DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CUX2 and cux2b

DIOPT Version :10

Sequence 1:NP_056082.2 Gene:CUX2 / 23316 HGNCID:19347 Length:1486 Species:Homo sapiens
Sequence 2:XP_073766143.1 Gene:cux2b / 565530 ZFINID:ZDB-GENE-081104-176 Length:1460 Species:Danio rerio


Alignment Length:1541 Identity:885/1541 - (57%)
Similarity:1040/1541 - (67%) Gaps:180/1541 - (11%)


- Green bases have known domain annotations that are detailed below.


Human    21 QKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVALSKRSQEA 85
            ::||||||::|:.||||||.|||||:||.|||||||||::.|||:||||||||:|||||:||:||
Zfish    25 ERELNSVAAQLAGRQEESEDSHKHLVELSREFKKNVPEDVLEMVSPVLKSFQAQVVALSQRSKEA 89

Human    86 EAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPR-RDLHTSWKRNPELLSPKEQRE 149
            |:|||::||||||||||.|:.||.:.....||..:  |.|... .::...|:|..|.|   ::.|
Zfish    90 ESAFLAIYKQLIEAPDPAPLLEATQQRLAELQRSA--PEGDALITEVSDRWRRRLECL---DKAE 149

Human   150 GTSPAGPTLTE----GSRLPGI--PGKALLTETLLQ-----RNEAEKQKGLQEVQ--ITLAARLG 201
            .|...||...|    .::.|.:  |..   |:|:..     :|..|..:|.:|.|  ..|..||.
Zfish   150 HTEEEGPVTVETGEVSTQKPHMMTPNS---TQTVQDGDAPLQNHQEPLQGEEEDQSDAPLPVRLD 211

Human   202 EAEEKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQ 266
            :||.:||.|.|:|...:.||.|||.|||:|.|.|.:|:..:|.|||||||||:|||||||.||||
Zfish   212 QAELRIKALQSSLSTARTELQELRCKYDQEKAEKLEEMCALMANLEKANQRADAAQREVEKLREQ 276

Human   267 LASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEAS 331
            |:...|:.:     ..|||.::.........||||.|.||||||||||::||.||.:|||::::|
Zfish   277 LSGTQSTSK-----GTGPSEERPKEERERDERLEALLFSKDREILRLLENVQRLQFTLQEVQDSS 336

Human   332 ANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSLPQGMAKPEDSLL 396
            |||||:|||||..||||||.||.|||:|.|||||||||||||||||||:..|..|...|..::||
Zfish   337 ANQIAELERQLAYKSEAIETLETKLQSQIDYEEIKTELSILKAMKLASANGSSSQESGKTAEALL 401

Human   397 IAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPG-----PEDPLS 456
            :.||||.|:.|||::|..:|.:.::..||..:  |......||.||....|..|     |..|.|
Zfish   402 LDKEAFLPSHKFLVDKVKVLHNSDDGHSEKSN--DVSRPAGSYSSPPGTLPIDGRTSSSPAPPTS 464

Human   457 PSPGQPLLGPSLGPDGTRTFSLSPFPSLASGERL--------MMPPAAFKGEAGGLLVFPPAFYG 513
            .:....|         .|.||:|||    |||:|        ::.| .||.:...::.||.|.|.
Zfish   465 DTSTHTL---------PRPFSVSPF----SGEKLQDQLLQKQLLSP-LFKKDGSSIMAFPTALYA 515

Human   514 AKPPTAPAT-PAPGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFG 577
            ||.....|. .|..|..:....|:|....|::| |.:::||||||||||||||||||||||||||
Zfish   516 AKAALLSANHSASIPITMETGMPSDQSESGSSG-GGDDDQLDTAEIAFQVKEQLLKHNIGQRVFG 579

Human   578 HYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGSITPRIRT 642
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
Zfish   580 HYVLGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNILALRTIQVRQRGSITPRIRT 644

Human   643 PETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQARREMQAQ 707
            ||||||||||||||||||||:||: |:.|:|:...|..:.|...|:|::||||||||||||||||
Zfish   645 PETGSDDAIKSILEQAKKEIQSQR-GDCKSSLGCPSGRSSTGAGSSSDEAIKSILEQARREMQAQ 708

Human   708 QQALLEMEVAPRGRSVPPSPPERPSL---ATASQNGAPALVKQEEG----------SGGPAQAPL 759
            |||||||||.  |||   |..||.|:   ..:..:..|..:|||||          :|.| |.||
Zfish   709 QQALLEMEVC--GRS---SASERLSIHDPPKSQASSTPPFIKQEEGISVPQSLSNPTGSP-QTPL 767

