Protein Alignment FMR1 and Fmr1

DIOPT Version :10

• Sequence 1: NP_002015.1
• Gene: FMR1 / 2332
• HGNCID: 3775
• Length: 632
• Species: Homo sapiens
• Sequence 2: NP_001418541.1
• Gene: Fmr1 / 24948
• RGDID: 2623
• Length: 614
• Species: Rattus norvegicus
• Alignment Length: 632
• Identity: 593/632 - (93%)
• Similarity: 603/632 - (95%)
• Gaps: 18/632 - (2%)

Human     1 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPPPVGYNKDINESDEV 65
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||
  Rat     1 MEELVVEVRGSNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPPPVGYNKDINESDEV 65

Human    66 EVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIK 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 EVYSRANEKEPCCWWLAKVRMIKGEFYVIEYAACDATYNEIVTIERLRSVNPNKPATKDTFHKIK 130

Human   131 LDVPEDLRQMCAKEAAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTK 195
            |:||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 LEVPEDLRQMCAKESAHKDFKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTK 195

Human   196 LSLIMRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTC 260
            ||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 LSLILRNEEASKQLESSRQLASRFHEQFIVREDLMGLAIGTHGANIQQARKVPGVTAIDLDEDTC 260

Human   261 TFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKN 325
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
  Rat   261 TFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIGKNGKLIQEIVDKSGVVRVRIEAENEKS 325

Human   326 VPQEEEIMPPNSLPSNNSRVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRVLVASSVVAGESQKP 390
            ||||||.:||:||||||||||.|:.|||||||.||| ||||||||||||||||.||:|||..|||
  Rat   326 VPQEEENLPPSSLPSNNSRVGSNSSEEKKHLDTKEN-THFSQPNSTKVQRVLVVSSIVAGGPQKP 389

Human   391 ELKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRT 455
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   390 EPKAWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQIGASSRPPPNRT 454

Human   456 DKEKSYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEE 520
            ||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   455 DKEKGYVTDDGQGMGRGSRPYRNRGHGRRGPGYTSGTNSEASNASETESDHRDELSDWSLAPTEE 519

Human   521 ERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPREAKGRTTDGSLQIRVDCN 585
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
  Rat   520 ERESFLRRGDGRRRGGGGRGQGGRGRGGGFKGNDDHSRTDNRPRNPRETKGRTTDGS-------- 576

Human   586 NERSVHTKTLQNTSSEGSRLRTGKDRNQKKEKPDSVDGQQPLVNGVP 632
                     ||:||||||||||||||||||||||||||.||||||||
  Rat   577 ---------LQSTSSEGSRLRTGKDRNQKKEKPDSVDGLQPLVNGVP 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FMR1	NP_002015.1	Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:P35922	1..184		179/182 (98%)
		Tudor_Agenet_FMR1_rpt1	1..55	CDD:410542	52/53 (98%)
		Tudor_Agenet_FMR1_rpt2	58..120	CDD:410545	61/61 (100%)
		KH_I_FMR1_rpt1	123..199	CDD:411934	73/75 (97%)
		Necessary for interaction with CYFIP1, CYFIP2, FXR1 and FXR2. /evidence=ECO:0000250|UniProtKB:P35922, ECO:0000269|PubMed:14532325, ECO:0000269|PubMed:8668200	172..211		37/38 (97%)
		KH_I_FMR1_rpt2	218..280	CDD:411937	61/61 (100%)
		KH-I	281..424	CDD:469614	128/142 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..349		18/23 (78%)
		Required for nuclear export. /evidence=ECO:0000269|PubMed:18936162, ECO:0000269|PubMed:8789445	397..491		92/93 (99%)
		Interaction with RANBP9. /evidence=ECO:0000269|PubMed:15381419	419..632		191/212 (90%)
		FXMRP1_C_core	420..525	CDD:463501	103/104 (99%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35922	424..443		18/18 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:30765518, ECO:0000269|PubMed:31439799	443..632		167/188 (89%)
		Nucleolar localization signal 1. /evidence=ECO:0000269|PubMed:24658146	527..534		6/6 (100%)
		RNA-binding RGG-box	534..548		13/13 (100%)
		FXMR_C2	550..632	CDD:465020	61/81 (75%)
		Nucleolar localization signal 2. /evidence=ECO:0000269|PubMed:24658146	613..617		3/3 (100%)
Fmr1	NP_001418541.1	Tudor_Agenet_FMR1_rpt1	1..55	CDD:410542	52/53 (98%)
		Tudor_Agenet_FMR1_rpt2	58..120	CDD:410545	61/61 (100%)
		KH_I_FMR1_rpt1	123..199	CDD:411934	73/75 (97%)
		KH_I_FMR1_rpt2	218..280	CDD:411937	61/61 (100%)
		KH-I	281..423	CDD:469614	128/142 (90%)
		FXMRP1_C_core	419..524	CDD:463501	103/104 (99%)
		FXMR_C2	549..614	CDD:465020	61/81 (75%)