DRSC/TRiP Functional Genomics Resources

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Protein Alignment CUX2 and coy1

DIOPT Version :10

Sequence 1:NP_056082.2 Gene:CUX2 / 23316 HGNCID:19347 Length:1486 Species:Homo sapiens
Sequence 2:NP_587840.1 Gene:coy1 / 2539476 PomBaseID:SPCC364.04C Length:633 Species:Schizosaccharomyces pombe


Alignment Length:529 Identity:135/529 - (25%)
Similarity:216/529 - (40%) Gaps:151/529 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    12 WKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIR--EMVAPVLKSFQAE 74
            ||......||:|.:..|:|:...|:.|....|.|....:||:|. |:|::  ||.. :||.:|:.
pombe    16 WKNSRFEELQREADEAAAEIEKMQKTSLDERKELSSKTKEFRKQ-PDEVKLGEMKG-LLKLYQSG 78

Human    75 VVALSKRSQEAEAAFLSVYKQLIEAPDPVP-VFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRN 138
            :.:|:||::.|||.|..||:.|.|.|||.| :.|||.:|..:                    |:.
pombe    79 IDSLTKRAKSAEATFFRVYETLGEVPDPYPLLIEAANNLKTQ--------------------KQI 123

Human   139 PELLSPKEQREGTSPAGPTLTEGSRLPGIPGKALL---TETLLQRNEAEKQKGLQEVQITLAARL 200
            .:|...||:.||:               :.||..|   .|.|  |.|.:|.|.|.|.:....|.:
pombe   124 EDLKKEKEEMEGS---------------LQGKEKLEREVENL--RKELDKYKDLVETEAEKRAAI 171

Human   201 GEAE-EK-------------------IKVLHSALKATQAELL--ELRRKYDEEAA----SKADEV 239
            .:.| ||                   |:.|.|.::..||..|  :|:...:|.|.    :|:.||
pombe   172 TKEECEKSWLEQQKLYKDMEQENASTIQKLTSKIRELQASQLDHDLQASQNESAGLDVNAKSAEV 236

Human   240 GLIMTNLEKANQRAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSGPRLEAALA 304
            ..|::.|:.||:.....|.|:..|::......|          |.|.|.              |:
pombe   237 NAILSELDDANKIIVELQAEIAVLKQNTKEQKS----------GSSQDD--------------LS 277

Human   305 SKDREILRLLKDV-QHLQSSLQELEEASANQ-------IADLERQLTAKSEAIEKLEEKLQAQ-- 359
            ::.::.|..:..: :.|.:.|:.::|||..:       |..||.::   .||.:..||.|...  
pombe   278 NQQKQQLDFMDSLNKKLSTELESIKEASRKEMETHCATIQTLENEV---KEARKVKEESLTLANK 339

Human   360 -SDYEEIKTELSILKAMKLAS-----STCSLPQGMAKPEDSL-------------------LIAK 399
             |||:|||.|||:||.::.:.     ...||...:.|.|..|                   ..:|
pombe   340 FSDYDEIKRELSVLKQIEFSGEHATHENTSLESQLLKREKQLSEELAKLRSTNAQLTDRITQESK 404

Human   400 EAFFPTQKFLLEKPSLLASPEEDPSEDD---SIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPGQ 461
            :|.|..|| ..|:..::...|:|.::.|   |:..|..|.:...:..||            ||..
pombe   405 KASFLEQK-ASEQEEVIRKLEKDLADVDVEGSVYLSNTTYRREGTSGQL------------SPTS 456

Human   462 PLLG--PSL 468
            .::|  |||
pombe   457 SIMGGNPSL 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CUX2NP_056082.2 PRK03918 <17..>269 CDD:235175 78/283 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..167 6/52 (12%)
Smc <179..>379 CDD:440809 59/236 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..481 14/59 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..549
CUT 553..625 CDD:460543
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..758
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..858
CUT 892..965 CDD:460543
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1032
CUT 1043..1119 CDD:460543
Homeodomain 1169..1225 CDD:459649
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1231..1453
coy1NP_587840.1 SMC_prok_B <117..428 CDD:274008 84/375 (22%)
CASP_C 404..621 CDD:462392 20/75 (27%)
Blue background indicates that the domain is not in the aligned region.

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