Human   760 PVLSPAAFVQSIIRKVKSEIGDAG-YFDHHWASDR-GLLSRPYASVSPSLSSSSSSGYSGQPNGR 822
            .|||||||||:||||||||||:|| |||.||:.:| ..:..|:.|||||||||||:...     |
Zfish   768 SVLSPAAFVQNIIRKVKSEIGEAGTYFDQHWSVERSAAVMGPFTSVSPSLSSSSSTSMP-----R 827

Human   823 AWPRGDEAPVPPEDEAAAGAEDEP--PRTGELKAE---GATAEA---GARLPYYPAYVPRTLKPT 879
            .|||.:....|...|..:..||||  .|..|:|.|   ..::||   |.|:.:||.|:|||||||
Zfish   828 PWPRIENGDCPANGEDTSAPEDEPMLSRQVEIKVEPDASVSSEASCGGGRVSFYPTYIPRTLKPT 892

Human   880 VPPLTPEQYELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKL 944
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   893 VPPLTPEQYEMYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKL 957

Human   945 TQKGREPFIRMQLWLSDQLGQAVGQQPG---ASQASPTEPRSSPSPPPSPTEPEKSS-QEPLSLS 1005
            |||||||||||||||.||||..:.|.|.   :.:.||...|||||||.||.:.:.|: .||:||:
Zfish   958 TQKGREPFIRMQLWLLDQLGHGLNQLPNHNHSQEKSPVTSRSSPSPPASPADAQSSTVLEPVSLA 1022

Human  1006 LESSKENQQPE--------GRSSSSLSGKMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTD 1062
            ||||||||||:        |..||.:..:.   :..|.||||:||||||||||:|||||||||||
Zfish  1023 LESSKENQQPQPPQPLEPHGVKSSVMIPQQ---THTPLGIQELVAMSPELDTYAITKRVKEVLTD 1084

Human  1063 NNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEK 1127
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||:||:||
Zfish  1085 NNLGQRLFGESILGLTQGSVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVDKLRDVKKMEK 1149

Human  1128 KAYLKRRYGLISTGSDSESPATRSECPSPCLQPQDL-SLLQIKKPRVVLAPEEKEALRKAYQLEP 1191
            ||||||||||:|.||||:||...|:|.||.|...|| ...|.||||||||.||||||||||..||
Zfish  1150 KAYLKRRYGLLSPGSDSDSPGAHSDCISPGLSALDLCPFSQAKKPRVVLAAEEKEALRKAYLQEP 1214

Human  1192 YPSQQTIELLSFQLNLKTNTVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDP 1256
            ||||.|||:|:.|||||||||||||||||||||||:|:||.||. |.|..         |::..|
Zfish  1215 YPSQHTIEMLAAQLNLKTNTVINWFHNYRSRMRREVLMEGLQDN-DTDAE---------HNNYSP 1269

Human  1257 -TPQSPDSETEDQK--PTVKELELQEGPEENSTPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDS 1318
             ...||.|:.||:|  |:|:...:...|.            :..||||..|.:.||....|    
Zfish  1270 LASHSPVSDREDRKQPPSVRNRSVSTIPH------------RFAIKQETTEPEDEELRLRQ---- 1318

Human  1319 GELDK--GQGPPKEEHPDPPGNDGLPKVAPGPLLPGGSTPDCPSLHPQQESEA---GERLH---P 1375
               ||  ..|..|.|.|....|          |||.|         ||:.|.|   ||.|.   .
Zfish  1319 ---DKCFSIGAFKSEEPGRSLN----------LLPDG---------PQRNSSASHEGEELEKSPE 1361

Human  1376 DPLSFKSASESSRCSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTAD 1440
            ||:|||::||.||.||||||||||||||||||||||||||||||||||||..|..:.||.     
Zfish  1362 DPVSFKASSEPSRSSLEVSLNSPSAASSPGLMMSVSPVPSSSAPISPSPPNPPALEPPSL----- 1421

Human  1441 MAGALHPSAKVNPNLQRRHEKMANLNNIIYRVERAANREEALEWEF 1486
                   :||:|.|.|||:||||||||||:|:||||||||.|||||
Zfish  1422 -------NAKLNKNTQRRNEKMANLNNIIHRLERAANREETLEWEF 1460

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CUX2NP_056082.2 PRK03918 <17..>269 CDD:235175 132/261 (51%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..167 14/57 (25%)
Smc <179..>379 CDD:440809 115/206 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..481 18/70 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..549 8/32 (25%)
CUT 553..625 CDD:460543 70/71 (99%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..690 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..758 17/54 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..858 25/62 (40%)
CUT 892..965 CDD:460543 71/72 (99%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1032 32/79 (41%)
CUT 1043..1119 CDD:460543 73/75 (97%)
Homeodomain 1169..1225 CDD:459649 48/55 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1231..1453 92/232 (40%)
cux2bXP_073766143.1 None

Return to query results.
Submit another query.