Protein Alignment CUX2 and COY1

DIOPT Version :10

• Sequence 1: NP_056082.2
• Gene: CUX2 / 23316
• HGNCID: 19347
• Length: 1486
• Species: Homo sapiens
• Sequence 2: NP_012742.1
• Gene: COY1 / 853675
• SGDID: S000001662
• Length: 679
• Species: Saccharomyces cerevisiae
• Alignment Length: 465
• Identity: 114/465 - (24%)
• Similarity: 196/465 - (42%)
• Gaps: 95/465 - (20%)

Human    12 WKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVV 76
            |.:.||..||:||::...|:..::..|.:|.|.|....::|||..|||....|..::|.:|.|:.
Yeast    13 WAKADLTNLQRELDADVIEIKDKETLSLNSRKSLATETKKFKKLEPEEKLNNVNKIIKQYQREID 77

Human    77 ALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAA----RSLDDRLQPPSFDPSGQPRRDLHTSWKR 137
            .|::||:.:|.....||::|.|||||.|:.:::    ..:||.                    |.
Yeast    78 NLTQRSKFSEKVLFDVYEKLSEAPDPQPLLQSSLEKLGKIDDS--------------------KE 122

Human   138 NPELLSPKEQREGTSPAGPTLTEGSRLPGIPGKALLTETLLQRNEA----------EKQKGLQEV 192
            ..|.:|..|.:........||.  |||..:...:  .:||.:|..|          ||.:..:|.
Yeast   123 LKEKISYLEDKLAKYADYETLK--SRLLDLEQSS--AKTLAKRLTAKTQEINSTWEEKGRNWKER 183

Human   193 QITLAARLGEAEEKIKVLHSALKATQAELLELRRKYDE---------EAASKADEVGLIMTNLEK 248
            :..|..:|...:|:.|    ||:|..::.:::....:|         |.:::..|..|:...||.
Yeast   184 EADLLKQLTNVQEQNK----ALEAKISKNIDIEGNGNEDGDQENNQKEVSTRIAEYNLVTQELET 244

Human   249 ANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRL 313
            ...|....::..|.|...||...|            ..:|           |..|.:|:.::.:|
Yeast   245 TQARIYQLEKRNEELSGALAKATS------------EAEK-----------ETELHAKELKLNQL 286

Human   314 LKDVQHLQSSLQELEEASANQIADLERQL---TAKSEA----IEKLEEKLQAQSDYEEIKTELSI 371
            ..:...|.:|.::..:::::.|.:|:.||   .|:||:    :|.:..||...|||.:||.|||.
Yeast   287 ESENALLSASYEQERKSTSHAINELKEQLNSVVAESESYKSELETVRRKLNNYSDYNKIKEELSA 351

Human   372 LKAMKLASSTCSLPQGMAKP-------EDSLLIAKEAFFPTQKFLLEKPSLLASPEEDPSE---- 425
            ||.::...:.......:...       |.|||.|.:..   |..|.|..|...:.||:.:|
Yeast   352 LKKIEFGVNEDDSDNDIRSEDKNDNTFESSLLSANKKL---QATLAEYRSKSTAQEEERNELKKS 413

Human   426 DDSIKDSLGT 435
            .|.:|..:.|
Yeast   414 VDQLKQQIAT 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUX2	NP_056082.2	PRK03918	<17..>269	CDD:235175	68/274 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..167		10/52 (19%)
		Smc	<179..>379	CDD:440809	51/225 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..481		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..549
		CUT	553..625	CDD:460543
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..690
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..758
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..858
		CUT	892..965	CDD:460543
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1032
		CUT	1043..1119	CDD:460543
		Homeodomain	1169..1225	CDD:459649
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1231..1453
COY1	NP_012742.1	SMC_N	<16..335	CDD:481474	86/369 (23%)
		SMC_prok_B	225..>436	CDD:274008	53/225 (24%)
		CASP_C	409..638	CDD:462392	4/15 (27%)