DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CUX2 and cone-1

DIOPT Version :10

Sequence 1:NP_056082.2 Gene:CUX2 / 23316 HGNCID:19347 Length:1486 Species:Homo sapiens
Sequence 2:NP_497577.2 Gene:cone-1 / 175372 WormBaseID:WBGene00306126 Length:621 Species:Caenorhabditis elegans


Alignment Length:540 Identity:113/540 - (20%)
Similarity:215/540 - (39%) Gaps:108/540 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    12 WKRFDLRRLQKELNSVASELSARQEESEHSHKHLIELRREFKKNVPEEIREMVAPVLKSFQAEVV 76
            |:..|..|:|..:.:..:.|..||::||.....|:|....::....::.|::..|::|:||:|..
 Worm     8 WESVDWDRIQTRVEAEVTALGQRQDDSEIRKTRLVEESNAYRGRTNKDSRKVAIPLIKAFQSEFD 72

Human    77 ALSKRSQEAEAAFLSVYKQLIEAPDPVPVFEAARSLDDRLQPPSFDPSGQPRRDLHTSWKRNPEL 141
            .|..||..||.|.:.:.|.::..|||..:.:.|.                       :||.:.|.
 Worm    73 GLLARSTAAENALIDICKSIVSLPDPKSLLKGAE-----------------------AWKNDAEK 114

Human   142 LSPK-EQREGTSPAGPTLTEGSRLPGIPGKALLTETLLQR----------------NEAEKQKGL 189
            .... |:||...  ...:...:.|..:.||.:....|..:                ||.|| |..
 Worm   115 TQKAVEEREELK--RQLIKVNNELEDLRGKDVKVRKLKDKLAKLESEQDIFIENAVNEVEK-KAE 176

Human   190 QEVQITLAARLGEAE---EKIKVLHSALKATQAELLELRRKYDEEAASKADEVGLIMTNLEKANQ 251
            ||:...|...:.|.|   |:.::|...:.:.:::..:::||.:....:...:.||....|..|.:
 Worm   177 QELNDRLTELIAEKEKMKEQNEILEKNMDSLESKNKDIQRKLEIAKQTVEQKDGLENEQLSIAMK 241

Human   252 RAEAAQREVESLREQLASVNSSIRLACCSPQGPSGDKVNFTLCSG-----PRLEAALASKDREIL 311
            ....|:.::..|.|:::.:.:            ..:|||.:..:|     ..|.:.|..||..|.
 Worm   242 DLADAKHKIVFLEERVSQLEN------------EAEKVNESKKAGNIEDIAALGSVLVQKDDVIQ 294

Human   312 RLLKDV-QHLQSSLQELEEASANQIADLERQLTAKSEAIEKLEEKLQAQSDYEEIKTELSILKAM 375
            :|..|: :|..|.::||.:... .::.:|::.......:.:|:.:|::::|||.||.||.:|:.:
 Worm   295 QLTNDIKRHEASHVEELAKWKL-AVSAVEKKNKTLIGELNELKNQLESRNDYEAIKNELRLLREI 358

Human   376 KLASSTCSLPQGMAK---------------------PEDSLLIAKEAFFPTQK-------FLLEK 412
            :...|..:..:.:.:                     ...||.:|.:.|....:       .|.||
 Worm   359 EFGDSAEANAESIERLGETVETLDRLLAEKNRRLQNENASLRVANDGFKGRNEEQEAELTVLKEK 423

Human   413 PS----LLASPEEDPS---EDDSIKDSLGTEQSYPSPQQLPPPPGPEDPLSPSPGQPLLGPSLGP 470
            ..    |:|..|.|.:   :|..|.:.:||.      :.|...|.|  .:|.:...|:|......
 Worm   424 SERNDRLIAQLEADLASAVQDIGIPERMGTN------EMLKDAPAP--TISDASLVPILTSQRNR 480

Human   471 DGTRTFSLSPFPSLASGERL 490
            ...|..||....||...::|
 Worm   481 LHERVTSLEEAISLEKTKQL 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CUX2NP_056082.2 PRK03918 <17..>269 CDD:235175 57/271 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..167 7/53 (13%)
Smc <179..>379 CDD:440809 47/224 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 415..481 17/68 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 517..549
CUT 553..625 CDD:460543
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 661..690
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 716..758
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..858
CUT 892..965 CDD:460543
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1032
CUT 1043..1119 CDD:460543
Homeodomain 1169..1225 CDD:459649
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1231..1453
cone-1NP_497577.2 SMC_prok_B <111..445 CDD:274008 67/349 (19%)
CASP_C 414..594 CDD:462392 23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.