit another query.