Protein Alignment TRIM2 and trim2

DIOPT Version :10

• Sequence 1: NP_001362417.1
• Gene: TRIM2 / 23321
• HGNCID: 15974
• Length: 802
• Species: Homo sapiens
• Sequence 2: NP_001005680.1
• Gene: trim2 / 448181
• XenbaseID: XB-GENE-942459
• Length: 760
• Species: Xenopus tropicalis
• Alignment Length: 791
• Identity: 688/791 - (86%)
• Similarity: 727/791 - (91%)
• Gaps: 47/791 - (5%)

Human    28 MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQ 92
            |||||:|||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||
 Frog     1 MASEGSNIPSPVVRQIDKQFLICSICLDRYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQ 65

Human    93 TSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNRQSFAV 157
            |||||||||:|||||||||||||||||:|.:..|||||||||:||||||||||||||||
 Frog    66 TSILPEKGVSALQNNFFITNLMDVLQRSPDNGIEESSILETVSAVAAGKPLSCPNHDGN------ 124

Human   158 VPRLVSNPWPQVILPPWPSKVLGLQVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKAS 222
                                     ||||||||||||||::||.||||||||||||||||||||:
 Frog   125 -------------------------VMEFYCQSCETAMCQDCTGGEHAEHPTVPLKDVVEQHKAA 164

Human   223 LQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVN 287
            ||.|||||.|||||||||||.:|||::||.:||.|||::||||||:|||||||||||||||||||
 Frog   165 LQAQLDAVKKRLPEIDSALQCVSEIVNQLASQKTSIVEEIHSTFDDLQKTLNVRKSVLLMELEVN 229

Human   288 YGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPR 352
            |||||||||:|||||::||||||||:.||||||||||||||||||||||:||||||:|||||.|.
 Frog   230 YGLKHKVLQAQLDTLIEGQESIKSCTTFTAQALNHGTETEVLLVKKQMSDKLNELAEQDFPLQPH 294

Human   353 ENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCK 417
            |||||||||||||||||||||||||||||||||||||||||||::||||||||||||||||||||
 Frog   295 ENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQSVIGQPMSVTITTKDKDGELCK 359

Human   418 TGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRS 482
            ||:||::|||.||||||.|||::|||||||||.||:..|||||||||||||||:||||||||::|
 Frog   360 TGSAYISAELFTPDGSVTDGEVVDNKNGTYEFSYTIPTEGDFTLSLRLYDQHIKGSPFKLKVVKS 424

Human   483 ADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRV------------G 535
            ||||||||||||||||||||||||||||||||||||||||||||||||||||            |
 Frog   425 ADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGSRKDEDVRSLTG 489

Human   536 TKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVH 600
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   490 TKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVH 554

Human   601 PSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGK 665
            |||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
 Frog   555 PSGDIIIADYDNKWVSIFSADGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGK 619

Human   666 IVTRFGSRGNGDRQFA----GPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQ 726
            ||||||||||||:|||    ||||||||||||||:|||||||||||||:|||:||||||||||||
 Frog   620 IVTRFGSRGNGDKQFAGTLDGPHFAAVNSNNEIIVTDFHNHSVKVFNQDGEFILKFGSNGEGNGQ 684

Human   727 FNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSG 791
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||
 Frog   685 FNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLSLTSDGHVVVADSG 749

Human   792 NHCFKVYRYLQ 802
            |||||||||||
 Frog   750 NHCFKVYRYLQ 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TRIM2	NP_001362417.1	RAD18	33..>136	CDD:227719	94/102 (92%)
		RING-HC_TRIM2	42..92	CDD:438423	48/49 (98%)
		Bbox_SF	142..214	CDD:469587	37/71 (52%)
		BBC	219..345	CDD:128778	106/125 (85%)
		IG_FLMN	383..479	CDD:214720	81/95 (85%)
		NHL_TRIM2_like	529..802	CDD:271330	266/288 (92%)
		NHL repeat	547..586	CDD:271330	38/38 (100%)
		NHL repeat	594..633	CDD:271330	37/38 (97%)
		NHL repeat	636..673	CDD:271330	36/36 (100%)
		NHL repeat	680..721	CDD:271330	37/44 (84%)
		NHL repeat	727..769	CDD:271330	41/41 (100%)
		NHL repeat	772..798	CDD:271330	24/25 (96%)
trim2	NP_001005680.1	RAD18	2..>109	CDD:227719	98/106 (92%)
		RING-HC_TRIM2	15..65	CDD:438423	48/49 (98%)
		Bbox2_TRIM2_C-VII	115..156	CDD:380882	37/71 (52%)
		CC_brat-like	161..282	CDD:467844	101/120 (84%)
		IG_FLMN	325..421	CDD:214720	81/95 (85%)
		NHL_TRIM2_like	483..760	CDD:271330	260/276 (94%)
		NHL repeat	501..540	CDD:271330	38/38 (100%)
		NHL repeat	548..587	CDD:271330	37/38 (97%)
		NHL repeat	590..627	CDD:271330	36/36 (100%)
		NHL repeat	634..679	CDD:271330	37/44 (84%)
		NHL repeat	685..727	CDD:271330	41/41 (100%)
		NHL repeat	730..756	CDD:271330	24/25 (96%)