Protein Alignment CUX2 and Cux2

DIOPT Version :10

• Sequence 1: NP_056082.2
• Gene: CUX2 / 23316
• HGNCID: 19347
• Length: 1486
• Species: Homo sapiens
• Sequence 2: XP_038945174.1
• Gene: Cux2 / 288665
• RGDID: 1305967
• Length: 1522
• Species: Rattus norvegicus
• Alignment Length: 1513
• Identity: 1238/1513 - (81%)
• Similarity: 1295/1513 - (85%)
• Gaps: 58/1513 - (3%)

Human    13 KRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVVA 77
            :|.|||||||||||||||||..|||||||.|.||||||||||||||.||.|||||||||||||||
  Rat    29 RRLDLRRLQKELNSVASELSVPQEESEHSPKRLIELRREFKKNVPEGIRAMVAPVLKSFQAEVVA 93

Human    78 LSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPELL 142
            |||||||||||||||||||||||||||..|.||:||||||.|||.||||..||:|.||||.||..
  Rat    94 LSKRSQEAEAAFLSVYKQLIEAPDPVPSVEVARTLDDRLQRPSFHPSGQRLRDVHISWKRCPEPP 158

Human   143 SPKEQREGTSPAGPTLTEGSRLPGIPGKALLTETLLQRNEAEKQKGLQEVQITLAARLGEAEEKI 207
            |.:||.|||.|.|.|...|:.||| |...|:|:||||::|||:|||||||.:|||||||||||||
  Rat   159 SAREQNEGTCPTGHTPANGNHLPG-PEDTLVTDTLLQKDEAERQKGLQEVHVTLAARLGEAEEKI 222

Human   208 KVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNS 272
            |||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   223 KVLHSALKATQTELLELRRKYDEEAASKADEVGLIMTNLEKANQRAEAAQREVESLREQLASVNS 287

Human   273 SIRLACCSPQGPSGDKVNFTLCSGPRLEAALASKDREILRLLKDVQHLQSSLQELEEASANQIAD 337
            ||||||||||||.|:||:|.||||||||||||||||||||||||.|.|:.|||||||.|||||||
  Rat   288 SIRLACCSPQGPGGEKVSFALCSGPRLEAALASKDREILRLLKDAQQLRHSLQELEEVSANQIAD 352

Human   338 LERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAMKLASSTCSL-------PQGMAKPEDSL 395
            |||||.|||||||||:|||:||:||||||||||||:|||||||||||       ||.:.||:|.|
  Rat   353 LERQLAAKSEAIEKLQEKLEAQADYEEIKTELSILRAMKLASSTCSLPQPCFPSPQALGKPDDPL 417

Human   396 LIAKEAFFPTQKFLLEKPSLLASPEEDPSEDDSIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPG 460
            |:||:|||||||.|||||:||||||||||||||||.|||.|.||  |.||||||||||||||||.
  Rat   418 LMAKDAFFPTQKLLLEKPALLASPEEDPSEDDSIKGSLGMEPSY--PPQLPPPPGPEDPLSPSPT 480

Human   461 QPLLGPSLGPDGTRTFSLSPFPSLASGERL---------MMPPAAFKGEAGGLLVFPPAFY-GAK 515
            ||||||||||||.||||||||||||.||||         ||.|.|||||.|.||.|||||| |||
  Rat   481 QPLLGPSLGPDGPRTFSLSPFPSLAPGERLAGDPLLSKHMMAPVAFKGETGNLLAFPPAFYGGAK 545

Human   516 PPTAPATPAPGPEPLGGPEPADGGGGGAAGPGAEEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYV 580
            ||||||.|.|||||.|.|||.||     |||  ||||||||||||||||||||||||||||||||
  Rat   546 PPTAPAAPVPGPEPSGAPEPVDG-----AGP--EEEQLDTAEIAFQVKEQLLKHNIGQRVFGHYV 603

Human   581 LGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQR-----------G 634
            |||||||||||||||||||||||||||||||||||||||||||||||||||||           |
  Rat   604 LGLSQGSVSEILARPKPWRKLTVKGKEPFIKMKQFLSDEQNVLALRTIQVRQRGPTAATFVPPPG 668

Human   635 SITPRIRTPETGSDDAIKSILEQAKKEIESQKGGEPKTSVAPLSIANGTTPASTSEDAIKSILEQ 699
            |||||||||||||||||||||||||||||||||||.|.|.|.:||.|||..:||||||||:||||
  Rat   669 SITPRIRTPETGSDDAIKSILEQAKKEIESQKGGESKNSPASVSIPNGTASSSTSEDAIKNILEQ 733

Human   700 ARREMQAQQQALLEMEVAPRGRSVPPSPPERPSLATASQNGAPALVKQEEG-----SGGPAQAPL 759
            ||||||||||||||||..|||||||||||||||.||.|||||.|.||||:|     |.|.|||||
  Rat   734 ARREMQAQQQALLEMESGPRGRSVPPSPPERPSPATMSQNGALACVKQEDGGCSSSSSGSAQAPL 798

Human   760 PVLSPAAFVQSIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSSSGYSGQPNGRAW 824
            .|||||||||.||||||||||||||||||||||||||||||||||||||||||  ||||||||||
  Rat   799 AVLSPAAFVQRIIRKVKSEIGDAGYFDHHWASDRGLLSRPYASVSPSLSSSSS--YSGQPNGRAW 861

