DRSC/TRiP Functional Genomics Resources

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Protein Alignment TRIM2 and nhl-1

DIOPT Version :10

Sequence 1:NP_001362417.1 Gene:TRIM2 / 23321 HGNCID:15974 Length:802 Species:Homo sapiens
Sequence 2:NP_499028.1 Gene:nhl-1 / 176295 WormBaseID:WBGene00003597 Length:974 Species:Caenorhabditis elegans


Alignment Length:1033 Identity:226/1033 - (21%)
Similarity:359/1033 - (34%) Gaps:339/1033 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    28 MASEGTNIPSPVVRQIDK--QFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVC 90
            |:...::.|:..|..::|  |.|.|.|||:|||.||:|||.||||..||::........|.||.|
 Worm    19 MSRPPSSRPADFVNPLEKIEQLLTCPICLDRYKQPKLLPCQHTFCYPCLESCADTLHRNLKCPEC 83

Human    91 RQTSILPEKGVAALQNNFFITNLMDV-LQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNRQS 154
            |....:|..||.|.|.|:.:|..::: ||.||.|.||....:                |..|.:.
 Worm    84 RAEHNIPYDGVKAFQPNYTLTGFLEIHLQATPESAAEIEEYI----------------HRYNLER 132

Human   155 FAVVPRLVS-NPWPQVILPPWPSKVLGLQVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQ 218
            ..:...... .|                      |..|:...|:||.:..         .|::::
 Worm   133 CKICDEKADCEP----------------------CAHCDRKACKECRQTH---------MDMLKR 166

Human   219 HKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLME 283
            ..:.|..|:..:..|:.|   |...:|:.:..:|....:...:|...|...|:.|..::...|||
 Worm   167 DMSRLLNQVKRLANRITE---ASDNLSKGVDMMTMNCETTKAEIKEYFHRYQRDLKKKEDNFLME 228

Human   284 LEV-------NYGLKHKVLQ----------SQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLV 331
            ::.       |......||:          |:||..::|:.||:              ::|::.:
 Worm   229 VDTFQATETRNMSNLRDVLEIESSNMSEAVSRLDAAIKGECSIE--------------DSELVRM 279

Human   332 KKQMSEKLNEL------ADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATG 390
            |...:|.|..|      ||:.|      |.:|.|....:..|     |...:||:......|...
 Worm   280 KNTFTEGLEYLRNFQPDADELF------NRKLRFSAGDDAAK-----LPAAITTSGELCVLVPQF 333

Human   391 EG----LRQTIIGQPMSVTITTKD-----------KDGELCKTGNAY------------------ 422
            .|    |.|:.:.:|..:.:.:..           :|.|..:|.:.:                  
 Worm   334 SGRYLPLEQSYLPRPFRLPLESDSYRVKSDERASMRDREADRTSSRHSHRNPEPDESSIRYRRRQ 398

Human   423 -----------------------LTAELS------------------------------------ 428
                                   :||:.|                                    
 Worm   399 QLEDEAWNRLRNSSAAPSLLTTSVTADSSSRTSPWAADRVTRSVEPTKSRPTSLIVPNTETPRTV 463

Human   429 ------------------TPDGSVA------------------DGEILDNKNGTYEFLYTVQKEG 457
                              |.|.|.|                  :.:.|:.|..|....:..:::.
 Worm   464 SPASKPPLPPQSVERVERTEDASPAPLPQLPIRKPPLPRQQSSNDDSLNEKVETIRRAHQQRQDA 528

Human   458 DFTLSLRLYDQHIRGSPFKLK--------VIRSADV----------------------------- 485
            ....|..:..:...|..|.:.        |.|:|.|                             
 Worm   529 SRAASRAVSSEESEGEDFPVSTNRGRIRIVCRAASVNRDDGLMSMIPGTGTIINVPPPQHQLPAS 593

Human   486 SPTTEGVKRRVKSP---------------------------------------GSGHVKQKAVKR 511
            :|.|.|...:|..|                                       .|..|:|...:|
 Worm   594 APITNGTSEQVAIPVTHFTGEEDESDIVVPAWLQRRRQRFQRSRTNPDIQAQFTSARVQQLLAER 658

Human   512 PASMYSTGKRKENPIEDDLIFR----------------------VGTKGRNKGEFTNLQGVAAST 554
            .:.:.|:....|.. |...:.|                      .|.||...||....:|:.|.:
 Worm   659 QSRLDSSTTTDEEK-EKLAVLRQRGRSASREAGEWRARGRPRAVFGRKGAKDGELNWPRGICALS 722

Human   555 NGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFS 619
            .|.:...||:|..|.:|..||:|..:||..|...|||....|:| .....:|::|..|..:|:|.
 Worm   723 GGLVATCDSSNHRVCVFDKDGKFVRQFGGYGAGAGQLDSAAGLA-SSKLRVIVSDRYNHRISVFG 786

Human   620 SDGKFKTKI-----GSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQ 679
            .:|......     |:.|...|.||:||..|.|.|.|.....|.:|..||:.:.:|||.|:...|
 Worm   787 LEGDHLFSFGGHGQGNAKFNNPWGVAVDDLGSIYVADKDNHRVQVFDKNGQFIAKFGSFGHLPGQ 851

Human   680 FAGPHFAAVNS-NNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIV 743
            ...|.|.||:. .:.:.::|..||.:.||:..|..:..||..|...|||..|.|:|:||..|:|:
 Worm   852 LNSPLFIAVSRVTHHVYVSDSSNHRISVFDPHGVHLFSFGEEGFHGGQFKFPRGIAIDSQENLII 916

Human   744 ADWGNSRIQVFDGSGSFLSYINT---SADPLYGPQGLALTSDGHVVVADSGNHCFKVY 798
            ||.||:||||||..|.|:|...|   .|..|.|.:.:.:|:||.:||.|..||..:::
 Worm   917 ADSGNNRIQVFDAQGQFVSSFGTWGGGAGQLKGVEDVCVTADGSIVVTDRENHRIQIF 974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TRIM2NP_001362417.1 RAD18 33..>136 CDD:227719 42/105 (40%)
RING-HC_TRIM2 42..92 CDD:438423 25/51 (49%)
Bbox_SF 142..214 CDD:469587 8/72 (11%)
BBC 219..345 CDD:128778 29/148 (20%)
IG_FLMN 383..479 CDD:214720 21/231 (9%)
NHL_TRIM2_like 529..802 CDD:271330 99/301 (33%)
NHL repeat 547..586 CDD:271330 13/38 (34%)
NHL repeat 594..633 CDD:271330 9/43 (21%)
NHL repeat 636..673 CDD:271330 15/36 (42%)
NHL repeat 680..721 CDD:271330 12/41 (29%)
NHL repeat 727..769 CDD:271330 22/44 (50%)
NHL repeat 772..798 CDD:271330 9/25 (36%)
nhl-1NP_499028.1 RING-HC_NHL-1-like 36..87 CDD:438187 26/50 (52%)
CC_brat-like 160..261 CDD:475168 19/112 (17%)
PLN02217 <388..512 CDD:215130 7/123 (6%)
NHL_TRIM71_like 691..974 CDD:271324 98/283 (35%)
NHL repeat 715..754 CDD:271324 13/38 (34%)
NHL repeat 762..800 CDD:271324 8/38 (21%)
NHL repeat 808..844 CDD:271324 14/35 (40%)
NHL repeat 852..893 CDD:271324 12/40 (30%)
NHL repeat 902..932 CDD:271324 17/29 (59%)
NHL repeat 948..974 CDD:271324 9/25 (36%)

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