Protein Alignment MAN2B2 and LManIII

DIOPT Version :10

• Sequence 1: NP_056089.1
• Gene: MAN2B2 / 23324
• HGNCID: 29623
• Length: 1009
• Species: Homo sapiens
• Sequence 2: NP_609250.2
• Gene: LManIII / 34203
• FlyBaseID: FBgn0032066
• Length: 1003
• Species: Drosophila melanogaster
• Alignment Length: 1096
• Identity: 280/1096 - (25%)
• Similarity: 446/1096 - (40%)
• Gaps: 250/1096 - (22%)

Human    27 IRAFVVPHSHMDVGWVYTVQESMRAYAAN-----------VYTSVVEELARGQQRRFIAVEQEFF 80
            |...:|||||.|:||:.||.:   .|..|           ::.:||.||::..:||||.||..||
  Fly    37 INIHLVPHSHDDLGWLKTVDQ---YYYGNKHNIQHAGVQYIFDTVVAELSKDSRRRFIQVETGFF 98

Human    81 RLWWDGVASDQQKYQVRQLLEEGRLEFVIGGQVMHDEAVTHLDDQILQLTEGHGFLYETFGI--R 143
            ..||:. .|:.:|..|:.|:.||||||..|...|:|||..:....|.|...|..||.:.||:  |
  Fly    99 AKWWED-QSETKKKLVKTLVNEGRLEFTGGAWSMNDEAAVNYQSVIDQFAVGLKFLNDNFGVCGR 162

Human   144 PQFSWHVDPFGASATTPTLFALAGFNAHLGSRIDYDLKAAMQEARGLQFVWRGSPSLSERQEIFT 208
            |:..|.:|.||.|....::||...|:....:|:|.:.|....:..||:.||..|.:| |..:.||
  Fly   163 PRVGWQIDAFGHSREQASMFAQMAFDGQFFARMDQNDKNKRVDNLGLEMVWDASETL-EEMDFFT 226

Human   209 HIMDQYSYCTPSHIPFSNRSGFYWNGVAVFPKPPQDG-VYPNMSEPVTPANINLYAEALVANVKQ 272
            .::  |::       :|...||.::.:.. ..|..|| .|.|        |:....:..:.....
  Fly   227 GML--YNH-------YSAPPGFCFDSLCQ-DDPIIDGKSYDN--------NVKSRVDDFLNYASN 273

Human   273 RAAWFRTPHVLWPWGCDKQFFNASVQFANMDPLLDHINS-HAAELGVSVQYATLGDYFRALHAL- 335
            .|.::|:.|::.|.|.|.|:.||.:.:.|||.|:.::|. .|:....::.|:|.|.|..:||..
  Fly   274 LAGYYRSNHIMVPMGDDFQYENAYMNYKNMDKLIKYVNERQASGSKYNIFYSTAGCYLNSLHKSL 338

Human   336 ----NVTWRVRDHHDFLPYSTEPFQAWTGFYTSRSSLKGLARRASALLYAGESMFTRYLWPAPRG 396
                |.|      .||||:|.|....||||:|||.:.|...|..:.:|...:.:...........
  Fly   339 QSFPNKT------QDFLPHSHEAKSFWTGFFTSRPTQKRFERDGNHILQVAKQLSVLADLSGEEQ 397

Human   397 HLDPTWALQQLQQLRWAVSEVQHHDAITGTESPKVRDMYATHLASGMLGMRKLMASIVLDEL--- 458
            |.|       |..||..::.:||||||||||..:|.:.|...|...:||    .|:...|.|
  Fly   398 HKD-------LDYLRQIMAVMQHHDAITGTEKQEVSNDYDRLLYDAILG----GANTARDALRVL 451

Human   459 --QPQAPM----------AASSDAGPAGHFASVYNPLAWTVTTIVTLTVGFPGVRVTDEAGHPVP 511
              ||....          .|.:.........::|||||.|.|..|.:.|.....:||||.|..|.
  Fly   452 TNQPNGEFQSCLKLNISECAFTKENADDFMVTLYNPLAHTSTQYVRVPVKEDSYQVTDEKGGLVA 516