Human   825 PRGDEAPVPPEDEAAAG-AEDEPPRTGELKAEGATAE-AGARLPYYPAYVPRTLKPTVPPLTPEQ 887
            ||||||.:.||||||.| .|||.||.||||||...:| .|.||||||||||||||||||||||||
  Rat   862 PRGDEATIAPEDEAATGMGEDEAPRVGELKAEAGVSEVGGGRLPYYPAYVPRTLKPTVPPLTPEQ 926

Human   888 YELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPF 952
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   927 YELYMYREVDTLELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPF 991

Human   953 IRMQLWLSDQL--GQAVGQQPGASQASPTEPRSSPSPPPSPTEPEKSSQEPLSLSLESSKENQQP 1015
            |||||||||||  |||..|||.|||||||||.||||||||||||||:|||||.||||||||||||
  Rat   992 IRMQLWLSDQLGQGQAPNQQPSASQASPTEPTSSPSPPPSPTEPEKTSQEPLGLSLESSKENQQP 1056

Human  1016 EGRSSSSLSGKMYSGSQAPGGIQEIVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQG 1080
            |||:||:|.||..|.||..|||||:||||||||||||||||||||||||||||||||||||||||
  Rat  1057 EGRASSTLGGKPLSSSQTTGGIQEMVAMSPELDTYSITKRVKEVLTDNNLGQRLFGESILGLTQG 1121

Human  1081 SVSDLLSRPKPWHKLSLKGREPFVRMQLWLNDPHNVEKLRDMKKLEKKAYLKRRYGLISTGSDSE 1145
            ||||||||||||||||||||||||||:|||:||||||||||:|||||||||||||||||||||||
  Rat  1122 SVSDLLSRPKPWHKLSLKGREPFVRMRLWLSDPHNVEKLRDVKKLEKKAYLKRRYGLISTGSDSE 1186

Human  1146 SPATRSECPSPCLQPQDLSLLQIKKPRVVLAPEEKEALRKAYQLEPYPSQQTIELLSFQLNLKTN 1210
            |||..|||||||||||:|||:|.|||||||||.||||||||||||||||||||||||||||||||
  Rat  1187 SPAAHSECPSPCLQPQELSLMQAKKPRVVLAPAEKEALRKAYQLEPYPSQQTIELLSFQLNLKTN 1251

Human  1211 TVINWFHNYRSRMRREMLVEGTQDEPDLDPSGGPGILPPGHSHPDPTPQSPDSETEDQKPTVKEL 1275
            ||:|||||||||||||||||||||:||.|||||..:||.||:|.||||||||||.|||||.:|.|
  Rat  1252 TVVNWFHNYRSRMRREMLVEGTQDDPDFDPSGGSSVLPSGHTHTDPTPQSPDSEIEDQKPPMKSL 1316

Human  1276 ELQ--EGPEENSTPLTTQDKAQVRIKQEQMEEDAEEEAGSQPQDSGELDKGQGPPKEEHPDPPGN 1338
            |||  |.|...:.|    |:|.|:|||   ||..|.:..|||||.|:.|:|||.||||...|.||
  Rat  1317 ELQEPESPVHQAAP----DRAVVKIKQ---EEGLEVDGDSQPQDIGDPDRGQGGPKEEDTHPLGN 1374

Human  1339 DGLPKVAPGPLLPGGSTPDCPSLHPQQESEAGERLHPDPLSFKSASESSRCSLEVSLNSPSAASS 1403
            :.|.::.|||.|||...|||.|||..|..|.||::|.:||||||.||||.||||...|||||.||
  Rat  1375 NELSELVPGPFLPGTPNPDCSSLHTPQAKETGEQVHSEPLSFKSTSESSCCSLEGPPNSPSAISS 1439

Human  1404 PGLMMSVSPVPSSSAPISPSPPGAPPAKVPSASPTADMAGALHPSAKVNPNLQRRHEKMANLNNI 1468
            |.||..|||.||||||||||.||..||||||.|||||.|.|||||.|||||||||||||||||:|
  Rat  1440 PDLMTCVSPAPSSSAPISPSLPGTLPAKVPSTSPTADPAAALHPSTKVNPNLQRRHEKMANLNSI 1504

Human  1469 IYRVERAANREEALEWEF 1486
            |||:||||||||||||||
  Rat  1505 IYRLERAANREEALEWEF 1522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CUX2	NP_056082.2	PRK03918	<17..>269	CDD:235175	209/251 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..167		32/52 (62%)
		Smc	<179..>379	CDD:440809	179/199 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..481		57/65 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..549		20/31 (65%)
		CUT	553..625	CDD:460543	71/71 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..690		19/28 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	716..758		32/46 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	800..858		47/58 (81%)
		CUT	892..965	CDD:460543	72/74 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1032		55/67 (82%)
		CUT	1043..1119	CDD:460543	73/75 (97%)
		Homeodomain	1169..1225	CDD:459649	53/55 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1231..1453		141/223 (63%)
Cux2	XP_038945174.1	Smc	<194..>394	CDD:440809	179/199 (90%)
		CUT	572..648	CDD:460543	75/75 (100%)
		CUT	931..1004	CDD:460543	72/72 (100%)
		CUT	1084..1160	CDD:460543	73/75 (97%)
		Homeodomain	1210..1266	CDD:459649	53/55 (96%)