DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TUT4 and Tailor

DIOPT Version :9

Sequence 1:	XP_005270733.1	Gene:	TUT4 / 23318	HGNCID:	28981	Length:	1652	Species:	Homo sapiens
Sequence 2:	NP_001262327.1	Gene:	Tailor / 40847	FlyBaseID:	FBgn0037470	Length:	563	Species:	Drosophila melanogaster

Alignment Length:	329	Identity:	84/329 - (25%)
Similarity:	140/329 - (42%)	Gaps:	83/329 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   986 EYD----------------EKARLCLFGSSKNGFGFRDSDLDICM----------TLEGHENAEK 1024
            |||                :..|:..|||...|.|.|.||||:.:          |.| |..:..
  Fly   239 EYDVIEQDLCKLLSPGFPKQPLRVYKFGSRITGIGNRSSDLDLFVDIGKSGNTFHTFE-HRASNA 302

Human  1025 LNCKEIIENLAKILKRHPGLRNILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYA 1089
            ...|  :..:.|........|.|..|..|:|||:|..|..:|:|.||.| |::...||.:|....
  Fly   303 TVAK--LRAMRKFFCDSEDWRLINFIEQARVPIIKTCHLPTGIECDICL-NSMGFCNTNLLKYIF 364

Human  1090 AIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYAYILMVLYFLQ-QRKPPVIPVLQEIFDGKQIP 1153
            ...|..||:...:|.:.:||.:.:    .:|:|:..|||:|||| |...|.|.:|| |.|...
  Fly   365 ESQPLTQYMCIYVKNWLERCKLTE----QISTYSITLMVIYFLQLQALLPPIAMLQ-IEDAAN-- 422

Human  1154 QRMVDG-WNAFFFDKT------EELKKRLPSLGKNTESLGELWLGLLR---FYTEEFDFKEYVI- 1207
            |.::.| |...|..|:      ::||..:|.:           .|.||   .|..:||::.:::
  Fly   423 QAVLVGPWVVNFAQKSFSELGLQQLKATVPVI-----------KGFLRNFFAYFAKFDYEHFLVC 476

Human  1208 ------SIRQKKLLTTFEKQWTS-------------KCIAIEDPFDLNHNLGAGVSRKMTNFIMK 1253
                  ::...|:......::::             |.:.::||..||||    |::.:|.:.::
  Fly   477 PYIGQANVEIAKIERMLHARYSAYVSDNPECSIQLKKPMVVQDPIQLNHN----VTKAVTKYGLQ 537

Human  1254 AFIN 1257
            .|::
  Fly   538 TFVD 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TUT4	XP_005270733.1	NT_PAP_TUTase	375..487	CDD:143392
		PAP_assoc	628..677	CDD:281779
		NT_PAP_TUTase	971..1089	CDD:143392	37/128 (29%)
		PAP_assoc	1184..1237	CDD:281779	11/75 (15%)
		PTZ00368	<1280..1375	CDD:173561
		CytochromB561_N	1375..>1516	CDD:286826
		DUF1421	<1383..1650	CDD:284607
		FAM75	1423..>1484	CDD:291323
Tailor	NP_001262327.1	DUF1439	<70..126	CDD:297551
Tailor	NP_001262327.1	NT_PAP_TUTase	245..364	CDD:143392	34/122 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810