Human   512 SQIQNSTETPSAYDLLILTTIPGLSYRHYNIRPTAGAQEGTQEPAATVASTLQFGRRLRRRTSHA 576
            |::     .|..:::|      .|.:|:          ..||......||           .:..
  Fly   517 SEL-----VPVPWEVL------SLEFRN----------NDTQHELVFKAS-----------VNKI 549

Human   577 GRYLVPVANDCYIVLLDQDTNLMHSIWERQSNRTVRVTQEFLEYH-------------------- 621
            ..|.:...:....|.:..:|....|:.|.:||  |:|.:.|.:.|
  Fly   550 ATYFIKKIDKTTEVDITVNTQTEQSVNEEESN--VKVPKRFKKVHSLKTDLETLDDQETIVQNSL 612

Human   622 ----------------VNG---DVKQ------GPISDNYLFTPGKAAVPAWEAVEMEIVAGQLVT 661
                            :||   |:.|      ...|.:|:|..........:|.:..:..|:.|.
  Fly   613 IKLVIDNNTGRLKTVEMNGVSEDIDQTFGMYKTARSCHYIFRQDADLELVEDAFDFTVYDGESVK 677

Human   662 EIRQYFYRNMTAQNYTYAIRSRLTHVPQGHDGELLCHRIEQEYQAGPL----ELNREAVLRTSTN 722
            |:.|:             :...::.|.:.::|   .:|:|.|:..||:    ||.:|.|....:.
  Fly   678 EVHQH-------------VNEWISQVIRIYEG---VNRVEFEWLVGPVPIDDELGKEIVTIFKSG 726

Human   723 LNSQQVIYSDNNGYQMQRR---------PYVSYVNNSIARNYYPMVQSAFMEDGKSRLVLLSERA 778
            ::|..|.|:|:||.:|.||         |.:|  ...::.||||:.....::|...|:|||::|:
  Fly   727 ISSGGVFYTDSNGREMMRREKDKREDFSPDLS--EQPVSGNYYPVTSRMALQDSSKRMVLLNDRS 789

Human   779 HGISSQGNGQVEVMLHRRLWNNFDWDLGYNLTLNDTS-----VVHPVLWLLLGSWSLTTALRQRS 838
            .|.:|..:|::|:|||||  :.|....|....:|:..     :....|:|.|.:........:|.
  Fly   790 QGGASLEDGRLEMMLHRR--HIFADGSGAAEAINEQQFGKGLIARGKLFLYLNAIEDGATASERV 852

Human   839 ALALQHRPVVLFGDLAGTAPKLPGPQQQEAVT--------LPPNLHLQILSIPGWRYSSNHTEHS 895
            |....|.|...|...:...        |..||        ||.::||..|.    .||.:
  Fly   853 AEKEIHLPFWKFFSKSNNI--------QSDVTKTLSDFNDLPQSVHLLTLE----PYSKD----- 900

Human   896 QNLRKGHRGEAQADLRRVLLRLYHLYEVGEDPVLSQPVTVNLEAVLQALGSVVAVEERSLTGTWD 960
                            .:||||.:..:..|..|    |:.::..:...||. :.:.|.:|.|...
  Fly   901 ----------------EILLRLENFLDQTEGNV----VSFSIRQIFDDLGG-LEIRETTLDGNLP 944

Human   961 LSMLHRWSWR---TGPGR---------HRGDTTSPSRPPGGPIITVHPKEIRTFFI 1004
            ||.:.|..:.   :||..         |:......::......:|:.|.:||||.|
  Fly   945 LSDMKRLKFHHDGSGPSHSVPEYFTSLHKPLAADKTQDASEFSVTLKPMQIRTFII 1000

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAN2B2	NP_056089.1	PLN02701	27..797	CDD:178304	233/862 (27%)
		GH38N_AMII_Epman_like	27..352	CDD:212122	108/344 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..991		3/27 (11%)
LManIII	NP_609250.2	PLN02701	20..820	CDD:178304	236/876 (27%)
		GH38N_AMII_LAM_like	37..311	CDD:212121	94/296 (32%)